Obstructive sleep apnoea and metabolic impairment in severe obesity
Por:
Gasa, M, Salord, N, Fortuna, AM, Mayos, M, Vilarrasa, N, Dorca, J, Montserrat, JM, Bonsignore, MR, Monasterio, C
Publicada:
1 nov 2011
Resumen:
Obstructive sleep apnoea (OSA) seems to worsen metabolism. This effect has not been evaluated in morbid obesity (MO). We hypothesised that the metabolic profile is more impaired in MO patients with OSA than in those without, and investigated whether any specific metabolic dysfunction is related to OSA in MO.
A prospective multicentre cross-sectional study was conducted in consecutive subjects before bariatric surgery. OSA was defined as apnoea/hypopnoea index (AHI) >= 15 by overnight polysomnography. Anthropometrical, blood pressure (BP) and fasting blood measurements were obtained the morning after. Metabolic syndrome (MetS) was defined according to National Cholesterol Education Program Adult Treatment Panel III modified criteria.
159 patients were studied: 72% were female and 72% had OSA. MetS prevalence was 70% in OSA versus 36% in non-OSA (p<0.001). As AHI severity increased, metabolic parameters progressively worsened, even in those without type 2 diabetes (DM2). AHI was independently associated with systolic and diastolic BP, triglycerides and the percentage of glycosylated haemoglobin (HbA1c) in the total sample, and with systolic BP, high-density lipoprotein cholesterol and HbA1c in those samples without DM2. OSA increased the adjusted odds ratio of having MetS by 2.8 (95% CI 1.3-6.2; p=0.009).
In MO, OSA is associated with major metabolic impairment caused by higher BP and poorer lipid and glucose control, independent of central obesity or DM2.
Filiaciones:
Gasa, M:
Hosp Univ Bellvitge, Dept Resp Med, Sleep Unit, Feixa Llarga, Hospitalet De L, Spain
Hosp Univ Bellvitge, Bellvitge Biomed Res Inst IDIBELL, Resp Med Sect, Lhospitalet De Llobregat, Spain
Univ Barcelona, Barcelona, Spain
Salord, N:
Hosp Univ Bellvitge, Dept Resp Med, Sleep Unit, Feixa Llarga, Hospitalet De L, Spain
Hosp Univ Bellvitge, Bellvitge Biomed Res Inst IDIBELL, Resp Med Sect, Lhospitalet De Llobregat, Spain
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Fortuna, AM:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Hosp Santa Creu & Sant Pau, Dept Resp Med, Sleep Unit, Barcelona, Spain
Mayos, M:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Hosp Santa Creu & Sant Pau, Dept Resp Med, Sleep Unit, Barcelona, Spain
Vilarrasa, N:
Hosp Univ Bellvitge, Dept Endocrinol & Nutr, Lhospitalet De Llobregat, Spain
Dorca, J:
Hosp Univ Bellvitge, Bellvitge Biomed Res Inst IDIBELL, Resp Med Sect, Lhospitalet De Llobregat, Spain
Montserrat, JM:
Univ Barcelona, Barcelona, Spain
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Hosp Clin Barcelona, Dept Resp Med, Sleep Unit, Barcelona, Spain
Bonsignore, MR:
Hosp Clin Barcelona, Dept Resp Med, Sleep Unit, Barcelona, Spain
Univ Palermo, Sect Pneumol, Biomed Dept Internal & Specialist Med DIBIMIS, I-90133 Palermo, Italy
Monasterio, C:
Hosp Univ Bellvitge, Dept Resp Med, Sleep Unit, Feixa Llarga, Hospitalet De L, Spain
Hosp Univ Bellvitge, Bellvitge Biomed Res Inst IDIBELL, Resp Med Sect, Lhospitalet De Llobregat, Spain
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Bronze, Green Published
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