Identification of recent HIV-1 infection among newly diagnosed cases in Catalonia, Spain (2006-08)
Por:
Romero, A, Gonzalez, V, Esteve, A, Martro, E, Matas, L, Tural, C, Pumarola, T, Casanova, A, Ferrer, E, Caballero, E, Ribera, E, Margall, N, Domingo, P, Farre, J, Puig, T, Sauca, MG, Barrufet, P, Amengual, MJ, Navarro, G, Navarro, M, Vilaro, J, Ortin, X, Orti, A, Pujol, F, Prat, JM, Massabeu, A, Simo, JM, Villaverde, CA, Benitez, MA, Garcia, I, Diaz, O, Becerra, J, Ros, R, Sala, R, Rodrigo, I, Miro, JM, Casabona, J
Publicada:
1 dic 2012
Resumen:
Background: Quantification and description of patients recently infected by HIV can provide an accurate estimate of the dynamics of HIV transmission. Between 2006 and 2008 in Catalonia, we estimated the prevalence of recent HIV infection among newly diagnosed cases, described the epidemiological characteristics of the infection according to whether it was recent, long-standing or advanced, and identified factors associated with recent infection. Methods: A Test for Recent Infection (TRI) was performed in serum samples from patients newly diagnosed with HIV. Two different TRI were used: the Vironostika-LS assay (January 2006-May 2007) and the BED-CEIA CEIA (June 2007 onwards). Samples were obtained within the first 6 months of diagnosis. Patients whose samples tested positive in the TRI were considered recently infected. Results: Of 1125 newly diagnosed patients, 79.9% were men (median age, 35.4 years), 38.7% were born outside Spain, 48.9% were men who have sex with men (MSM) and 10.6% presented other sexually transmitted infections. The overall percentage of recent infection was 23.0%, which increased significantly, from 18.1% in 2006 to 26.2% in 2008. This percentage was higher for patients from South America (27.6%). Factors associated with recent infection were acquiring infection through sexual contact between MSM [odds ratio (OR) 2.0; 95% confidence interval (95% CI) 1.1-3.9], compared with acquiring infection through heterosexual relations and being under 30 years of age (OR 5.9; 95% CI 1.9-17.4), compared with being over 50 years of age. Conclusion: The highest percentage of recent infection was identified in MSM, suggesting either a higher incidence or a greater frequency of HIV testing. Information regarding testing patterns is necessary to correctly interpret data from recently infected individuals. Systems to monitor the HIV epidemic should include both parameters.
Filiaciones:
Romero, A:
IMIM Parc Salut Mar, Dept Epidemiol & Evaluat, Barcelona 08003, Spain
Ctr Estudis Epidemiol Infecc Transmissio Sexual &, Inst Catala Oncol, Dept Salut, Badalona, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Univ Autonoma Barcelona, Dept Paediat Obstet & Gynaecol & Prevent Med, Barcelona, Spain
Gonzalez, V:
Ctr Estudis Epidemiol Infecc Transmissio Sexual &, Inst Catala Oncol, Dept Salut, Badalona, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Dept Genet & Microbiol, Microbiol Serv, Badalona, Spain
Esteve, A:
Ctr Estudis Epidemiol Infecc Transmissio Sexual &, Inst Catala Oncol, Dept Salut, Badalona, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Martro, E:
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Dept Genet & Microbiol, Microbiol Serv, Badalona, Spain
Matas, L:
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Dept Genet & Microbiol, Microbiol Serv, Badalona, Spain
Pumarola, T:
Univ Barcelona, Hosp Clin CRESIB, Barcelona, Spain
Casanova, A:
Hosp Univ Bellvitge IDIBELL, Lhospitalet De Llobregat, Spain
Ferrer, E:
Hosp Univ Bellvitge IDIBELL, Lhospitalet De Llobregat, Spain
Caballero, E:
Univ Autonoma Barcelona, Hosp Univ Vall Hebron, E-08193 Barcelona, Spain
Ribera, E:
Univ Autonoma Barcelona, Hosp Univ Vall Hebron, E-08193 Barcelona, Spain
Margall, N:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Domingo, P:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Farre, J:
Hosp Arnau Vilanova, Lleida, Spain
Puig, T:
Hosp Arnau Vilanova, Lleida, Spain
Sauca, MG:
Hosp Mataro, Mataro, Spain
Barrufet, P:
Hosp Mataro, Mataro, Spain
Amengual, MJ:
Corporacio Sanitaria Parc Tauli, Sabadell, Spain
Navarro, G:
Univ Autonoma Barcelona, