A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers
Por:
Ding, YC, McGuffog, L, Healey, S, Friedman, E, Laitman, Y, Shani-Paluch-Shimon, Kaufman, B, Liljegren, A, Lindblom, A, Olsson, H, Kristoffersson, U, Stenmark-Askmalm, M, Melin, B, Domchek, SM, Nathanson, KL, Rebbeck, TR, Jakubowska, A, Lubinski, J, Jaworska, K, Durda, K, Gronwald, J, Huzarski, T, Cybulski, C, Byrski, T, Osorio, A, Cajal, TR, Stavropoulou, AV, Benitez, J, Hamann, U, Rookus, M, Aalfs, CM, de Lange, JL, Meijers-Heijboer, HEJ, Oosterwijk, JC, van Asperen, CJ, Garcia, EBG, Hoogerbrugge, N, Jager, A, van der Luijt, RB, Easton, DF, Peock, S, Frost, D, Ellis, SD, Platte, R, Fineberg, E, Evans, DG, Lalloo, F, Izatt, L, Eeles, R, Adlard, J, Davidson, R, Eccles, D, Cole, T, Cook, J, Brewer, C, Tischkowitz, M, Godwin, AK, Pathak, H, Stoppa-Lyonnet, D, Sinilnikova, OM, Mazoyer, S, Barjhoux, L, Leone, M, Gauthier-Villars, M, Caux-Moncoutier, V, de Pauw, A, Hardouin, A, Berthet, P, Dreyfus, H, Ferrer, SF, Collonge-Rame, MA, Sokolowska, J, Buys, S, Daly, M, Miron, A, Terry, MB, Chung, W, John, EM, Southey, M, Goldgar, D, Singer, CF, Tea, MKM, Gschwantler-Kaulich, D, Fink-Retter, A, Hansen, TVO, Ejlertsen, B, Johannsson, OT, Offit, K, Sarrel, K, Gaudet, MM, Vijai, J, Robson, M, Piedmonte, MR, Andrews, L, Cohn, D, DeMars, LR, DiSilvestro, P, Rodriguez, G, Toland, AE, Montagna, M, Agata, S, Imyanitov, E, Isaacs, C, Janavicius, R, Lazaro, C, Blanco, I, Ramus, SJ, Sucheston, L, Karlan, BY, Gross, J, Ganz, PA, Beattie, MS, Schmutzler, RK, Wappenschmidt, B, Meindl, A, Arnold, N, Niederacher, D, Preisler-Adams, S, Gadzicki, D, Varon-Mateeva, R, Deissler, H, Gehrig, A, Sutter, C, Kast, K, Nevanlinna, H, Aittomaki, K, Simard, J, Spurdle, AB, Beesley, J, Chen, XQ, Tomlinson, GE, Weitzel, J, Garber, JE, Olopade, OI, Rubinstein, WS, Tung, N, Blum, JL, Narod, SA, Brummel, S, Gillen, DL, Lindor, N, Fredericksen, Z, Pankratz, VS, Couch, FJ, Radice, P, Peterlongo, P, Greene, MH, Loud, JT, Mai, PL, Andrulis, IL, Glendon, G, Ozcelik, H, Gerdes, AM, Thomassen, M, Jensen, UB, Skytte, AB, Caligo, MA, Lee, A, Chenevix-Trench, G, Antoniou, AC, Neuhausen, SL
Publicada:
1 ago 2012
Resumen:
Background: We previously reported significant associations between genetic variants in insulin receptor substrate 1 (IRS1) and breast cancer risk in women carrying BRCA1 mutations. The objectives of this study were to investigate whether the IRS1 variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of BRCA1 and BRCA2 mutation carriers.
Methods: IRS1 rs1801123, rs1330645, and rs1801278 were genotyped in samples from 36 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Data were analyzed by a retrospective cohort approach modeling the associations with breast and ovarian cancer risks simultaneously. Analyses were stratified by BRCA1 and BRCA2 status and mutation class in BRCA1 carriers.
Results: Rs1801278 (Gly972Arg) was associated with ovarian cancer risk for both BRCA1 (HR, 1.43; 95% confidence interval (CI), 1.06-1.92; P = 0.019) and BRCA2 mutation carriers (HR, 2.21; 95% CI, 1.39-3.52, P = 0.0008). For BRCA1 mutation carriers, the breast cancer risk was higher in carriers with class II mutations than class I mutations (class II HR, 1.86; 95% CI, 1.28-2.70; class I HR, 0.86; 95%CI, 0.69-1.09; P-difference, 0.0006). Rs13306465 was associated with ovarian cancer risk in BRCA1 class II mutation carriers (HR, 2.42; P = 0.03).
