Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers
Por:
Antoniou, AC, Kartsonaki, C, Sinilnikova, OM, Soucy, P, McGuffog, L, Healey, S, Lee, A, Peterlongo, P, Manoukian, S, Peissel, B, Zaffaroni, D, Cattaneo, E, Barile, M, Pensotti, V, Pasini, B, Dolcetti, R, Giannini, G, Putignano, AL, Varesco, L, Radice, P, Mai, PL, Greene, MH, Andrulis, IL, Glendon, G, Ozcelik, H, Thomassen, M, Gerdes, AM, Kruse, TA, Jensen, UB, Cruger, DG, Caligo, MA, Laitman, Y, Milgrom, R, Kaufman, B, Paluch-Shimon, S, Friedman, E, Loman, N, Harbst, K, Lindblom, A, Arver, B, Ehrencrona, H, Melin, B, Nathanson, KL, Domchek, SM, Rebbeck, T, Jakubowska, A, Lubinski, J, Gronwald, J, Huzarski, T, Byrski, T, Cybulski, C, Gorski, B, Osorio, A, Cajal, TRY, Fostira, F, Andres, R, Benitez, J, Hamann, U, Hogervorst, FB, Rookus, MA, Hooning, MJ, Nelen, MR, van der Luijt, RB, van Os, TAM, van Asperen, CJ, Devilee, P, Meijers-Heijboer, HEJ, Garcia, EBG, Peock, S, Cook, M, Frost, D, Platte, R, Leyland, J, Evans, DG, Lalloo, F, Eeles, R, Izatt, L, Adlard, J, Davidson, R, Eccles, D, Ong, KR, Cook, J, Douglas, F, Paterson, J, Kennedy, MJ, Miedzybrodzka, Z, Godwin, A, Stoppa-Lyonnet, D, Buecher, B, Belotti, M, Tirapo, C, Mazoyer, S, Barjhoux, L, Lasset, C, Leroux, D, Faivre, L, Bronner, M, Prieur, F, Nogues, C, Rouleau, E, Pujol, P, Coupier, I, Frenay, M, Hopper, JL, Daly, MB, Terry, MB, John, EM, Buys, SS, Yassin, Y, Miron, A, Goldgar, D, Singer, CF, Tea, MK, Pfeiler, G, Dressler, AC, Hansen, TV, Jonson, L, Ejlertsen, B, Barkardottir, RB, Kirchhoff, T, Offit, K, Piedmonte, M, Rodriguez, G, Small, L, Boggess, J, Blank, S, Basil, J, Azodi, M, Toland, AE, Montagna, M, Tognazzo, S, Agata, S, Imyanitov, E, Janavicius, R, Lazaro, C, Blanco, I, Pharoah, PDP, Sucheston, L, Karlan, BY, Walsh, CS, Olah, E, Bozsik, A, Teo, SH, Seldon, JL, Beattie, MS, van Rensburg, EJ, Sluiter, MD, Diez, O, Schmutzler, RK, Wappenschmidt, B, Engel, C, Meindl, A, Ruehl, I, Varon-Mateeva, R, Kast, K, Deissler, H, Niederacher, D, Arnold, N, Gadzicki, D, Schonbuchner, I, Caldes, T, de la Hoya, M, Nevanlinna, H, Aittomaki, K, Dumont, M, Chiquette, J, Tischkowitz, M, Chen, XQ, Beesley, J, Spurdle, AB, Neuhausen, SL, Ding, YC, Fredericksen, Z, Wang, X, Pankratz, VS, Couch, F, Simard, J, Easton, DF, Chenevix-Trench, G
Publicada:
15 ago 2011
Resumen:
Two single nucleotide polymorphisms (SNPs) at 6q25.1, near the ESR1 gene, have been implicated in the susceptibility to breast cancer for Asian (rs2046210) and European women (rs9397435). A genome-wide association study in Europeans identified two further breast cancer susceptibility variants: rs11249433 at 1p11.2 and rs999737 in RAD51L1 at 14q24.1. Although previously identified breast cancer susceptibility variants have been shown to be associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers, the involvement of these SNPs to breast cancer susceptibility in mutation carriers is currently unknown. To address this, we genotyped these SNPs in BRCA1 and BRCA2 mutation carriers from 42 studies from the Consortium of Investigators of Modifiers of BRCA1/2. In the analysis of 14 123 BRCA1 