Prevalence of Transmitted Antiretroviral Resistance and Distribution of HIV-1 Subtypes Among Patients with Recent Infection in Catalonia (Spain) between 2003 and 2005
Por:
Romero, A, Sued, O, Esteve, A, Pumarola, T, Casabona, J, Gonzalez, V, Matas, L, Tural, C, Rodrigo, I, Margall, N, Domingo, P, Casanova, A, Ferrer, E, Caballero, E, Ribera, E, Farre, J, Puig, T, Amengual, MJ, Navarro, G, Prat, JM, Masabeu, A, Simo, JM, Villaverde, CA, Barrufet, P, Sauca, MG, Ortin, X, Orti, A, Navarro, R, Euras, JM, Vilaro, J, Villa, MC, Montull, S, Vilanova, C, Pujol, F, Diaz, O, Miro, JM
Publicada:
1 ago 2011
Resumen:
Objectives: The objectives of this study were to assess the prevalence of transmitted HIV-1 drug resistances (TDR) and HIV-1 subtypes in recently infected patients in Catalonia between 2003 and 2005 and to describe the characteristics of these patients according to the presence or absence of TDR and HIV-1 subtype.
Methods: After application of the Serological Testing Algorithm for Recent HIV Seroconversion (STARHS), residual aliquots of serum samples from recently infected antiretroviral-naive individuals were genotyped. FASTA sequences were analyzed using the HIVDB Program. The World Health Organization 2009 List of Mutations for Surveillance of Transmitted HIV-1 Drug Resistant HIV Strains was used to estimate the prevalence of TDR.
Results: Of 182 recently infected patients, 14(7.7%) presented TDR. Seven (3.8%) had genotypic evidence of TDR against non-nucleoside reverse transcriptase inhibitors, 6(3.3%) against nucleoside reverse transcriptase inhibitors, 3 (1.6%) against protease inhibitors (Pis), and only 2 individuals (1.1%) presented TDR against more than one class of drugs. Thirty-five (19.2%) patients were infected with a non-B HIV-1 subtype.
Conclusion: This is the first study to estimate the prevalence of TDR in recently infected patients in Catalonia. The results are similar to those of studies performed in other Spanish regions. Correct monitoring of these parameters requires systematic epidemiologic surveillance of transmitted resistance. (C) 2010 Elsevier Espana, S.L. All rights reserved.
Filiaciones:
Romero, A:
Ctr Epidemiol Studies HIV AIDS & STI Catalonia CE, Inst Catala & Oncol, Dept Hlth, Generalitat De Catalunya, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Univ Autonoma Barcelona, Dept Paediat Obstet & Gynaecol, E-08193 Barcelona, Spain
IMIM Parc Salut Mar, Dept Epidemiol & Evaluat, Barcelona, Spain
Sued, O:
Univ Barcelona, Hosp Clin, IDIBAPS, Barcelona, Spain
Esteve, A:
Ctr Epidemiol Studies HIV AIDS & STI Catalonia CE, Inst Catala & Oncol, Dept Hlth, Generalitat De Catalunya, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Pumarola, T:
Univ Barcelona, Hosp Clin, IDIBAPS, Barcelona, Spain
Casabona, J:
Ctr Epidemiol Studies HIV AIDS & STI Catalonia CE, Inst Catala & Oncol, Dept Hlth, Generalitat De Catalunya, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Univ Autonoma Barcelona, Dept Paediat Obstet & Gynaecol, E-08193 Barcelona, Spain
IMIM Parc Salut Mar, Dept Epidemiol & Evaluat, Barcelona, Spain
Gonzalez, V:
Ctr Epidemiol Studies HIV AIDS & STI Catalonia CE, Inst Catala & Oncol, Dept Hlth, Generalitat De Catalunya, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Dept Genet & Microbiol, Microbiol Serv, Badalona, Spain
Matas, L:
Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Dept Genet & Microbiol, Microbiol Serv, Badalona, Spain
Rodrigo, I:
Lab Clin Manso, Barcelona, Spain
Margall, N:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Domingo, P:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Casanova, A:
Hosp Univ Bellvitge, IDIBELL, Lhospitalet De Llobregat, Spain
Ferrer, E:
Hosp Univ Bellvitge, IDIBELL, Lhospitalet De Llobregat, Spain
Caballero, E:
Univ Autonoma Barcelona, Hosp Univ Vall dHebron, E-08193 Barcelona, Spain
Ribera, E:
Univ Autonoma Barcelona, Hosp Univ Vall dHebron, E-08193 Barcelona, Spain
Farre, J:
Hosp Arnau Vilanova, Lleida, Spain
Puig, T:
Inst Recerca SIDA irsiCaixa, Badalona, Spain
Hosp Arnau Vilanova, Lleida, Spain
Amengual, MJ:
Univ Autonoma Barcelona, Univ Parc Tauli, Sabadell, Spain
Univ Autonoma Barcelona, Corp Sanitaria, Sabadell, Spain
Navarro, G:
Univ Autonoma Barcelona, Univ Parc Tauli, Sabadell, Spain
Univ Autonoma Barcelona, Corp Sanitaria, Sabadell, Spain
Prat, JM:
Hosp Palamos, Palamos, Spain
Masabeu, A:
Hosp Palamos, Palamos, Spain
Simo, JM:
Hosp Univ St Joan Reus, Reus, Spain
Villaverde, CA:
Hosp Univ St Joan Reus, Reus, Spain
Barrufet, P:
Hosp Mataro, Mataro, Spain
Sauca, MG:
Hosp Mataro, Mataro, Spain
Ortin, X:
Hosp Tortosa Verge Cinta, Tortosa, Spain
Orti, A:
Hosp Tortosa Verge Cinta, Tortosa, Spain
Euras, JM:
Hosp Gen Vic, Vic, Spain
Vilaro, J:
Hosp Gen Vic, Vic, Spain
Villa, MC:
Hosp Gen Granollers, Granollers, Spain
Montull, S:
Hosp Gen Granollers, Granollers, Spain
Pujol, F:
Projecte Dels Noms Hispanosida, Barcelona, Spain
Diaz, O:
SAPS Creu Raja, Barcelona, Spain
Miro, JM:
Univ Barcelona, Hosp Clin, IDIBAPS, Barcelona, Spain
Lab Clin Cornella de Llobregat, Cornella De Llobregat, Spain.
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