Conclusion: The IRS1 Gly972Arg single-nucleotide polymorphism, which affects insulin-like growth factor and insulin signaling, modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers and breast cancer risk in BRCA1 class II mutation carriers.
Impact: These findings may prove useful for risk prediction for breast and ovarian cancers in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev; 21(8); 1362-70. (C)2012 AACR.
Filiaciones:
Ding, YC:
City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA 91010 USA
McGuffog, L:
Univ Cambridge Worts Causeway, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Cambridge, England
Healey, S:
Royal Brisbane Hosp, Queensland Inst Med Res, Genet & Populat Hlth Div, Brisbane, Qld 4029, Australia
Friedman, E:
Chaim Sheba Med Ctr, Oncogenet Unit, IL-52621 Tel Hashomer, Israel
Chaim Sheba Med Ctr, Inst Oncol, IL-52621 Tel Hashomer, Israel
Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel
Laitman, Y:
Chaim Sheba Med Ctr, Oncogenet Unit, IL-52621 Tel Hashomer, Israel
Chaim Sheba Med Ctr, Inst Oncol, IL-52621 Tel Hashomer, Israel
Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel
Shani-Paluch-Shimon:
Chaim Sheba Med Ctr, Oncogenet Unit, IL-52621 Tel Hashomer, Israel
Chaim Sheba Med Ctr, Inst Oncol, IL-52621 Tel Hashomer, Israel
Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel
Kaufman, B:
Chaim Sheba Med Ctr, Oncogenet Unit, IL-52621 Tel Hashomer, Israel
Chaim Sheba Med Ctr, Inst Oncol, IL-52621 Tel Hashomer, Israel
Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel
Liljegren, A:
Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden
Lindblom, A:
Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden
Olsson, H:
Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden
Kristoffersson, U:
Univ Lund Hosp, Dept Clin Genet, S-22185 Lund, Sweden
Stenmark-Askmalm, M:
Linkoping Univ, Dept Clin & Expt Med, Div Clin Genet, Linkoping, Sweden
Melin, B:
Umea Univ, Dept Radiat Sci, Umea, Sweden
Domchek, SM:
Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA
Nathanson, KL:
Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA
Rebbeck, TR:
Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA
Jakubowska, A:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Lubinski, J:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Jaworska, K:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Durda, K:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Gronwald, J:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Huzarski, T:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Cybulski, C:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Byrski, T:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Osorio, A:
Spanish Natl Canc Res Ctr, Human Canc Genet Programme, Human Genet Grp, Madrid, Spain
Spanish Natl Canc Res Ctr, Human Canc Genet Programme, Genotyping Unit, Madrid, Spain
Spanish Network Rare Dis CIBERER, Barcelona, Spain
Cajal, TR:
Hosp Santa Creu & Sant Pau, Oncol Serv, Barcelona, Spain
Stavropoulou, AV:
Natl Ctr Sci Res Demokritos, IRRP, Mol Diagnost Lab, Athens, Greece
Benitez, J:
Spanish Natl Canc Res Ctr, Human Canc Genet Programme, Human Genet Grp, Madrid, Spain
Spanish Natl Canc Res Ctr, Human Canc Genet Programme, Genotyping Unit, Madrid, Spain
Spanish Network Rare Dis CIBERER, Barcelona, Spain
Hamann, U:
Deutsch Krebsforschungszentrum DKFZ, Heidelberg, Germany
Rookus, M:
Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands
Aalfs, CM:
Univ Amsterdam, Acad Med Ctr, Dept Clin Genet, NL-1105 AZ Amsterdam, Netherlands
de Lange, JL:
Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands
Meijers-Heijboer, HEJ:
Vrije Univ Amsterdam Med Ctr, Dept Clin Genet, Amsterdam, Netherlands
Oosterwijk, JC:
