Extracellular Vesicles as Drivers of Immunoinflammation in Atherothrombosis
Por:
Suades, R, Greco, MF, Padro, T, Badimon, L
Publicada:
1 jun 2022
Resumen:
Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality all over the world. Extracellular vesicles (EVs), small lipid-bilayer membrane vesicles released by most cellular types, exert pivotal and multifaceted roles in physiology and disease. Emerging evidence emphasizes the importance of EVs in intercellular communication processes with key effects on cell survival, endothelial homeostasis, inflammation, neoangiogenesis, and thrombosis. This review focuses on EVs as effective signaling molecules able to both derail vascular homeostasis and induce vascular dysfunction, inflammation, plaque progression, and thrombus formation as well as drive anti-inflammation, vascular repair, and atheroprotection. We provide a comprehensive and updated summary of the role of EVs in the development or regression of atherosclerotic lesions, highlighting the link between thrombosis and inflammation. Importantly, we also critically describe their potential clinical use as disease biomarkers or therapeutic agents in atherothrombosis.
Filiaciones:
Suades, R:
Res Inst Hosp Santa Creu & St Pau, Cardiovasc ICCC Program, IIB St Pau, Barcelona 08025, Spain
Greco, MF:
Res Inst Hosp Santa Creu & St Pau, Cardiovasc ICCC Program, IIB St Pau, Barcelona 08025, Spain
Univ Milan, Dept Pharmacol & Biomol Sci, I-20133 Milan, Italy
Padro, T:
Res Inst Hosp Santa Creu & St Pau, Cardiovasc ICCC Program, IIB St Pau, Barcelona 08025, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Cardiovasc CIBERCV, Madrid 28029, Spain
Badimon, L:
Res Inst Hosp Santa Creu & St Pau, Cardiovasc ICCC Program, IIB St Pau, Barcelona 08025, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Cardiovasc CIBERCV, Madrid 28029, Spain
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