Awareness of Diagnosis in Persons with Early-Stage Alzheimer's Disease: An Observational Study in Spain
Por:
Villarejo-Galende, A, Garcia-Arcelay, E, Pinol-Ripoll, G, del Olmo-Rodriguez, A, Vinuela, F, Boada, M, Franco-Macias, E, de la Pena, AI, Riverol, M, Puig-Pijoan, A, Abizanda-Soler, P, Arroyo, R, Baquero-Toledo, M, Feria-Vilar, I, Balasa, M, Berbel, A, Rodriguez-Rodriguez, E, Vieira-Campos, A, Garcia-Ribas, G, Rodrigo-Herrero, S, Lleo, A, Maurino, J
Publicada:
1 sep 2022
Ahead of Print:
1 jun 2022
Resumen:
Introduction Limited information is available on people's experiences of living with Alzheimer's disease (AD) at earlier stages. This study assessed awareness of diagnosis among people with early-stage AD and its impact on different person-centered outcome measures. Methods We conducted an observational, cross-sectional study in 21 memory clinics in Spain. Persons aged 50-90 years, diagnosed with prodromal or mild AD (NIA/AA criteria), a Mini Mental State Examination (MMSE) score >= 22, and a Clinical Dementia Rating-Global score (CDR-GS) of 0.5 or 1.0 were recruited. The Representations and Adjustment to Dementia Index (RADIX) was used to assess participants' beliefs about their condition and its consequences. Results A total of 149 persons with early-stage AD were studied. Mean (SD) age was 72.3 (7.0) years and 50.3% were female. Mean duration of AD was 1.4 (1.8) years. Mean MMSE score was 24.6 (2.1) and 87.2% had a CDR-GS score of 0.5. Most participants (n = 84, 57.5%) used a descriptive term related to specific AD symptoms (e.g., memory difficulties) when asked what they called their condition. Participants aware of their diagnosis using the term AD (n = 66, 45.2%) were younger, had more depressive symptoms, and poorer life satisfaction and quality of life compared to those without awareness of their specific diagnosis. Practical and emotional consequences RADIX scores showed a significant negative correlation with Quality of Life in Alzheimer's Disease score (rho = - 0.389 and - 0.413, respectively; p < 0.0001). Years of education was the only predictor of awareness of AD diagnosis [OR = 1.04 (95% CI 1.00-1.08); p = 0.029]. Conclusions Awareness of diagnosis was a common phenomenon in persons with early-stage AD negatively impacting their quality of life. Understanding illness representations in earlier stages may facilitate implementing optimized care that supports improved quality of life and well-being.
Filiaciones:
Villarejo-Galende, A:
Hosp Univ 12 Octubre, Inst Invest Hosp 12 Octubre I 12, Dept Neurol, CIBERNED, Madrid, Spain
Garcia-Arcelay, E:
Roche Farma, Med Dept, Ribera Loira 50, Madrid 28042, Spain
Pinol-Ripoll, G:
Hosp Univ Santa Maria, Inst Recerca Biomed Lleida IRBLLeida, Unitat Trastorns Cognitius, Lleida, Spain
del Olmo-Rodriguez, A:
Hosp Univ Dr Peset, Dept Neurol, Valencia, Spain
Vinuela, F:
Hosp Univ Virgen Macarena, Hosp Victoria Eugenia, Inst Neurol Andaluz, Unidad Deterioro Cognit, Seville, Spain
Boada, M:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, CIBERNED, Barcelona, Spain
Franco-Macias, E:
Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Dept Neurol, Dementia Unit, Seville, Spain
de la Pena, AI:
Policlin Guipuzcoa, Ctr Invest Parkinson, San Sebastian, Spain
Riverol, M:
Clin Univ Navarra, Dept Neurol, Pamplona, Spain
Puig-Pijoan, A:
Hosp Mar Med Res Inst IMIM, Dept Neurol, Cognit Impairment & Movement Disorders Unit, Barcelona, Spain
Abizanda-Soler, P:
Complejo Hosp Univ Albacete, Dept Geriatr, Albacete, Spain
Arroyo, R:
Hosp Univ Quironsalud, Dept Neurol, Madrid, Spain
Baquero-Toledo, M:
Hosp Univ & Politecn La Fe, Inst Invest Sanitaria La Fe, Dept Neurol, Valencia, Spain
Feria-Vilar, I:
Complejo Hosp Univ Albacete, Dept Neurol, Albacete, Spain
Balasa, M:
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Hosp Clin, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain
Berbel, A:
Hosp Cent Cruz Roja, Dept Neurol, Madrid, Spain
Rodriguez-Rodriguez, E:
Hosp Univ Marques Valdecilla, Inst Invest Sanitaria Valdecilla IDIVAL, Dept Neurol, Santander, Spain
Vieira-Campos, A:
Hosp Univ La Princesa, Dept Neurol, Madrid, Spain
Garcia-Ribas, G:
Hosp Univ Ramon y Cajal, Dept Neurol, Madrid, Spain
Rodrigo-Herrero, S:
Hosp Univ Juan Ramon Jimenez, Dept Neurol, Huelva, Spain
Lleo, A:
Univ Autonoma Barcelona, Dept Neurol, Memory Unit, Hosp La Santa Creu & St Pau,Biomed Res Inst St Pa, Barcelona, Spain
Maurino, J:
Roche Farma, Med Dept, Ribera Loira 50, Madrid 28042, Spain
gold, All Open Access, Gold
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