Primary cutaneous diffuse large B-cell lymphoma, leg type and secondary cutaneous involvement by testicular B-cell lymphoma share identical clinicopathological and immunophenotypical features
Por:
Muniesa, C, Pujol, RM, Estrach, MT, Gallardo, F, Garcia-Muret, MI, Climent, J, Salar, A, Servitje, O
Publicada:
1 abr 2012
Resumen:
Background: Primary cutaneous diffuse large B-cell lymphoma (PCDLBCL), leg type can eventually disseminate to extracutaneous sites including testes. In addition, patients with testicular lymphoma can develop specific skin involvement.
Objective: We sought to describe similarities between PCDLBCL, leg type and testicular B-cell lymphoma affecting the skin.
Methods: We report two cases with typical clinicopathological and immunophenotypical features of leg type lymphoma occurring simultaneously with a testicular B-cell lymphoma. We also report an additional case of PCDLBCL, leg type with secondary testicular involvement.
Results: All cases presented with typical red tumors exclusively located on the legs. Histologically, all cases showed a diffuse nonepidermotropic infiltrate composed of large blastic cells mainly centroblastic type. Phenotype showed strong positivity for Bcl-2, MUM-1, and FOXP1. Epstein-Barr virus stains and CD30 were negative in the 3 cases. In all cases the testicular infiltration showed the same pathological and phenotypical changes to those observed in the skin.
Limitations: This was a retrospective case series study.
Conclusion: Skin involvement by testicular B-cell lymphomas and PCDLBCL, leg type are indistinguishable on the basis of pathologic and immunophenotypical features, therefore specific investigation and clinic correlation are needed. (J Am Acad Dermatol 2012;66:650-4.)
Filiaciones:
Muniesa, C:
Hosp Viladecans, Dept Dermatol, Viladecans, Spain
Garcia-Muret, MI:
Hosp Santa Creu & Sant Pau, Dept Dermatol, Barcelona, Spain
Climent, J:
Hosp Univ Bellvitge, Inst Invest Biomed Bellvitge IDIBELL, Dept Pathol, Lhospitalet De Llobregat, Spain
Servitje, O:
Hosp Univ Bellvitge, Inst Invest Biomed Bellvitge IDIBELL, Dept Dermatol, Lhospitalet De Llobregat, Spain
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