Adapting Cord Blood Collection and Banking Standard Operating Procedures for HLA-Homozygous Induced Pluripotent Stem Cells Production and Banking for Clinical Application
Por:
Alvarez-Palomo, B, Vives, J, Casaroli-Marano, RP, Gomez, SG, Gomez, LR, Edel, MJ, Giner, SQ
Publicada:
1 abr 2019
Resumen:
In this article, we will discuss the main aspects to be considered to define standard operation procedures (SOPs) for the creation of an induced pluripotent stem cell (iPSC) bank using cord blood (CB)or similar cell typebank guidelines for clinical aims. To do this, we adapt the pre-existing SOP for CB banking that can be complementary for iPSCs. Some aspects of iPSC manufacturing and the particular nature of these cells call for special attention, such as the potential multiple applications of the cells, proper explanation to the donor for consent of use, the genomic stability and the risk of genetic privacy disclosure. Some aspects of the iPSC SOP are solidly established by CB banking procedures, other procedures have good consensus in the scientific and medical community, while others still need to be further debated and settled. Given the international sharing vocation of iPSC banking, there is an urgent need by scientists, clinicians and regulators internationally to harmonize standards and allow future sample interchange between many iPSC bank initiatives that are springing up worldwide.
Filiaciones:
Alvarez-Palomo, B:
Banc Sang & Teixits, Edifici Dr Frederic Duran I Jorda, Barcelona 08005, Spain
Vives, J:
Banc Sang & Teixits, Edifici Dr Frederic Duran I Jorda, Barcelona 08005, Spain
Univ Autonoma Barcelona, Musculoskeletal Tissue Engn Grp, VHIR, Passeig Vall dHebron 129-139, Barcelona 08035, Spain
Univ Autonoma Barcelona, Dept Med, Passeig Vall dHebron 129-139, Barcelona 08035, Spain
Casaroli-Marano, RP:
Banc Sang & Teixits, Edifici Dr Frederic Duran I Jorda, Barcelona 08005, Spain
Univ Barcelona, Dept Surg, Sch Med, E-08036 Barcelona, Spain
Univ Barcelona, Hosp Clin Barcelona, E-08036 Barcelona, Spain
Inst Biomed Res St Pau IIB St Pau, Barcelona 08035, Spain
Gomez, SG:
Banc Sang & Teixits, Edifici Dr Frederic Duran I Jorda, Barcelona 08005, Spain
Gomez, LR:
Banc Sang & Teixits, Edifici Dr Frederic Duran I Jorda, Barcelona 08005, Spain
Edel, MJ:
Univ Barcelona, Fac Med, Inst Neurosci, Mol Genet & Control Pluripotency Lab,Dept Biomed, Casanova 143, E-08036 Barcelona, Spain
Victor Chang Cardiac Res Inst, Sydney, NSW 2145, Australia
Univ Western Australia, Harry Perkins Res Inst, CCTRM, Sch Med & Pharmacol, Perth, WA 6009, Australia
Univ Oxford, Dept Physiol Anat & Genet, Oxford OX3 7BN, England
Univ Autonoma Barcelona, Inst Univ Barraquer, Ctr Oftalmol Barraquer, E-08193 Barcelona, Spain
Giner, SQ:
Banc Sang & Teixits, Edifici Dr Frederic Duran I Jorda, Barcelona 08005, Spain
Univ Autonoma Barcelona, Musculoskeletal Tissue Engn Grp, VHIR, Passeig Vall dHebron 129-139, Barcelona 08035, Spain
Green Published, Green Submitted, gold
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