Mortality and inherited thrombophilia: results from the European Prospective Cohort on Thrombophilia
Por:
Pabinger, I, Vossen, CY, Lang, J, Conard, J, Garcia-Dabrio, MC, Miesbach, W, Legnani, C, Svensson, P, Kaider, A, Rosendaal, FR
Publicada:
1 feb 2012
Resumen:
. Background: Data on the survival of individuals with hereditary thrombophilia are rare and only come from retrospective studies. Objective: The aim of the present study was to assess mortality in individuals with known thrombophilia with and without a history of thrombosis in comparison to a control group. Patients/methods: The European Prospective Cohort on Thrombophilia (EPCOT) study is a prospective, multi-center observational study performed to assess the risk of thrombosis in persons with inherited thrombophilia. In an extension of the present study, the vital status was assessed in 1240 individuals with thrombophilia (mean age 40.9 years, 59% women, 196 with antithrombin, 341 with protein C, 276 with protein S-deficiency, 330 with factor (F)V Leiden and 97 with combined defects, and 62% with a history of venous thrombosis [VT]) and 875 controls (mean age 42.5 years, 48% women, 7% with a history of VT). Results: Seventy-two individuals with thrombophilia and 45 controls died during follow-up. The risk of death, adjusted for gender, thrombosis history and center, was not associated with thrombophilia (hazard ratio [HR] thrombophilia individuals vs. controls: 1.09, 95% confidence interval [CI] 0.661.78). When individuals with thrombophilia were evaluated separately, a history of thrombosis was not associated with mortality: the risk of death after adjustment for gender, anticoagulation and center was HR 0.79 (95% CI, 0.411.54). Conclusions: No increased risk of death in individuals with thrombophilia, not even in those with a history of thrombosis, was observed.
Filiaciones:
Pabinger, I:
Med Univ Vienna, Clin Div Haematol & Haemostaseol, Dept Med 1, A-1090 Vienna, Austria
Vossen, CY:
Leiden Univ, Dept Clin Epidemiol, Med Ctr, Leiden, Netherlands
Univ Med Ctr Utrecht, Dept Med Genet, Div Biomed Genet, Utrecht, Netherlands
Lang, J:
Med Univ Vienna, Clin Div Haematol & Haemostaseol, Dept Med 1, A-1090 Vienna, Austria
Conard, J:
Hop Hotel Dieu, Dept Biol Hematol, F-75181 Paris, France
Garcia-Dabrio, MC:
Hosp Santa Creu & Sant Pau, Unitat Hemostasia & Trombosi, Dept Hematol, Barcelona, Spain
Miesbach, W:
Goethe Univ Frankfurt, Inst Transfus Med, Med Clin 3, Hemophilia Ctr, D-6000 Frankfurt, Germany
Legnani, C:
Univ Hosp S Orsola Malpighi, Dept Angiol & Blood Coagulat Marino Golinelli, Bologna, Italy
Svensson, P:
Lund Univ, Univ Hosp, Dept Coagulat Disorders, Malmo, Sweden
Kaider, A:
Med Univ Vienna, Ctr Med Stat Informat & Intelligent Syst, Sect Clin Biometr, A-1090 Vienna, Austria
Rosendaal, FR:
Leiden Univ, Med Ctr, Dept Clin Epidemiol Thrombosis & Haemostasis, Leiden, Netherlands
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