Neural correlates of cognitive impairment in schizophrenia
Por:
Ortiz-Gil, J, Pomarol-Clotet, E, Salvador, R, Canales-Rodriguez, EJ, Sarro, S, Gomar, JJ, Guerrero, A, Sans-Sansa, B, Capdevila, A, Junque, C, McKenna, PJ
Publicada:
1 sep 2011
Resumen:
Background
Cognitive impairment is an established feature of schizophrenia. However, little is known about its relationship to the structural and functional brain abnormalities that characterise the disorder.
Aims
To identify structural and/or functional brain abnormalities associated with schizophrenic cognitive impairment.
Method
We carried out structural magnetic resonance imaging (MRI) and voxel-based morphometry in 26 participants who were cognitively impaired and 23 who were cognitively preserved, all with schizophrenia, plus 39 matched controls. Nineteen of those who were cognitively impaired and 18 of those who were cognitively preserved plus 34 controls also underwent functional MRI during performance of a working memory task.
Results
No differences were found between the participants who were cognitively intact and those who were cognitively impaired in lateral ventricular volume or whole brain volume. Voxel-based morphometry also failed to reveal clusters of significant difference in grey and white matter volume between these two groups. However, during performance of the n-back task, the participants who were cognitively impaired showed hypoactivation compared with those who were cognitively intact in the dorsolateral prefrontal cortex among other brain regions.
Conclusions
Cognitive impairment in schizophrenia is not a function of the structural brain abnormality that accompanies the disorder but has correlates in altered brain function.
Filiaciones:
Ortiz-Gil, J:
Germanes Hosp Sagrat Cor de Jesus, Benito Menni Complex Assistencial Salut Mental, Barcelona 08830, Spain
CIBERSAM, Barcelona, Spain
Univ Barcelona, Med PhD Program, Barcelona, Spain
Pomarol-Clotet, E:
CIBERSAM, Barcelona, Spain
Germanes Hosp, FIDMAG, Barcelona, Spain
Salvador, R:
Germanes Hosp Sagrat Cor de Jesus, Benito Menni Complex Assistencial Salut Mental, Barcelona 08830, Spain
CIBERSAM, Barcelona, Spain
Fundacio St Joan de Deu, Barcelona, Spain
Canales-Rodriguez, EJ:
Germanes Hosp Sagrat Cor de Jesus, Benito Menni Complex Assistencial Salut Mental, Barcelona 08830, Spain
CIBERSAM, Barcelona, Spain
Sarro, S:
CIBERSAM, Barcelona, Spain
Germanes Hosp, FIDMAG, Barcelona, Spain
Gomar, JJ:
Germanes Hosp Sagrat Cor de Jesus, Benito Menni Complex Assistencial Salut Mental, Barcelona 08830, Spain
CIBERSAM, Barcelona, Spain
Guerrero, A:
Germanes Hosp Sagrat Cor de Jesus, Benito Menni Complex Assistencial Salut Mental, Barcelona 08830, Spain
Sans-Sansa, B:
Germanes Hosp Sagrat Cor de Jesus, Benito Menni Complex Assistencial Salut Mental, Barcelona 08830, Spain
Capdevila, A:
Fundacio St Joan de Deu, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Junque, C:
Univ Barcelona, Med PhD Program, Barcelona, Spain
Univ Barcelona, Dept Psychiat & Clin Psychobiol, Barcelona, Spain
August Pi & Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain
McKenna, PJ:
Germanes Hosp Sagrat Cor de Jesus, Benito Menni Complex Assistencial Salut Mental, Barcelona 08830, Spain
CIBERSAM, Barcelona, Spain
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