Is adiponectin a marker of preclinical atherosclerosis in kidney transplantation?
Por:
Canas, L, Bayes, B, Granada, ML, Ibernon, M, Porrini, E, Benitez, R, Diaz, JM, Lauzurica, R, Moreso, F, Torres, A, Lampreabe, I, Serra, A, Romero, R
Publicada:
1 mar 2012
Resumen:
The aim of this study was to analyze the relationship between pre-transplant adiponectin (pre-ADP), abnormalities in glucose homeostasis (AGH) at three months post-transplantation, and preclinical atherosclerosis in non-diabetic patients prior to kidney transplantation (KT).
Methods: We carried out a multicenter study in 157 non-diabetic KT patients (66.5% men; age: 50 +/- 13 yr). Pre-ADP levels were analyzed using radioimmunoassay. Carotid ultrasound was performed to determine carotid intima-media thickness (c-IMT). Oral glucose tolerance test was carried out to classify patients according ADA criteria.
Results: Of the patients, 52.8% had AGH. Median pre-ADP was 19.5 (1427) mu g/mL. An inverse correlation was found between ADP and HOMA index (r =-0.432; p < 0.001). Median c-IMT was 0.6 (0.48-0.71) mm. Significant inverse correlation existed between ADP and c-IMT on both sides (p < 0.05). Patients with c-IMT > 0.6 mm had more AGH (p = 0.012) and lower ADP levels (p = 0.02). We performed a logistic regression analysis using preclinical atherosclerosis (c-IMT >= 0.6 mm) as dependent variable and sex, age, BMI, ADP, AGH, and HOMA index as independent variables of altered c-IMT. Age, pre-ADP, and AGH were independent risk factors for elevated c-IMT.
Conclusions: Patients with AGH have a greater presence of preclinical atherosclerosis. ADP has an inverse relationship with AGH and is an independent marker of preclinical atherosclerosis.
Filiaciones:
Canas, L:
UAB, Hosp Germans Trias & Pujol, Dept Nephrol, Badalona 08916, Barcelona, Spain
Bayes, B:
UAB, Hosp Germans Trias & Pujol, Dept Nephrol, Badalona 08916, Barcelona, Spain
Granada, ML:
Hosp Badalona Germans Trias & Pujol, Dept Biochem, Barcelona, Spain
Ibernon, M:
Bellvitge Hosp, Dept Nephrol, Barcelona, Spain
Porrini, E:
Hosp Univ Canarias, Res Unit, San Cristobal la Laguna, Spain
Benitez, R:
Hosp Cruces, Dept Nephrol, Bilbao, Spain
Diaz, JM:
Fundacio Puigvert, Dept Nephrol, Barcelona, Spain
Lauzurica, R:
UAB, Hosp Germans Trias & Pujol, Dept Nephrol, Badalona 08916, Barcelona, Spain
Moreso, F:
Bellvitge Hosp, Dept Nephrol, Barcelona, Spain
Torres, A:
Univ La Laguna, Dept Nephrol, Hosp Univ Canarias, E-38207 San Cristobal la Laguna, Spain
Lampreabe, I:
Hosp Cruces, Dept Nephrol, Bilbao, Spain
Serra, A:
UAB, Hosp Germans Trias & Pujol, Dept Nephrol, Badalona 08916, Barcelona, Spain
Romero, R:
UAB, Hosp Germans Trias & Pujol, Dept Nephrol, Badalona 08916, Barcelona, Spain
|