Univ Groningen, Univ Med Ctr, Dept Genet, Groningen, Netherlands
van Asperen, CJ:
Leiden Univ, Med Ctr, Dept Clin Genet, Leiden, Netherlands
Garcia, EBG:
MUMC, Sch Oncol & Dev Biol, Dept Clin Genet, Maastricht, Netherlands
MUMC, Sch Oncol & Dev Biol, GROW, Maastricht, Netherlands
Hoogerbrugge, N:
Radboud Univ Nijmegen, Med Ctr, Hereditary Canc Clin, NL-6525 ED Nijmegen, Netherlands
Jager, A:
Erasmus Univ, Med Ctr, Family Canc Clin, Dept Med Oncol, Rotterdam, Netherlands
van der Luijt, RB:
Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands
Easton, DF:
Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England
Peock, S:
Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England
Frost, D:
Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England
Ellis, SD:
Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England
Platte, R:
Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England
Fineberg, E:
Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England
Evans, DG:
Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England
Lalloo, F:
Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England
Izatt, L:
Guys & St Thomas NHS Fdn Trust, London, England
Eeles, R:
Inst Canc Res, Oncogenet Team, London SW3 6JB, England
Royal Marsden NHS Fdn Trust, London, England
Adlard, J:
Yorkshire Reg Genet Serv, Leeds, W Yorkshire, England
Davidson, R:
Yorkhill Hosp, Ferguson Smith Ctr Clin Genet, Glasgow, Lanark, Scotland
Eccles, D:
Univ Hosp Southampton NHS Fdn Trust, Wessex Clin Genet Serv, Southampton, Hants, England
Cole, T:
Birmingham Womens Hosp Healthcare NHS Trust, W Midlands Reg Genet Serv, Birmingham, W Midlands, England
Cook, J:
Sheffield Childrens Hosp, Sheffield Clin Genet Serv, Sheffield, S Yorkshire, England
Brewer, C:
Royal Devon & Exeter Hosp, Dept Clin Genet, Exeter EX2 5DW, Devon, England
Tischkowitz, M:
Univ Cambridge, Dept Med Genet, Cambridge, England
Godwin, AK:
Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66103 USA
Pathak, H:
Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66103 USA
Stoppa-Lyonnet, D:
Inst Curie, Dept Tumour Biol, Paris, France
Inst Curie, Unite INSERM U830, Paris, France
Univ Paris 05, Fac Med, Paris, France
Sinilnikova, OM:
Univ Lyon 1, CNRS, UMR5286, Ctr Rech Cancerol Lyon,INSERM,U1052, F-69365 Lyon, France
Ctr Hosp Univ Lyon, Ctr Leon Berard, Unite Mixte Genet Constitut Canc Frequents, Lyon, France
Mazoyer, S:
Univ Lyon 1, CNRS, UMR5286, Ctr Rech Cancerol Lyon,INSERM,U1052, F-69365 Lyon, France
Barjhoux, L:
Univ Lyon 1, CNRS, UMR5286, Ctr Rech Cancerol Lyon,INSERM,U1052, F-69365 Lyon, France
Leone, M:
Ctr Hosp Univ Lyon, Ctr Leon Berard, Unite Mixte Genet Constitut Canc Frequents, Lyon, France
Gauthier-Villars, M:
Inst Curie, Dept Tumour Biol, Paris, France
Caux-Moncoutier, V:
Inst Curie, Dept Tumour Biol, Paris, France
de Pauw, A:
Inst Curie, Dept Tumour Biol, Paris, France
Hardouin, A:
Ctr Francois Baclesse, F-14021 Caen, France
Berthet, P:
Ctr Francois Baclesse, F-14021 Caen, France
Dreyfus, H:
CHU Grenoble, Dept Genet, F-38043 Grenoble, France
Univ Grenoble, Inst Albert Bonniot, Grenoble, France
Ferrer, SF:
Hotel Dieu Ctr Hosp, Lab Genet Chromosom, Chambery, France
Collonge-Rame, MA:
CHU Besancon, Serv Genet Biol Histol Biol Dev & Reprod, F-25030 Besancon, France
Sokolowska, J:
Nancy Univ, Ctr Hosp Reg & Univ, Med Genet Lab, Vandoeuvre Les Nancy, France
Buys, S:
Univ Utah, Huntsman Canc Inst, Dept Oncol Sci, Salt Lake City, UT USA
Daly, M:
Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
Miron, A:
Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA
Terry, MB:
Columbia Univ, Dept Epidemiol, New York, NY USA
Chung, W:
Columbia Univ, Dept Epidemiol, New York, NY USA
John, EM:
Canc Prevent Inst Calif, Fremont, CA USA
Stanford Univ, Sch Med, Palo Alto, CA 94304 USA
