Are mitochondrial haplogroups associated with elite athletic status? A study on a Spanish cohort
Por:
Nogales-Gadea, G, Pinos, T, Ruiz, JR, Marzo, PF, Fiuza-Luces, C, Lopez-Gallardo, E, Ruiz-Pesini, E, Martin, MA, Arenas, J, Moran, M, Andreu, AL, Lucia, A
Publicada:
1 nov 2011
Resumen:
There is increasing evidence regarding the association between mitochondrial DNA (mtDNA) and aerobic capacity; however, whether mtDNA haplogroups are associated with the status of being an elite endurance athlete is more controversial. We compared the frequency distribution of mtDNA haplogroups among the following groups of Spanish (Caucasian) men: 102 elite endurance athletes (professional road cyclists, endurance runners), 51 elite power athletes (jumpers, throwers and sprinters), and 478 non-athletic controls. We observed a significant difference between endurance athletes and controls (Fisher exact test = 17.89, P = 0.015; Bonferroni's significant threshold = 0.017). yet not between power athletes and controls (Fisher exact test = 47.99, P = 0.381) or between endurance and power athletes (Fisher exact test = 5.53, P = 0.597). We observed that the V haplogroup was overrepresented in endurance athletes (15.7%) compared with controls (7.5%) (odds ratio: 2.284; 95% confidence interval: 1.237, 4.322). In conclusion, our findings overall support the idea that mtDNA variations could be among the numerous contributors to the status of being an elite endurance athlete, whereas no association was found with elite power athletic status. (C) 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
Filiaciones:
Nogales-Gadea, G:
Inst Recerca Hosp Univ Vall dHebron, Dept Patol Mitocondrial & Neuromuscular, Barcelona, Spain
Univ Autonoma Barcelona, Lab Expt Neurol, Inst Recerca HSCSP, E-08193 Barcelona, Spain
Pinos, T:
Inst Recerca Hosp Univ Vall dHebron, Dept Patol Mitocondrial & Neuromuscular, Barcelona, Spain
Inst Salud Carlos III, CIBER Enfermedades Raras, Madrid, Spain
Ruiz, JR:
Univ Granada, Dept Phys Educ & Sport, Sch Phys Act & Sport Sci, Granada, Spain
Karolinska Inst, Dept Biosci & Nutr NOVUM, Unit Prevent Nutr, Stockholm, Sweden
Marzo, PF:
Univ Granada, Dept Biostat, Sch Med, Granada, Spain
Fiuza-Luces, C:
Univ Earopea Madrid, Madrid, Spain
Lopez-Gallardo, E:
Inst Salud Carlos III, CIBER Enfermedades Raras, Madrid, Spain
Univ Zaragoza, Dept Bioquim Biol Mol & Celular, Inst Aragones Ciencias Salud I CS, Zaragoza, Spain
Ruiz-Pesini, E:
Inst Salud Carlos III, CIBER Enfermedades Raras, Madrid, Spain
Univ Zaragoza, Dept Bioquim Biol Mol & Celular, Inst Aragones Ciencias Salud I CS, Zaragoza, Spain
Fdn ARAID, Zaragoza, Spain
Martin, MA:
Inst Salud Carlos III, CIBER Enfermedades Raras, Madrid, Spain
Inst Invest Hosp 12 Octubre i 12, Lab Enfermedades Mitocondriales & Neuromusculares, Madrid, Spain
Arenas, J:
Inst Salud Carlos III, CIBER Enfermedades Raras, Madrid, Spain
Inst Invest Hosp 12 Octubre i 12, Lab Enfermedades Mitocondriales & Neuromusculares, Madrid, Spain
Moran, M:
Inst Salud Carlos III, CIBER Enfermedades Raras, Madrid, Spain
Inst Invest Hosp 12 Octubre i 12, Lab Enfermedades Mitocondriales & Neuromusculares, Madrid, Spain
Andreu, AL:
Inst Recerca Hosp Univ Vall dHebron, Dept Patol Mitocondrial & Neuromuscular, Barcelona, Spain
Inst Salud Carlos III, CIBER Enfermedades Raras, Madrid, Spain
Lucia, A:
Univ Earopea Madrid, Madrid, Spain
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