and 8053 BRCA2 mutation carriers of European ancestry, the 6q25.1 SNPs (r(2) = 0.14) were independently associated with the risk of breast cancer for BRCA1 mutation carriers [ hazard ratio (HR) = 1.17, 95% confidence interval (CI): 1.11-1.23, P-trend = 4.5 x 10(-9) for rs2046210; HR = 1.28, 95% CI: 1.18-1.40, P-trend = 1.3 x 10(-8) for rs9397435], but only rs9397435 was associated with the risk for BRCA2 carriers (HR = 1.14, 95% CI: 1.01-1.28, P-trend = 0.031). SNP rs11249433 (1p11.2) was associated with the risk of breast cancer for BRCA2 mutation carriers (HR = 1.09, 95% CI: 1.02-1.17, P-trend = 0.015), but was not associated with breast cancer risk for BRCA1 mutation carriers (HR = 0.97, 95% CI: 0.92-1.02, P-trend = 0.20). SNP rs999737 (RAD51L1) was not associated with breast cancer risk for either BRCA1 or BRCA2 mutation carriers (P-trend = 0.27 and 0.30, respectively). The identification of SNPs at 6q25.1 associated with breast cancer risk for BRCA1 mutation carriers will lead to a better understanding of the biology of tumour development in these women.
Filiaciones:
Antoniou, AC:
Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge CB1 8RN, England
Sinilnikova, OM:
Ctr Hosp Univ Lyon, Ctr Leon Berard, Unite Mixte Genet Constitut Canc Frequents, Lyon, France
Univ Lyon, Ctr Leon Berard, CNRS, Equipe Labellisee LIGUE 2008,UMR5201, Lyon, France
Healey, S:
Queensland Inst Med Res, Brisbane, Qld 4006, Australia
Peterlongo, P:
Fdn IRCCS Ist Nazl Tumori INT, Dept Prevent & Predict Med, Unit Mol Bases Genet Risk & Genet Testing, Milan, Italy
Fdn Ist FIRC Oncol Mol, IFOM, Milan, Italy
Manoukian, S:
Fdn IRCCS Ist Nazl Tumori INT, Dept Prevent & Predicted Med, Unit Med Genet, Milan, Italy
Peissel, B:
Fdn IRCCS Ist Nazl Tumori INT, Dept Prevent & Predicted Med, Unit Med Genet, Milan, Italy
Zaffaroni, D:
Fdn IRCCS Ist Nazl Tumori INT, Dept Prevent & Predicted Med, Unit Med Genet, Milan, Italy
Cattaneo, E:
Fdn IRCCS Ist Nazl Tumori INT, Dept Prevent & Predicted Med, Unit Med Genet, Milan, Italy
Barile, M:
IEO, Div Canc Prevent & Genet, Milan, Italy
Pensotti, V:
Cogentech, Consortium Genom Technol, Milan, Italy
Pasini, B:
Univ Turin, Dept Genet Biol & Biochem, Turin, Italy
Dolcetti, R:
IRCCS, Ctr Riferimento Oncol, Canc Bioimmunotherapy Unit, Aviano, PN, Italy
Giannini, G:
Univ Roma La Sapienza, Dept Expt Med, Rome, Italy
Putignano, AL:
Univ Florence, Dept Clin Physiopathol, Florence, Italy
Fiorgen Fdn Pharmacogen, Sesto Fiorentino, Italy
Varesco, L:
Ist Nazl Ric Canc IST, Dept Epidemiol Prevent & Special Funct, Unit Hereditary Canc, Genoa, Italy
Radice, P:
Fdn IRCCS Ist Nazl Tumori INT, Dept Prevent & Predict Med, Unit Mol Bases Genet Risk & Genet Testing, Milan, Italy
Mai, PL:
US Natl Canc Inst, Clin Genet Branch, Div Canc Epidemiol & Genet, Rockville, MD USA
Greene, MH:
US Natl Canc Inst, Clin Genet Branch, Div Canc Epidemiol & Genet, Rockville, MD USA
Andrulis, IL:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Univ Toronto, Dept Mol Genet, Toronto, ON, Canada
Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
Canc Care Ontario, Toronto, ON, Canada