Stanford Canc Inst, Palo Alto, CA USA
Southey, M:
Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Melbourne, Vic 3010, Australia
Goldgar, D:
Univ Utah, Sch Med, Dept Dermatol, Salt Lake City, UT USA
Singer, CF:
Med Univ Vienna, Dept OB GYN, Vienna, Austria
Tea, MKM:
Med Univ Vienna, Dept OB GYN, Vienna, Austria
Gschwantler-Kaulich, D:
Med Univ Vienna, Dept OB GYN, Vienna, Austria
Fink-Retter, A:
Med Univ Vienna, Dept OB GYN, Vienna, Austria
Hansen, TVO:
Copenhagen Univ Hosp, Rigshosp, Ctr Genom Med, Copenhagen, Denmark
Ejlertsen, B:
Copenhagen Univ Hosp, Rigshosp, Dept Oncol, Copenhagen, Denmark
Johannsson, OT:
Landspitali Univ Hosp, Dept Oncol, Reykjavik, Iceland
Univ Iceland, Fac Med, Reykjavik, Iceland
Offit, K:
Clin Canc Genet Lab, Buffalo, NY USA
Sarrel, K:
Clin Canc Genet Lab, Buffalo, NY USA
Gaudet, MM:
Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA
Vijai, J:
Clin Canc Genet Lab, Buffalo, NY USA
Robson, M:
Mem Sloan Kettering Canc Ctr, Buffalo, NY USA
Piedmonte, MR:
Roswell Pk Canc Inst, Stat & Data Ctr, Gynecol Oncol Grp, Buffalo, NY 14263 USA
Andrews, L:
Australia New Zealand Gynaecol Oncol Grp, Camperdown, NSW, Australia
Cohn, D:
Ohio State Univ, Columbus Canc Council, Columbus, OH 43210 USA
DeMars, LR:
Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA
DiSilvestro, P:
Brown Univ, Women & Infants Hosp, Providence, RI USA
Rodriguez, G:
NorthShore Univ Hlth Syst, Evanston, IL USA
Toland, AE:
Ohio State Univ, Dept Internal Med, OSU Comprehens Canc Ctr, Div Human Canc Genet, Columbus, OH 43210 USA
Ohio State Univ, OSU Comprehens Canc Ctr, Dept Mol Virol Immunol & Med Genet, Div Human Canc Genet, Columbus, OH 43210 USA
Montagna, M:
Ist Oncol Veneto IOV IRCCS, Immunol & Mol Oncol Unit, Padua, Italy
Agata, S:
Ist Oncol Veneto IOV IRCCS, Immunol & Mol Oncol Unit, Padua, Italy
Imyanitov, E:
NN Petrov Oncol Res Inst, St Petersburg, Russia
Isaacs, C:
Georgetown Univ, Lombardi Comprehens Canc Ctr, Washington, DC USA
Janavicius, R:
Vilnius Univ Hosp, Santariskiu Clin, Hematol Oncol & Transfus Med Ctr, Dept Mol & Regenerat Med, Vilnius, Lithuania
Lazaro, C:
Inst Catala Oncol, Lab Recerca Translac, Hereditary Canc Program, Mol Diagnost Unit, Barcelona, Spain
Blanco, I:
IDIBELL Catalan Inst Oncol, Hereditary Canc Program, Genet Counseling Unit, Barcelona, Spain
Ramus, SJ:
Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA
Sucheston, L:
Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA
Karlan, BY:
Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, Los Angeles, CA 90048 USA
Gross, J:
Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, Los Angeles, CA 90048 USA
Ganz, PA:
Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Sch Med, Div Canc Prevent & Control Res, Los Angeles, CA 90024 USA
Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Sch Publ Hlth, Div Canc Prevent & Control Res, Los Angeles, CA 90024 USA
Beattie, MS:
Univ Calif San Francisco, Dept Med, San Francisco, CA USA
Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Biostat, San Francisco, CA 94143 USA
Schmutzler, RK:
Univ Hosp Cologne, Dept Obstet & Gynaecol, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Univ Hosp Cologne, CIO, Cologne, Germany
Wappenschmidt, B:
Univ Hosp Cologne, Dept Obstet & Gynaecol, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Univ Hosp Cologne, CIO, Cologne, Germany
Meindl, A:
Tech Univ Munich, Klinikum Rechts Isar, Div Tumor Genet, Dept Obstet & Gynaecol, D-8000 Munich, Germany
Arnold, N:
Univ Kiel, Univ Hosp Schleswig Holstein, Dept Obstet & Gynaecol, Kiel, Germany
Niederacher, D:
Univ Dusseldorf, Univ Hosp Dusseldorf, Dept Obstet & Gynaecol, D-40225 Dusseldorf, Germany
Preisler-Adams, S:
Univ Munster, Inst Human Genet, D-4400 Munster, Germany
Gadzicki, D:
