Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus
Por:
Tavira, B, Coto, E, Torres, A, Diaz-Corte, C, Diaz-Molina, B, Ortega, F, Arias, M, Diaz, JM, Selgas, R, Lopez-Larrea, C, Ruiz-Ortega, M, Ortiz, A, Gonzalez, E, Campistol, JM, Alvarez, V
Publicada:
1 mar 2012
Resumen:
KCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA + AG genotypes were significantly associated with NODAT-risk (p = 0.004; OR = 2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association. (C) 2011 Elsevier Inc. All rights reserved.
Filiaciones:
Tavira, B:
Hosp Univ Cent Asturias, Oviedo 33006, Spain
Coto, E:
Hosp Univ Cent Asturias, Oviedo 33006, Spain
Fdn Renal I Alvarez Toledo, Madrid, Spain
Torres, A:
Univ La Laguna, Hosp Univ Canarias, Unidad Invest, Tenerife, Spain
Hosp Clin Barcelona, Barcelona, Spain
Diaz-Corte, C:
Hosp Univ Cent Asturias, Oviedo 33006, Spain
Diaz-Molina, B:
Hosp Univ Cent Asturias, Oviedo 33006, Spain
Ortega, F:
Hosp Univ Cent Asturias, Oviedo 33006, Spain
Hosp Clin Barcelona, Barcelona, Spain
Fdn Renal I Alvarez Toledo, Madrid, Spain
Arias, M:
Hosp Univ Valdecilla, Santander, Spain
Hosp Clin Barcelona, Barcelona, Spain
Diaz, JM:
Fdn Puigvert, Barcelona, Spain
Selgas, R:
Hosp Univ La Paz, Madrid, Spain
Hosp Clin Barcelona, Barcelona, Spain
Lopez-Larrea, C:
Hosp Univ Cent Asturias, Oviedo 33006, Spain
Hosp Clin Barcelona, Barcelona, Spain
Ruiz-Ortega, M:
Fdn Jimenez Diaz, Cellular Biol Renal Dis Lab, Madrid, Spain
Univ Autonoma Madrid, E-28049 Madrid, Spain
Ortiz, A:
Fdn Jimenez Diaz, Cellular Biol Renal Dis Lab, Madrid, Spain
Univ Autonoma Madrid, E-28049 Madrid, Spain
Gonzalez, E:
Hosp Univ La Paz, Madrid, Spain
Campistol, JM:
Hosp Clin Barcelona, Barcelona, Spain
Alvarez, V:
Hosp Univ Cent Asturias, Oviedo 33006, Spain
Open Access
|