Glendon, G:
Canc Care Ontario, Toronto, ON, Canada
Ozcelik, H:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
Thomassen, M:
Odense Univ Hosp, DK-5000 Odense C, Denmark
Gerdes, AM:
Rigshosp, DK-2100 Copenhagen, Denmark
Kruse, TA:
Odense Univ Hosp, DK-5000 Odense C, Denmark
Jensen, UB:
Aarhus Univ Hosp, DK-8000 Aarhus, Denmark
Cruger, DG:
Vejle Hosp, Vejle, Denmark
Caligo, MA:
Univ Pisa, Dept Lab Med, Sect Genet Oncol, Pisa, Italy
Univ Hosp Pisa, Pisa, Italy
Laitman, Y:
Sheba Med Ctr, Susanne Levy Gertner Oncogenet Unit, Tel Hashomer, Israel
Milgrom, R:
Sheba Med Ctr, Susanne Levy Gertner Oncogenet Unit, Tel Hashomer, Israel
Kaufman, B:
Sheba Med Ctr, Inst Oncol, Breast Canc Unit, Tel Hashomer, Israel
Paluch-Shimon, S:
Sheba Med Ctr, Inst Oncol, Breast Canc Unit, Tel Hashomer, Israel
Friedman, E:
Sheba Med Ctr, Susanne Levy Gertner Oncogenet Unit, Tel Hashomer, Israel
Loman, N:
Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden
Harbst, K:
Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden
Lindblom, A:
Karolinska Univ Hosp, Dept Clin Genet, S-17176 Stockholm, Sweden
Arver, B:
Karolinska Univ Hosp, Dept Oncol, S-17176 Stockholm, Sweden
Ehrencrona, H:
Uppsala Univ, Rudbeck Lab, Dept Genet & Pathol, S-75185 Uppsala, Sweden
Melin, B:
Umea Univ, Dept Radiat Sci, S-90185 Umea, Sweden
Nathanson, KL:
Univ Penn, Philadelphia, PA 19104 USA
Domchek, SM:
Univ Penn, Philadelphia, PA 19104 USA
Rebbeck, T:
Univ Penn, Philadelphia, PA 19104 USA
Jakubowska, A:
Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland
Lubinski, J:
Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland
Gronwald, J:
Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland
Huzarski, T:
Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland
Byrski, T:
Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland
Cybulski, C:
Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland
Gorski, B:
Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland
Osorio, A:
Spanish Natl Canc Res Ctr, Human Canc Genet Programme, Human Genet Grp, Madrid, Spain
Cajal, TRY:
Hosp Santa Creu & Sant Pau, Oncol Serv, Barcelona, Spain
Fostira, F:
Natl Ctr Sci Res Demokritos, IRRP, Mol Diagnost Lab, Athens, Greece
Andres, R:
Hosp Clin Univ Lozano Blesa, Oncol unit, Zaragoza, Spain
Benitez, J:
Spanish Natl Canc Res Ctr, Human Canc Genet Programme, Human Genet Grp, Madrid, Spain
Hamann, U:
Deutsch Krebsforschungszentrum, D-6900 Heidelberg, Germany
Hogervorst, FB:
Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands
Rookus, MA:
Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands
Hooning, MJ:
Erasmus Univ, Med Ctr, Family Canc Clin, Dept Med Oncol, Rotterdam, Netherlands
Nelen, MR:
Radboud Univ Nijmegen, Med Ctr, Dept Human Genet 849, NL-6525 ED Nijmegen, Netherlands
van der Luijt, RB:
Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands
van Os, TAM:
Univ Amsterdam, Acad Med Ctr, Dept Clin Genet, NL-1105 AZ Amsterdam, Netherlands
van Asperen, CJ:
Leiden Univ, Med Ctr Leiden, Dept Clin Genet, Leiden, Netherlands
Devilee, P:
Leiden Univ, Med Ctr Leiden, Dept Human Genet, Leiden, Netherlands
