New Metrics to Assess Type 2 Diabetes after Bariatric Surgery: The "Time-Within-Remission Range"


Por: de Hollanda, A, Lecube, A, Rubio, MA, Sanchez, E, Vilarrasa, N, Oliva, JG, Fernandez-Soto, ML, Salas-Salvado, J, Ballesteros-Pomar, MD, Ciudin, A, Torres, F, Vidal, C, Morales, MJ, Valdes, S, Pellitero, S, Minambres, I, Masmiquel, L, Goday, A, Suarez, L, Flores, L, Bueno, M, Caixas, A, Breton, I, Camara, R, Olbeyra, R, Penso, R, de la Cruz, MJ, Simo-Servat, A, Pereyra-Garcia, FM, Lopez-Mezquita, ET, Gils, A, Fidilio, E, Bandres, O, Martinez, A, Abuin, J, Marques-Pamies, M, Tuneu, L, Arteaga, M, Castaner, O, Goni, F, Arrizabalaga, C, Botana, MA, Calanas, A, Rebollo, A

Publicada: 1 abr 2020
Resumen:
Almost one third of patients do not achieve type 2 diabetes remission after bariatric surgery or are unable to sustain this effect long term. Our objective was to delve further into the dynamic responses of diabetes after bariatric surgery and to evaluate the "time-within-remission range" as a variable of metabolic control. A descriptive cohort study was done using a computerised multicentre and multidisciplinary registry. All data were adjusted by propensity score. A total of 1186 subjects with a follow-up of 4.5 +/- 2.5 years were included. Type of surgery, diabetes remission, recurrence of diabetes, "time-within-remission range" and key predictors of diabetes outcomes were assessed. All patients (70% women, 51.4 +/- 9.2 years old, body mass index (BMI) 46.3 +/- 6.9 kg/m(2)) underwent primary bariatric procedures. "Time-within-remission range" were 83.3% (33.3-91.6) after gastric bypass, 68.7% (7.1-87.5) after sleeve gastrectomy and 90% (83.3-92.8) after malabsorptive techniques (p < 0.001 for all). Duration of diabetes, baseline HbA1c and insulin treatment were significantly negatively correlated with the "time-within-remission range". The association of bariatric techniques with "time-within-remission range", using gastric bypass as a reference, were: odds ratio (OR) 3.70 (2.34-5.84), p < 0.001 for malabsorptive techniques and OR 0.55 (0.40-0.75), p < 0.001 for sleeve gastrectomy. Characteristics of type 2 diabetes powerfully influence the outcomes of bariatric surgery. The "time-within-remission range" unveils a superiority of gastric bypass compared to sleeve gastrectomy.

Filiaciones:
de Hollanda, A:
 Hosp Clin Barcelona, Barcelona 08036, Spain

 Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona 08036, Spain

 Inst Salud Carlos III ISCIII, CIBER Obesidad & Nutr CIBEROBN, Madrid 28029, Spain

Lecube, A:
 Univ Lleida, Inst Recerca Biomed Lleida IRBLleida, Hosp Univ Arnau Vilanova, Grp Recerca Obesitat, Lleida 25198, Spain

 Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metabol Asociadas CIB, Madrid 28029, Spain

Rubio, MA:
 Hosp Clin San Carlos IDISSC, Madrid 28040, Spain

Sanchez, E:
 Univ Lleida, Inst Recerca Biomed Lleida IRBLleida, Hosp Univ Arnau Vilanova, Grp Recerca Obesitat, Lleida 25198, Spain

Vilarrasa, N:
 Hosp Univ Bellvitge, Inst Invest Biomed Bellvitge IDIBELL, Barcelona 08907, Spain

Oliva, JG:
 Hosp Univ Nuestra Senora Candelaria, Santa Cruz De Tenerife 38010, Spain

Fernandez-Soto, ML:
 Hosp Clin San Carlos IDISSC, Madrid 28040, Spain

Salas-Salvado, J:
 Univ Rovita & Virgili Reus, Inst Invest Sanitaria Pere Virgili IISPV, Hosp Univ St Joan Reus, Tarragona 43204, Spain

Ballesteros-Pomar, MD:
 Hosp Univ San Cecilio, Granada 18016, Spain

 Hosp Leon, Leon 24008, Spain

 Complejo Hosp Univ Vigo, Vigo 36312, Spain

Ciudin, A:
 Hosp Univ Vall dHebron, Barcelona 08035, Spain

Torres, F:
 Hosp Clin Barcelona, Clin Pharmacol Deparment, Med Stat Core Facil, Barcelona 08036, Spain

