The EMT signaling pathways in endometrial carcinoma
Por:
Colas, E, Pedrola, N, Devis, L, Ertekin, T, Campoy, I, Martinez, E, Llaurado, M, Rigau, M, Olivan, M, Garcia, M, Cabrera, S, Gil-Moreno, A, Xercavins, J, Castellvi, J, Garcia, A, Cajal, SRY, Moreno-Bueno, G, Dolcet, X, Alameda, F, Palacios, J, Prat, J, Doll, A, Matias-Guiu, X, Abal, M, Reventos, J
Publicada:
1 oct 2012
Resumen:
Endometrial cancer (EC) is the most common gynecologic malignancy of the female genital tract and the fourth most common neoplasia in women. In EC, myometrial invasion is considered one of the most important prognostic factors. For this process to occur, epithelial tumor cells need to undergo an epithelial to mesenchymal transition (EMT), either transiently or stably, and to differing degrees. This process has been extensively described in other types of cancer but has been poorly studied in EC. In this review, several features of EMT and the main molecular pathways responsible for triggering this process are investigated in relation to EC. The most common hallmarks of EMT have been found in EC, either at the level of E-cadherin loss or at the induction of its repressors, as well as other molecular alterations consistent with the mesenchymal phenotype-like L1CAM and BMI-1 up-regulation. Pathways including progesterone receptor, TGF beta, ETV5 and microRNAs are deeply related to the EMT process in EC.
Filiaciones:
Colas, E:
Vall dHebron Res Inst, Biomed Res Unit, Barcelona, Spain
Univ Hosp, Barcelona, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Pedrola, N:
Vall dHebron Res Inst, Biomed Res Unit, Barcelona, Spain
Univ Hosp, Barcelona, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Devis, L:
Vall dHebron Res Inst, Biomed Res Unit, Barcelona, Spain
Univ Hosp, Barcelona, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Ertekin, T:
Vall dHebron Res Inst, Biomed Res Unit, Barcelona, Spain
Univ Hosp, Barcelona, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Campoy, I:
Vall dHebron Res Inst, Biomed Res Unit, Barcelona, Spain
Univ Hosp, Barcelona, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Martinez, E:
Vall dHebron Res Inst, Biomed Res Unit, Barcelona, Spain
Univ Hosp, Barcelona, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Llaurado, M:
Vall dHebron Res Inst, Biomed Res Unit, Barcelona, Spain
Univ Hosp, Barcelona, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Rigau, M:
Vall dHebron Res Inst, Biomed Res Unit, Barcelona, Spain
Univ Hosp, Barcelona, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Olivan, M:
Vall dHebron Res Inst, Biomed Res Unit, Barcelona, Spain
Univ Hosp, Barcelona, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Garcia, M:
Vall dHebron Res Inst, Biomed Res Unit, Barcelona, Spain
Univ Hosp, Barcelona, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Cabrera, S:
Hosp Valle De Hebron, Serv Ginecol, Barcelona, Spain
Gil-Moreno, A:
Hosp Valle De Hebron, Serv Ginecol, Barcelona, Spain
Xercavins, J:
Hosp Valle De Hebron, Serv Ginecol, Barcelona, Spain
Castellvi, J:
Hosp Valle De Hebron, Serv Patol, Barcelona, Spain
Garcia, A:
Hosp Valle De Hebron, Serv Patol, Barcelona, Spain
Cajal, SRY:
Hosp Valle De Hebron, Serv Patol, Barcelona, Spain
Moreno-Bueno, G:
IdiPAZ, Dept Bioquim IIB CSIC UAM, Madrid, Spain
Fdn MD Anderson Int, Madrid, Spain
Dolcet, X:
Hosp Arnau Vilanova, Serv Patol, Lleida, Spain
Alameda, F:
Hosp del Mar, Serv Patol, Barcelona, Spain
Palacios, J:
Hosp Virgen del Rocio, Serv Patol, Seville, Spain
Prat, J:
Hosp Santa Creu & Sant Pau, Serv Patol, Barcelona, Spain
Doll, A:
Vall dHebron Res Inst, Biomed Res Unit, Barcelona, Spain
Univ Hosp, Barcelona, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Matias-Guiu, X:
Hosp Arnau Vilanova, Serv Patol, Lleida, Spain
Abal, M:
Complejo Hosp Santiago de Compostela, Santiago De Compostela, Spain
Reventos, J:
Vall dHebron Res Inst, Biomed Res Unit, Barcelona, Spain
Univ Hosp, Barcelona, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Univ Int Catalunya, Dept Ciencies Basiques, Barcelona, Spain
Green Accepted
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