The European Registry on Cushing's syndrome: 2-year experience. Baseline demographic and clinical characteristics
Por:
Valassi, E, Santos, A, Yaneva, M, Toth, M, Strasburger, CJ, Chanson, P, Wass, JAH, Chabre, O, Pfeifer, M, Feelders, RA, Tsagarakis, S, Trainer, PJ, Franz, H, Zopf, K, Zacharieva, S, Lamberts, SWJ, Tabarin, A, Webb, SM, ERCUSYN Study Grp
Publicada:
1 sep 2011
Resumen:
Objective: The European Registry on Cushing's syndrome (ERCUSYN) is designed to collect prospective and follow-up data at EU level on Cushing's syndrome (CS).
Design and methods: Baseline data on 481 CS patients (390 females, 91 males; mean age (+/- S.D.): 44 +/- 14 years) collected from 36 centres in 23 countries, including new patients from 2008 and retrospective cases since 2000. Patients were divided into four major aetiologic groups: pituitary-dependent CS (PIT-CS) (66%), adrenal-dependent CS (ADR-CS) (27%), CS from an ectopic source (ECT-CS) (5%) and CS from other aetiologies (2%).
Results: Proportion of men in the ECT-CS group was higher than in the other groups (P < 0.05). The ADR-CS group was older than the PIT-CS (P < 0.05). Prevalence of hirsutism (92%) and diabetes (74%) in ECT-CS was higher than in the other groups (P < 0.05 and P < 0.01 respectively). PIT-CS had more skin alterations, menstrual irregularities and hirsutism than ADR-CS (P < 0.01). Reduced libido was more prevalent in men than women (P < 0.01). Prevalence of spine osteoporosis was higher in men than women (P < 0.05), and males had more vertebral and rib fractures than females (52 vs 18% for vertebrae; P < 0.001 and 34 vs 23% for ribs; P < 0.05). ECT-CS consulted a diabetologist more frequently than ADR-CS (P < 0.05), while a gynaecologist was consulted more often by women with PIT-CS or ADR-CS than with ECT-CS (P < 0.05). Overall, weight gain was more common in women than men (P < 0.01). CushingQoL and EuroQoL visual analogue scale scores did not differ between the groups.
Conclusions: The ERCUSYN project demonstrates a heterogeneous clinical presentation of CS at a European level, depending on gender and aetiology.
Filiaciones:
Valassi, E:
UAB, IIB St Pau, Hosp St Pau, Barcelona 08025, Spain
UAB, Dept Endocrinol Med, Hosp St Pau, Barcelona 08025, Spain
ISCIII, Ctr Invest Biomed Red Enfermedades Raras CIBER ER, Unidad 747, Barcelona 08025, Spain
Santos, A:
UAB, IIB St Pau, Hosp St Pau, Barcelona 08025, Spain
UAB, Dept Endocrinol Med, Hosp St Pau, Barcelona 08025, Spain
ISCIII, Ctr Invest Biomed Red Enfermedades Raras CIBER ER, Unidad 747, Barcelona 08025, Spain
Yaneva, M:
Med Univ Sofia, Dept Pituitary & Adrenal Dis, Sofia, Bulgaria
Toth, M:
Semmelweis Univ, Dept Internal Med 2, Budapest, Hungary
Strasburger, CJ:
Charite, Div Clin Endocrinol, Dept Med CCM, D-13353 Berlin, Germany
Chanson, P:
Univ Paris Sud, UMR S693, F-94276 Paris, France
Hop Bicetre, AP HP, Serv Endocrinol & Malad Reprod, F-94275 Paris, France
INSERM, U693, F-94276 Paris, France
Wass, JAH:
Churchill Hosp, Dept Endocrinol, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LJ, England
Chabre, O:
Serv Endocrinol Diabetol Nutr, Grenoble, France
Pfeifer, M:
Univ Med Ctr, Dept Endocrinol, Ljubljana, Slovenia
Feelders, RA:
Erasmus MC, Dept Internal Med, Rotterdam, Netherlands
Tsagarakis, S:
Athens Polyclin Gen Hosp, Athens, Greece
Evangelisnos Hosp, Athens, Greece
Trainer, PJ:
Christie Hosp, Dept Endocrinol, Manchester M20 4BX, Lancs, England
Franz, H:
Lohmann & Birkner Hlth Care Consulting GmbH, Berlin, Germany
Zopf, K:
Charite, Div Clin Endocrinol, Dept Med CCM, D-13353 Berlin, Germany
Zacharieva, S:
Med Univ Sofia, Dept Pituitary & Adrenal Dis, Sofia, Bulgaria
Lamberts, SWJ:
Erasmus MC, Dept Internal Med, Rotterdam, Netherlands
Tabarin, A:
Ctr Hosp Univ Bordeaux, Bordeaux, France
Webb, SM:
UAB, IIB St Pau, Hosp St Pau, Barcelona 08025, Spain
UAB, Dept Endocrinol Med, Hosp St Pau, Barcelona 08025, Spain
ISCIII, Ctr Invest Biomed Red Enfermedades Raras CIBER ER, Unidad 747, Barcelona 08025, Spain
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