Leiden Univ, Med Ctr Leiden, Dept Pathol, Leiden, Netherlands
Meijers-Heijboer, HEJ:
Vrije Univ Amsterdam Med Ctr, Dept Clin Genet, Amsterdam, Netherlands
Garcia, EBG:
MUMC, Sch Oncol, Dept Clin Genet, Maastricht, Netherlands
MUMC, Sch Oncol, GROM, Maastricht, Netherlands
Evans, DG:
Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England
Lalloo, F:
Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England
Eeles, R:
Inst Canc Res, Oncogenet Team, Surrey, England
Royal Marsden NHS Fdn Trust, Surrey, England
Izatt, L:
Guys & St Thomas NHS Fdn Trust, London, England
Adlard, J:
Yorkshire Reg Genet Serv, Leeds, W Yorkshire, England
Davidson, R:
Yorkhill Hosp, Ferguson Smith Ctr Clin Genet, Glasgow, Lanark, Scotland
Eccles, D:
Princess Anne Hosp, Wessex Clin Genet Serv, Southampton, Hants, England
Ong, KR:
Birmingham Womens Hosp Healthcare NHS Trust, W Midlands Reg Genet Serv, Birmingham, W Midlands, England
Cook, J:
Sheffield Childrens Hosp, Sheffield Clin Genet Serv, Sheffield, S Yorkshire, England
Douglas, F:
Newcastle Tyne Hosp NHS Trust, Ctr Life, Inst Human Genet, Newcastle Upon Tyne, Tyne & Wear, England
Paterson, J:
Addenbrookes Hosp, E Anglian Reg Genet Serv, Dept Clin Genet, Cambridge, England
Kennedy, MJ:
Trinity Coll Dublin, Acad Unit Clin & Mol Oncol, Dublin, Ireland
St James Hosp, Dublin, Ireland
Miedzybrodzka, Z:
NHS Grampian & Univ Aberdeen, N Scotland Reg Genet Serv, Aberdeen, Scotland
Godwin, A:
Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66103 USA
Stoppa-Lyonnet, D:
Inst Curie, Serv Genet Oncol, Paris, France
Inst Curie, INSERM, Unite U830, Paris, France
Univ Paris 05, Fac Med, Paris, France
Buecher, B:
Inst Curie, Serv Genet Oncol, Paris, France
Belotti, M:
Inst Curie, Serv Genet Oncol, Paris, France
Tirapo, C:
Inst Curie, Serv Genet Oncol, Paris, France
Mazoyer, S:
Univ Lyon, Ctr Leon Berard, CNRS, Equipe Labellisee LIGUE 2008,UMR5201, Lyon, France
Barjhoux, L:
Univ Lyon, Ctr Leon Berard, CNRS, Equipe Labellisee LIGUE 2008,UMR5201, Lyon, France
Lasset, C:
Univ Lyon 1, CNRS, UMR5558, F-69365 Lyon, France
Ctr Leon Berard, Unite Prevent & Epidemiol Genet, F-69373 Lyon, France
Leroux, D:
CHU Grenoble, Dept Genet, F-38043 Grenoble, France
Univ Grenoble, Inst Albert Bonniot, Grenoble, France
Faivre, L:
CHU Dijon, Ctr Genet, Dijon, France
Ctr Lutte Canc Georges Francois Leclerc, Dijon, France
Bronner, M:
Nancy Univ, Ctr Hosp Reg & Univ, Med Genet Lab, Vandoeuvre Les Nancy, France
Prieur, F:
Ctr Antoine Lacassagne, F-06054 Nice, France
Nogues, C:
Hop Rene Huguenin, Inst Curie, Oncogenet Clin, St Cloud, France
Rouleau, E:
Hop Rene Huguenin, Inst Curie, Lab Oncogenet, St Cloud, France
Pujol, P:
CHU Arnaud de Villeneuve, Unite Oncogenet, Montpellier, France
CRCM Val dAurelle, INSERM 896, Montpellier, France
Coupier, I:
CHU Arnaud de Villeneuve, Unite Oncogenet, Montpellier, France
CRLCC Val dAurelle, Unite Oncogenet, Montpellier, France
Frenay, M:
Ctr Antoine Lacassagne, F-06054 Nice, France
Hopper, JL:
Univ Melbourne, Melbourne, Vic, Australia
Daly, MB:
Fox Chase Canc Ctr, Dept Med Oncol, Womens Canc Program, Philadelphia, PA 19111 USA
Terry, MB:
