Modulation of the Gut Microbiota by Olive Oil Phenolic Compounds: Implications for Lipid Metabolism, Immune System, and Obesity
Por:
Farras, M, Martinez-Gili, L, Portune, K, Arranz, S, Frost, G, Tondo, M, Blanco-Vaca, F
Publicada:
1 ago 2020
Resumen:
There is extensive information of the beneficial effects of virgin olive oil (VOO), especially on cardiovascular diseases. Some VOO healthy properties have been attributed to their phenolic-compounds (PCs). The aim of this review is to present updated data on the effects of olive oil (OO) PCs on the gut microbiota, lipid metabolism, immune system, and obesity, as well as on the crosstalk among them. We summarize experiments and clinical trials which assessed the specific effects of the olive oil phenolic-compounds (OOPCs) without the synergy with OO-fats. Several studies have demonstrated that OOPC consumption increasesBacteroidetesand/or reduces theFirmicutes/Bacteroidetesratio, which have both been related to atheroprotection. OOPCs also increase certain beneficial bacteria and gut-bacteria diversity which can be therapeutic for lipid-immune disorders and obesity. Furthermore, some of the mechanisms implicated in the crosstalk between OOPCs and these disorders include antimicrobial-activity, cholesterol microbial metabolism, and metabolites produced by bacteria. Specifically, OOPCs modulate short-chain fatty-acids produced by gut-microbiota, which can affect cholesterol metabolism and the immune system, and may play a role in weight gain through promoting satiety. Since data in humans are scarce, there is a necessity for more clinical trials designed to assess the specific role of the OOPCs in this crosstalk.
Filiaciones:
Farras, M:
Inst Invest Biomed IIB St Pau, Inst Recerca Hosp Santa Creu & St Pau, Barcelona 08041, Spain
CIBER Diabet & Enfermedades Metab Asociadas CIBER, Barcelona 08907, Spain
Martinez-Gili, L:
Imperial Coll London, Fac Med, Dept Metab Digest & Reprod, Div Syst Med, London SW7 2AZ, England
Portune, K:
Basque Res & Technol Alliance BRTA, AZTI, Food Res, Parque Tecnol Bizkaia,Edificio 609, Derio 48160, Spain
Arranz, S:
Basque Res & Technol Alliance BRTA, AZTI, Food Res, Parque Tecnol Bizkaia,Edificio 609, Derio 48160, Spain
Frost, G:
Imperial Coll London, Fac Med, Dept Metab Digest & Reprod, Div Digest Dis, London SW7 2AZ, England
Tondo, M:
Hosp Santa Creu & Sant Pau, Serv Bioquim, Inst Invest Biomed IIB St Pau, Barcelona 08041, Spain
Blanco-Vaca, F:
CIBER Diabet & Enfermedades Metab Asociadas CIBER, Barcelona 08907, Spain
Hosp Santa Creu & Sant Pau, Serv Bioquim, Inst Invest Biomed IIB St Pau, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Bioquim & Biol Mol, Barcelona 08193, Spain
Green Published, gold, Green Submitted
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