Usefulness of peripapillary nerve fiber layer thickness assessed by optical coherence tomography as a biomarker for Alzheimer's disease
Por:
Sanchez, D, Castilla-Marti, M, Rodriguez-Gomez, O, Valero, S, Piferrer, A, Martinez, G, Martinez, J, Serra, J, Moreno-Grau, S, Hernandez-Olasagarre, B, De Rojas, I, Hernandez, I, Abdelnour, C, Rosende-Roca, M, Vargas, L, Mauleon, A, Santos-Santos, MA, Alegret, M, Ortega, G, Espinosa, A, Perez-Cordon, A, Sanabria, A, Ciudin, A, Simo, R, Hernandez, C, Villaoslada, P, Ruiz, A, Tarraga, L, Boada, M
Publicada:
5 nov 2018
Resumen:
The use of optical coherence tomography (OCT) has been suggested as a potential biomarker for Alzheimer's Disease based on previously reported thinning of the retinal nerve fiber layer (RNFL) in Alzheimer's disease's (AD) and Mild Cognitive Impairment (MCI). However, other studies have not shown such results. 930 individuals (414 cognitively healthy individuals, 192 probable amnestic MCI and 324 probable AD) attending a memory clinic were consecutively included and underwent spectral domain OCT (Maestro, Topcon) examinations to assess differences in peripapillary RNFL thickness, using a design of high ecological validity. Adjustment by age, education, sex and OCT image quality was performed. We found a non-significant decrease in mean RNFL thickness as follows: control group: 100,20 +/- 14,60 mu m, MCI group: 98,54 +/- 14,43 mu m and AD group: 96,61 +/- 15,27 mu m. The multivariate adjusted analysis revealed no significant differences in mean overall (p = 0.352), temporal (p = 0,119), nasal (p = 0,151), superior (p = 0,435) or inferior (p = 0,825) quadrants between AD, MCI and control groups. These results do not support the usefulness of peripapillary RNFL analysis as a marker of cognitive impairment or in discriminating between cognitive groups. The analysis of other OCT measurements in other retinal areas and layers as biomarkers for AD should be tested further.
Filiaciones:
Sanchez, D:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Castilla-Marti, M:
Clin Oftalmol Dr Castilla, Barcelona, Spain
Hosp Gen Cataluna, Valles Ophthalmol Res, Sant Cugat Del Valles, Spain
Rodriguez-Gomez, O:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Valero, S:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Univ Vall dHebron, CIBERSAM, Psychiat Dept, Barcelona, Spain
Piferrer, A:
Topcon Espana Clin Affairs, St Just Desvern, Spain
Martinez, G:
Univ Antofagasta, Fac Med & Dent, Antofagasta, Chile
Iberoamer Cochrane Ctr, Barcelona, Spain
Martinez, J:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Serra, J:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Moreno-Grau, S:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Hernandez-Olasagarre, B:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
De Rojas, I:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Hernandez, I:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Abdelnour, C:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Rosende-Roca, M:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Vargas, L:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Mauleon, A:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Santos-Santos, MA:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Alegret, M:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Ortega, G:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Espinosa, A:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Perez-Cordon, A:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Sanabria, A:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Ciudin, A:
Vall dHebron Res Inst, Diabet & Metab Res Unit, Barcelona, Spain
Vall dHebron Res Inst, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Barcelona, Spain
Simo, R:
Vall dHebron Res Inst, Diabet & Metab Res Unit, Barcelona, Spain
Vall dHebron Res Inst, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Barcelona, Spain
Hernandez, C:
Vall dHebron Res Inst, Diabet & Metab Res Unit, Barcelona, Spain
Vall dHebron Res Inst, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Barcelona, Spain
Villaoslada, P:
Inst Invest Biomed August Pi Sunyer IDIBAPS, Barcelona, Spain
Ruiz, A:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Tarraga, L:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Boada, M:
Alzheimer Res Ctr, Barcelona, Spain
Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
gold, Green Published
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