Columbia Univ, New York, NY USA
John, EM:
Canc Prevent Inst Calif, Fremont, CA USA
Stanford Univ, Sch Med, Stanford Canc Ctr, Stanford, CA 94305 USA
Buys, SS:
Univ Utah, Hlth Sci Ctr, Huntsman Canc Inst, Salt Lake City, UT USA
Yassin, Y:
Dana Farber Canc Inst, Boston, MA 02115 USA
Miron, A:
Dana Farber Canc Inst, Boston, MA 02115 USA
Goldgar, D:
Univ Utah, Dept Dermatol, Salt Lake City, UT USA
Singer, CF:
Med Univ Vienna, Dept Obstet Gynecol, Vienna, Austria
Tea, MK:
Med Univ Vienna, Dept Obstet Gynecol, Vienna, Austria
Pfeiler, G:
Med Univ Vienna, Dept Obstet Gynecol, Vienna, Austria
Dressler, AC:
Med Univ Vienna, Dept Obstet Gynecol, Vienna, Austria
Hansen, TV:
Copenhagen Univ Hosp, Rigshosp, Dept Clin Biochem, Allerod, Denmark
Jonson, L:
Copenhagen Univ Hosp, Rigshosp, Dept Clin Biochem, Allerod, Denmark
Ejlertsen, B:
Copenhagen Univ Hosp, Rigshosp, Dept Oncol, Allerod, Denmark
Barkardottir, RB:
Landspitali Univ Hosp, Dept Pathol, Cell Biol Lab, Tromso, Norway
Univ Iceland, Fac Med, Reykjavik, Iceland
Kirchhoff, T:
Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, New York, NY 10021 USA
Offit, K:
Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, New York, NY 10021 USA
Piedmonte, M:
Roswell Pk Canc Inst, GOG Stat & Data Ctr, Buffalo, NY 14263 USA
Rodriguez, G:
Evanston NW Healthcare, Evanston, IL USA
Small, L:
Maine Med Ctr, Scarborough, ME USA
Boggess, J:
Univ N Carolina, Chapel Hill, NC USA
Blank, S:
NYU, Sch Med, New York, NY USA
Basil, J:
St Elizabeth Hosp, Edgewood, KY USA
Azodi, M:
Yale Univ, Sch Med, New Haven, CT USA
Toland, AE:
Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA
Montagna, M:
Ist Oncol Veneto IOV IRCCS, Immunol & Mol Oncol Unit, Padua, Italy
Tognazzo, S:
Ist Oncol Veneto IOV IRCCS, Immunol & Mol Oncol Unit, Padua, Italy
Agata, S:
Ist Oncol Veneto IOV IRCCS, Immunol & Mol Oncol Unit, Padua, Italy
Imyanitov, E:
NN Petrov Inst Oncol, St Petersburg 197758, Russia
Janavicius, R:
Vilnius Univ Hosp Santariskiu Clin, Hematol Oncol & Transfus Med Ctr, Dept Mol & Regenerat Med, Vilnius, Lithuania
State Res Inst Inovat Med Ctr, Vilnius, Lithuania
Lazaro, C:
Catalan Inst Oncol, Hereditary Canc Program, Barcelona, Spain
Blanco, I:
Catalan Inst Oncol, Hereditary Canc Program, Barcelona, Spain
Pharoah, PDP:
Univ Cambridge, Dept Oncol, Cambridge CB1 8RN, England
Sucheston, L:
Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA
Karlan, BY:
Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Res Inst, Los Angeles, CA 90048 USA
Walsh, CS:
Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Res Inst, Los Angeles, CA 90048 USA
Olah, E:
Natl Inst Oncol, Dept Mol Genet, Budapest, Hungary
Bozsik, A:
Natl Inst Oncol, Dept Mol Genet, Budapest, Hungary
Teo, SH:
Sime Darby Med Ctr, Canc Res Initiat Fdn, Subang Jaya, Malaysia
Univ Malaya, Canc Res Inst, Kuala Lumpur, Malaysia
Seldon, JL:
Univ Calif Los Angeles, Canc Genet Program, CLA Jonsson Comp Canc Ctr, Santa Monica, CA USA
Beattie, MS:
Univ Calif San Francisco, UCSF Canc Risk Program, San Francisco, CA 94143 USA
Univ Calif San Francisco, UCSF Dept Med, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Biostat, San Francisco, CA 94143 USA
