Metabolic polygenic risk scores effect on antipsychotic-induced metabolic dysregulation: A longitudinal study in a first episode psychosis cohort
Por:
Segura, AG, Martinez-Pinteno, A, Gasso, P, Rodriguez, N, Bioque, M, Cuesta, MJ, Gonzalez-Penas, J, Garcia-Rizo, C, Lobo, A, Gonzalez-Pinto, A, Garcia-Alcon, A, Roldan, A, Vista, E, Castro-Fornieles, J, Mane, A, Saiz, J, Bernardo, M, Mas, S
Publicada:
1 jun 2022
Ahead of Print:
1 may 2022
Resumen:
Objective: Metabolic syndrome is a health-threatening condition suffered by approximately one third of schizophrenia patients and largely attributed to antipsychotic medication. Previous evidence reports a common genetic background of psychotic and metabolic disorders. In this study, we aimed to assess the role of polygenic risk scores (PRSs) on the progression of the metabolic profile in a first-episode psychosis (FEP) cohort. Method: Of the 231 FEP individuals included in the study, 192-220 participants were included in basal analysis and 118-179 in longitudinal 6-month models. Eleven psychopathologic and metabolic PRSs were constructed. Basal and longitudinal PRSs association with metabolic measurements was assessed by statistical analyses.Results: No major association of psychopathological PRSs with the metabolic progression was found. However, high risk individuals for depression and cholesterol-related PRSs reported a higher increase of cholesterol levels during the follow-up (FDR <= 0.023 for all analyses). Their effect was comparable to other well-established pharmacological and environmental risk factors (explaining at least 1.2% of total variance).Conclusion: Our findings provide new evidence of the effects of metabolic genetic risk on the development of metabolic dysregulation. The future establishment of genetic profiling tools in clinical procedures could enable practitioners to better personalize antipsychotic treatment selection and dosage.
Filiaciones:
Segura, AG:
Univ Barcelona, Dept Clin Fdn, Pharmacol Unit, Barcelona 08036, Spain
Martinez-Pinteno, A:
Univ Barcelona, Dept Clin Fdn, Pharmacol Unit, Barcelona 08036, Spain
Gasso, P:
Univ Barcelona, Dept Clin Fdn, Pharmacol Unit, Barcelona 08036, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona 08036, Spain
Rodriguez, N:
Univ Barcelona, Dept Clin Fdn, Pharmacol Unit, Barcelona 08036, Spain
Bioque, M:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona 08036, Spain
Hosp Clin Barcelona, Barcelona Clin Schizophrenia Unit, Neurosci Inst, Barcelona 08036, Spain
Cuesta, MJ:
Complejo Hosp Navarra, Dept Psychiat, Pamplona 31008, Spain
Navarra Inst Hlth Res IdiSNA, Pamplona, Spain
Gonzalez-Penas, J:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain
Inst Invest Sanitaria Gregorio Maran IiSGM, Hosp Gen Univ Gregorio Maranon, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat, Madrid 28007, Spain
Garcia-Rizo, C:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona 08036, Spain
Hosp Clin Barcelona, Barcelona Clin Schizophrenia Unit, Neurosci Inst, Barcelona 08036, Spain
Lobo, A:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain
Univ Zaragoza, Dept Med & Psychiat, Zaragoza 50009, Spain
Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza 50009, Spain
Gonzalez-Pinto, A:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain
Hosp Univ Alava, Vitoria 01009, Spain
Inst Invest Sanitaria Bioaraba, Vitoria 01009, Spain
Univ Basque Country, Vizcaya 48940, Spain
Garcia-Alcon, A:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain
Inst Invest Sanitaria Gregorio Maran IiSGM, Hosp Gen Univ Gregorio Maranon, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat, Madrid 28007, Spain
Roldan, A:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Inst Invest Biomed St Pau IIB SANTPAU, Psychiat Dept, Barcelona 08041, Spain
Vista, E:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain
Hosp Clin Barcelona, Barcelona 08036, Spain
Univ Barcelona, Dept Med, Barcelona 08036, Spain
Castro-Fornieles, J:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain
Hosp Clin Barcelona, Clin Inst Neurosci, Dept Child & Adolescent Psychiat & Psychol, Barcelona 08036, Spain
Mane, A:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain
Autonomous Univ Barcelona, Hosp del Mar Med Res Inst IMIM, Barcelona 08003, Spain
Saiz, J:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain
Univ Alcala de Henares, Hosp Univ Ramon & Cajal, IRYCIS, Madrid 28034, Spain
Bernardo, M:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain
Hosp Clin Barcelona, Barcelona Clin Schizophrenia Unit, Neurosci Inst, Barcelona 08036, Spain
Univ Barcelona, Dept Med, Barcelona 08036, Spain
Mas, S:
Univ Barcelona, Dept Clin Fdn, Pharmacol Unit, Barcelona 08036, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain
hybrid, All Open Access, Hybrid Gold
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