Hannover Med Sch, Inst Cell & Mol Pathol, D-3000 Hannover, Germany
Varon-Mateeva, R:
Charite, Campus Virchov Klinikum, Inst Human Genet, Berlin, Germany
Deissler, H:
Univ Hosp Ulm, Dept Obstet & Gynaecol, Ulm, Germany
Gehrig, A:
Univ Wurzburg, Inst Human Genet, Dept Med Genet, Ctr Familial Breast & Ovarian Canc, D-8700 Wurzburg, Germany
Sutter, C:
Univ Heidelberg Hosp, Dept Human Genet, Inst Human Genet, Heidelberg, Germany
Kast, K:
Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Obstet & Gynaecol, D-01062 Dresden, Germany
Nevanlinna, H:
Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland
Univ Helsinki, Dept Clin Genet, Helsinki, Finland
Simard, J:
Ctr Hosp Univ Quebec, Canc Genom Lab, Canada Res Chair Oncogenet, Quebec City, PQ, Canada
Univ Laval, Quebec City, PQ, Canada
Spurdle, AB:
Royal Brisbane Hosp, Queensland Inst Med Res, Genet & Populat Hlth Div, Brisbane, Qld 4029, Australia
Beesley, J:
Royal Brisbane Hosp, Queensland Inst Med Res, Genet & Populat Hlth Div, Brisbane, Qld 4029, Australia
Chen, XQ:
Royal Brisbane Hosp, Queensland Inst Med Res, Genet & Populat Hlth Div, Brisbane, Qld 4029, Australia
Tomlinson, GE:
Univ Texas Hlth Sci Ctr San Antonio, Div Pediat Hematol Oncol, San Antonio, TX 78229 USA
Weitzel, J:
City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA 91010 USA
Garber, JE:
Harvard Univ, Sch Med, Dept Med, Boston, MA USA
Olopade, OI:
Univ Chicago, Dept Med, Chicago, IL 60637 USA
Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA
Rubinstein, WS:
Northshore Univ Healthsyst, Evanston, IL USA
Tung, N:
Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
Blum, JL:
Baylor Charles A Sammons Canc Ctr, Dallas, TX USA
Narod, SA:
Womens Coll Hosp, Toronto, ON M5S 1B2, Canada
Brummel, S:
Harvard Univ, Sch Publ Hlth, Ctr Biostat AIDS Res, Boston, MA 02115 USA
Gillen, DL:
Univ Calif Irvine, Dept Stat, Irvine, CA USA
Univ Calif Irvine, Dept Epidemiol, Irvine, CA USA
Lindor, N:
Mayo Clin, Dept Med Genet, Rochester, MN USA
Fredericksen, Z:
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Pankratz, VS:
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Couch, FJ:
Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
Radice, P:
Fdn IRCCS Ist Nazl Tumori INT, Dept Expt Oncol & Mol Med, Unit Genet Susceptibil Canc, Milan, Italy
Fdn Ist FIRC Oncol Mol, IFOM, Milan, Italy
Peterlongo, P:
Fdn IRCCS Ist Nazl Tumori INT, Dept Expt Oncol & Mol Med, Unit Genet Susceptibil Canc, Milan, Italy
Fdn Ist FIRC Oncol Mol, IFOM, Milan, Italy
Greene, MH:
NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, Rockville, MD USA
Loud, JT:
NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, Rockville, MD USA
Mai, PL:
NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, Rockville, MD USA
Andrulis, IL:
Univ Toronto, Dept Mol Genet, Toronto, ON, Canada
Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
Ozcelik, H:
Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
Thomassen, M:
Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark
Jensen, UB:
Skejby Hosp, Dept Clin Genet, Aarhus, Denmark
Skytte, AB:
Vejle Hosp, Dept Clin Genet, Vejle, Denmark
Caligo, MA:
Univ Pisa, Dept Lab Med, Sect Genet Oncol, Pisa, Italy
Univ Hosp Pisa, Pisa, Italy
Lee, A:
Univ Cambridge Worts Causeway, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Cambridge, England
Chenevix-Trench, G:
Royal Brisbane Hosp, Queensland Inst Med Res, Genet & Populat Hlth Div, Brisbane, Qld 4029, Australia
Antoniou, AC:
Univ Cambridge Worts Causeway, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Cambridge, England
Neuhausen, SL:
City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA 91010 USA
Univ Helsinki, Cent Hosp, Helsinki, Finland.
Green Accepted, Bronze
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