Assessing the effect of patterns of cocaine and alcohol use on the risk of adverse acute cocaine intoxication
Por:
Santos, S, Brugal, MT, Barrio, G, Castellano, Y, Domingo-Salvany, A, Espelt, A, Bravo, MJ, de la Fuente, L
Publicada:
1 jun 2012
Resumen:
Introduction and Aims. Although, in the laboratory, most acute adverse effects of cocaine are dose-dependent and alcohol potentiates some of these effects, there are few observational studies, and scarce awareness that the risk of acute cocaine intoxication (ACI) can increase as the amounts of cocaine and alcohol consumed increase. Our objectives were to assess if the risk of ACI increases with the level cocaine use, both in chronic and binge use; and also to determine whether it increases when a cocaine binge is combined with binge drinking or with regular excessive drinking. Design and Methods. Hypotheses were evaluated using logistic regression and case-crossover analyses in a sample of 720 young regular cocaine users who did not regularly use heroin, recruited at drug scenes in 20042006. All data on ACI, predictor and confounding variables were obtained through a computer-assisted personal interview. Results. The annual prevalence of ACI was 21%. In the last year 10.3% of the participants reported cocaine binges (=0.5 g in 4 h). ACI risk increased considerably in the 4 h following a cocaine binge (odds ratio = 34.6; 95% confidence interval 11.5170.8). Also, it increased with increases in the average level of cocaine used over a long period and when users regularly drank excessively. Finally, the results suggest that the high risk of ACI associated with cocaine binge may increase even more when combined with binge drinking. Discussion and Conclusions. Awareness of the dose-dependent effect of cocaine on ACI risk, as well as the possible synergistic effect of alcohol, ought to be incorporated into preventive and care strategies.[Santos S, Brugal MT, Barrio G, Castellano Y, Domingo-Salvany A, Espelt A, Bravo MJ, de la Fuente L, the ITINERE Project Group. Assessing the effect of patterns of cocaine and alcohol use on the risk of adverse acute cocaine intoxication. Drug Alcohol Rev 2012;31:439446]
Filiaciones:
Santos, S:
Carlos III Hlth Inst, Natl Epidemiol Ctr, Madrid, Spain
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Barcelona, Spain
Brugal, MT:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Barcelona, Spain
Agencia Salut Publ Barcelona, Barcelona 08023, Spain
Biomed Res Inst St Pau IIB St Pau, Barcelona, Spain
Barrio, G:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Barcelona, Spain
Carlos III Hlth Inst, Natl Sch Publ Hlth, Madrid, Spain
Castellano, Y:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Barcelona, Spain
Agencia Salut Publ Barcelona, Barcelona 08023, Spain
Biomed Res Inst St Pau IIB St Pau, Barcelona, Spain
Domingo-Salvany, A:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Barcelona, Spain
IMIM Hosp Mar, Drug Abuse Epidemiol Res Grp, Barcelona, Spain
Espelt, A:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Barcelona, Spain
Agencia Salut Publ Barcelona, Barcelona 08023, Spain
Biomed Res Inst St Pau IIB St Pau, Barcelona, Spain
Bravo, MJ:
Carlos III Hlth Inst, Natl Epidemiol Ctr, Madrid, Spain
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Barcelona, Spain
de la Fuente, L:
Carlos III Hlth Inst, Natl Epidemiol Ctr, Madrid, Spain
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Barcelona, Spain
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