 Univ Autonoma Barcelona, Biostat Unit, Fac Med, Barcelona 08193, Spain

Vidal, C:
 Hosp Royo Villanova, Zaragoza 50015, Spain

Morales, MJ:
 Complejo Hosp Univ Vigo, Vigo 36312, Spain

Valdes, S:
 Univ Malaga, Inst Invest Biomed Malaga IBIMA, Hosp Reg Univ Malaga, Malaga 29010, Spain

Pellitero, S:
 Hosp Univ Germans Trias Pujol, Inst Invest Germans Trias & IGTP, Badalona 08916, Spain

Minambres, I:
 Univ Autonoma Barcelona, Hosp Santa Creu & Sant Pau, Barcelona 08041, Spain

Masmiquel, L:
 Hosp Univ Son Llatzer, Inst Invest Sanitaria Ias Islas Baleares IdISBa, Palma de Mallorca 07198, Spain

Goday, A:
 Univ Autonoma Barcelona, Inst Hosp Mar Invest Mediques IMIM, Parc Salut Mar, Barcelona 08003, Spain

Suarez, L:
 Hosp Univ Cent Asturias, Oviedo 33011, Spain

Flores, L:
 Hosp Clin Barcelona, Barcelona 08036, Spain

 Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona 08036, Spain

 Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metabol Asociadas CIB, Madrid 28029, Spain

Bueno, M:
 Univ Lleida, Inst Recerca Biomed Lleida IRBLleida, Hosp Univ Arnau Vilanova, Grp Recerca Obesitat, Lleida 25198, Spain

Caixas, A:
 Univ Autonoma Barcelona, Inst Invest & Innovacio Parc Tauli I3PT, Hosp Univ Parc Tauli, Sabadell 08208, Spain

Breton, I:
 Hosp Gen Univ Gregorio Maranon, Inst Invest Sanitaria Gregorio Maranon IISGM, Madrid 28007, Spain

Camara, R:
 Hosp Univ & Politecn La Fe, Valencia 46026, Spain

Olbeyra, R:
 Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona 08036, Spain

Penso, R:
 Hosp Cent Defensa Gomez Ulla, Madrid 28047, Spain

de la Cruz, MJ:
 Hosp Univ Fdn Jimenez Diaz, Madrid 28040, Spain

Simo-Servat, A:
 Hosp Mutua Terrassa, Terrassa 08221, Spain

Pereyra-Garcia, FM:
 Hosp Univ Nuestra Senora Candelaria, Santa Cruz De Tenerife 38010, Spain

Lopez-Mezquita, ET:
 Hosp Univ San Cecilio, Granada 18016, Spain

Gils, A:
 Univ Rovita & Virgili Reus, Inst Invest Sanitaria Pere Virgili IISPV, Hosp Univ St Joan Reus, Tarragona 43204, Spain

Fidilio, E:
 Hosp Univ Vall dHebron, Barcelona 08035, Spain

Bandres, O:
 Hosp Royo Villanova, Zaragoza 50015, Spain

Martinez, A:
 Complejo Hosp Univ Vigo, Vigo 36312, Spain

Abuin, J:
 Univ Malaga, Inst Invest Biomed Malaga IBIMA, Hosp Reg Univ Malaga, Malaga 29010, Spain

Marques-Pamies, M:
 Hosp Univ Germans Trias Pujol, Inst Invest Germans Trias & IGTP, Badalona 08916, Spain

Tuneu, L:
 Hosp Univ Germans Trias Pujol, Inst Invest Germans Trias & IGTP, Badalona 08916, Spain

 Univ Autonoma Barcelona, Hosp Santa Creu & Sant Pau, Barcelona 08041, Spain

Arteaga, M:
 Hosp Univ Son Llatzer, Inst Invest Sanitaria Ias Islas Baleares IdISBa, Palma de Mallorca 07198, Spain

Castaner, O:
 Univ Autonoma Barcelona, Inst Hosp Mar Invest Mediques IMIM, Parc Salut Mar, Barcelona 08003, Spain

Goni, F:
 Hosp Basurto, Bilbao 48013, Spain

Arrizabalaga, C:
 Hosp Basurto, Bilbao 48013, Spain

Botana, MA:
 Hosp Univ Lucus Augusti, Lugo 27003, Spain

Calanas, A:
 Hosp Univ Reina Sofia, Cordoba 14004, Spain

Rebollo, A:
 Hosp Univ Reina Sofia, Cordoba 14004, Spain
ISSN: 20770383





Journal of Clinical Medicine
Editorial
MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND, Suiza
Tipo de documento: Article
Volumen: 9 Número: 4
Páginas:
WOS Id: 000531821000177
ID de PubMed: 32283783
imagen Green Published, gold

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