MDS Task Force on Mild Cognitive Impairment in Parkinson's Disease: Critical Review of PD-MCI
Por:
Litvan, I, Aarsland, D, Adler, CH, Goldman, JG, Kulisevsky, J, Mollenhauer, B, Rodriguez-Oroz, MC, Troster, AI, Weintraub, D
Publicada:
15 ago 2011
Resumen:
There is controversy regarding the definition and characteristics of mild cognitive impairment in Parkinson's disease. The Movement Disorder Society commissioned a Task Force to critically evaluate the literature and determine the frequency and characteristics of Parkinson's disease-mild cognitive impairment and its association with dementia. A comprehensive PubMed literature review was conducted using systematic inclusion and exclusion criteria. A mean of 26.7% (range, 18.9%-38.2%) of nondemented patients with Parkinson's disease have mild cognitive impairment. The frequency of Parkinson's disease-mild cognitive impairment increases with age, disease duration, and disease severity. Impairments occur in a range of cognitive domains, but single domain impairment is more common than multiple domain impairment, and within single domain impairment, nonamnestic is more common than amnestic impairment. A high proportion of patients with Parkinson's disease-mild cognitive impairment progress to dementia in a relatively short period of time. The primary conclusions of the Task Force are that: (1) Parkinson's disease-mild cognitive impairment is common, (2) there is significant heterogeneity within Parkinson's disease-mild cognitive impairment in the number and types of cognitive domain impairments, (3) Parkinson's disease-mild cognitive impairment appears to place patients at risk of progressing to dementia, and (4) formal diagnostic criteria for Parkinson's disease-mild cognitive impairment are needed. (C)2011 Movement Disorder Society
Filiaciones:
Litvan, I:
Univ Louisville, Sch Med, Dept Neurol, Div Movement Disorders, Louisville, KY 40241 USA
Frazier Rehab Neurosci Inst, Movement Disorders Program, Louisville, KY USA
Aarsland, D:
Stavanger Univ Hosp, Ctr Age Related Med, Oslo, Norway
Univ Oslo, Akershus Univ Hosp, Oslo, Norway
Adler, CH:
Mayo Clin, Dept Neurol, Parkinsons Dis & Movement Disorders Ctr, Scottsdale, AZ USA
Goldman, JG:
Rush Univ, Med Ctr, Sect Parkinson Dis & Movement Disorders, Dept Neurol Sci, Chicago, IL 60612 USA
Kulisevsky, J:
St Pau Hosp, Dept Neurol, Movement Disorders Unit, Madrid, Spain
Univ Autonoma Barcelona, Inst Biomed Res IIB St Pau, Madrid, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Mollenhauer, B:
Univ Gottingen, Paracelsus Elena Klin, Gottingen, Germany
Rodriguez-Oroz, MC:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Univ Navarra Clin, Dept Neurol, Sch Med, Ctr Neurosci,CIMA, Pamplona, Spain
Troster, AI:
Univ N Carolina, Sch Med, Dept Neurol, Chapel Hill, NC 27599 USA
Weintraub, D:
Univ Penn, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA
Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA
Philadelphia Vet Affairs Med Ctr, PADRECC, Philadelphia, PA USA
Philadelphia Vet Affairs Med Ctr, MIRECC, Philadelphia, PA USA
Green Accepted
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