A European multicentre photopatch test study The European Multicentre Photopatch Test Study (EMCPPTS) Taskforce
Por:
Kerr, AC, Ferguson, J, Haylett, AK, Rhodes, LE, Adamski, H, Alomar, A, Serra, E, Antoniou, C, Aubin, F, Vigan, M, Biedermann, T, Fischer, J, Bourrain, JL, Bruynzeel, D, Rustemeyer, T, Carrascosa, JM, Chowdhury, MMU, de la Cuadra, J, Foti, C, Gardeazabal, J, Gawkrodger, DJ, Gimenez-Arnau, A, Goncalo, M, Goossens, A, Ibbotson, SH, Dawe, RS, Lecha, M, Marguery, MC, Neumann, NJ, Niklasson, B, Peyron, JL, Pigatto, P, Spiewak, R, Stone, N, Tanew, A, Thomas, P, Bonnevalle, A, Wilkinson, SM, Wolf, P, Gruber-Wackernagel, A, Wulf, HC
Publicada:
1 may 2012
Resumen:
Background The two most common agent groups currently responsible for photo-allergic contact dermatitis (PACD) are organic ultraviolet (UV) absorbers in sunscreens and topical nonsteroidal anti-inflammatory drugs (NSAIDs). However, availability of information on the photoallergenic potential of these agents is scarce.
Objectives To obtain current information on the frequency of PACD to 19 organic UV absorbers and five topical NSAIDs, including newer agents, in common usage in Europe.
Methods A prospective, multicentre photopatch test study was conducted with 1031 patients attending for investigation of suspected PACD in 30 centres across 12 European countries.
Results A total of 346 PACD reactions in 200 (19.4%) subjects occurred. PACD was most commonly caused by the topical NSAIDs, ketoprofen (128 subjects) and etofenamate (59 subjects). Of the organic UV absorbers, octocrylene, benzophenone-3 and butyl methoxydibenzoylmethane most frequently elicited PACD. The 'newer' organic sunscreen absorbers rarely led to PACD. There appeared to be an association between the agents ketoprofen, octocrylene and benzophenone-3, with several subjects developing PACD to two or all three agents concomitantly. Allergic contact dermatitis (ACD) was less commonly observed than PACD, comprising 55 reactions in 47 (5%) subjects. Irritant reactions and photoaugmentation and photoinhibition of ACD occurred infrequently.
Conclusions The European multicentre photopatch test study has provided current information on the relative frequency of PACD to common photoallergens. Such data will be of value when deciding on which agents to include in a future European 'baseline' photopatch test series.
Filiaciones:
Kerr, AC:
Ninewells Hosp, Dept Dermatol, Photobiol Unit, Dundee DD1 9SY, Scotland
Haylett, AK:
Univ Manchester, Salford Royal NHS Fdn Trust, Manchester, Lancs, England
Rhodes, LE:
Univ Manchester, Salford Royal NHS Fdn Trust, Manchester, Lancs, England
Adamski, H:
Univ Rennes, Rennes, France
Alomar, A:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Serra, E:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Antoniou, C:
Andeas Sygros Hosp, Athens, Greece
Aubin, F:
Univ Hosp, Besancon, France
Vigan, M:
Univ Hosp, Besancon, France
Biedermann, T:
Univ Tubingen, D-72074 Tubingen, Germany
Fischer, J:
Univ Tubingen, D-72074 Tubingen, Germany
Bourrain, JL:
Univ Grenoble, Grenoble, France
Bruynzeel, D:
Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands
Rustemeyer, T:
Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands
Carrascosa, JM:
Hosp Badalona Germans Trias & Pujol, Badalona, Spain
Chowdhury, MMU:
Univ Wales Hosp, Cardiff CF4 4XW, S Glam, Wales
de la Cuadra, J:
Gen Hosp, Valencia, Spain
Foti, C:
Univ Bari, Bari, Italy
Gardeazabal, J:
Hosp Cruces, Bilbao, Spain
Gawkrodger, DJ:
Royal Hallamshire Hosp, Sheffield S10 2JF, S Yorkshire, England
Gimenez-Arnau, A:
Univ Autonoma Barcelona, Hosp Mar, E-08193 Barcelona, Spain
Goncalo, M:
Univ Coimbra, Coimbra, Portugal
Goossens, A:
Univ Hosp, Louvain, Belgium
Lecha, M:
Univ Barcelona, Barcelona, Spain
Marguery, MC:
Larrey Univ Hosp, Toulouse, France
Neumann, NJ:
Univ Dusseldorf, D-40225 Dusseldorf, Germany
Niklasson, B:
Chemotech Diagnost, Vellinge, Sweden
Peyron, JL:
Hop St Eloi, Montpellier, France
Pigatto, P:
Univ Milan, IRCCS Galeazzi Hosp, Milan, Italy
Spiewak, R:
Jagiellonian Univ, Krakow, Poland
Stone, N:
Royal Gwent Hosp, Newport, Shrops, England
Tanew, A:
Med Univ Vienna, Vienna, Austria
Thomas, P:
Hop Claude Huriez, Lille, France
Bonnevalle, A:
Hop Claude Huriez, Lille, France
Wilkinson, SM:
Leeds Gen Infirm, Leeds, W Yorkshire, England
Wolf, P:
Med Univ Graz, Graz, Austria
Gruber-Wackernagel, A:
Med Univ Graz, Graz, Austria
Wulf, HC:
Univ Copenhagen, Bispebjerg Hosp, Copenhagen, Denmark
Open Access
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