van Rensburg, EJ:
Univ Pretoria, Dept Genet, ZA-0002 Pretoria, South Africa
Sluiter, MD:
Univ Pretoria, Dept Genet, ZA-0002 Pretoria, South Africa
Diez, O:
Univ Hosp Vall dHebron, Oncogenet Lab, Barcelona, Spain
VHIO, Barcelona, Spain
Schmutzler, RK:
Univ Hosp Cologne, Dept Obstet & Gynaecol, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Univ Hosp Cologne, CIO, Cologne, Germany
Wappenschmidt, B:
Univ Hosp Cologne, Dept Obstet & Gynaecol, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Univ Hosp Cologne, CIO, Cologne, Germany
Engel, C:
Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany
Meindl, A:
Tech Univ Munich, Klinikum Rechts Isar, Div Tumor Genet, Dept Obstet & Gynaecol, D-8000 Munich, Germany
Ruehl, I:
Univ Munich, Dept Obstet & Gynaecol, Munich, Germany
Varon-Mateeva, R:
Campus Virchov Klinikum, Inst Human Genet, Charite, Berlin, Germany
Kast, K:
Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Obstet & Gynaecol, Dresden, Germany
Deissler, H:
Univ Hosp Ulm, Dept Obstet & Gynaecol, Ulm, Germany
Niederacher, D:
Univ Dusseldorf, Univ Hosp Dusseldorf, Dept Obstet & Gynaecol, Dusseldorf, Germany
Arnold, N:
Univ Kiel, Dept Obstet & Gynaecol, Univ Hosp Schleswigholstein, Kiel, Germany
Gadzicki, D:
Hannover Med Sch, Inst Cell & Mol Pathol, D-3000 Hannover, Germany
Schonbuchner, I:
Univ Wurzburg, Inst Human Genet, Dept Med Genet, Ctr Familial Breast & Ovarian Canc, D-8700 Wurzburg, Germany
Caldes, T:
Hosp Clin San Carlos, Mol Oncol Lab, Madrid, Spain
de la Hoya, M:
Hosp Clin San Carlos, Mol Oncol Lab, Madrid, Spain
Nevanlinna, H:
Univ Helsinki, Cent Hosp, Dept Obstet & Gynecol, FIN-00290 Helsinki, Finland
Aittomaki, K:
Univ Helsinki, Cent Hosp, Dept Clin Genet, Helsinki, Finland
Chiquette, J:
Univ Quebec, Ctr Hosp, Ctr Rech FRSQ, Unite Rech Sante Populat,Ctr Malad Sein Deschenes, Quebec City, PQ, Canada
Tischkowitz, M:
McGill Univ, Dept Human Genet, Program Canc Genet, Montreal, PQ, Canada
McGill Univ, Dept Oncol, Montreal, PQ, Canada
McGill Univ, Jewish Gen Hosp, Segal Canc Ctr, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada
Chen, XQ:
Queensland Inst Med Res, Brisbane, Qld 4006, Australia
Beesley, J:
Queensland Inst Med Res, Brisbane, Qld 4006, Australia
Spurdle, AB:
Queensland Inst Med Res, Brisbane, Qld 4006, Australia
Neuhausen, SL:
Beckman Res Inst City Hope, Dept Populat Sci, Duarte, CA USA
Ding, YC:
Beckman Res Inst City Hope, Dept Populat Sci, Duarte, CA USA
Fredericksen, Z:
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Wang, X:
Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
Pankratz, VS:
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Couch, F:
Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
Simard, J:
Ctr Hosp Univ Quebec, Canc Genom Lab, Canada Res Chair Oncogenet, Quebec City, PQ, Canada
Chenevix-Trench, G:
Queensland Inst Med Res, Brisbane, Qld 4006, Australia
Univ Laval, Quebec City, PQ, Canada.
Univ Milan, Dept Med Surg & Dent, Milan, Italy.
Ctr Hosp Univ St Etienne, Serv Genet Clin Chromos & Mol, St Etienne, France.
Bronze, Green Published
|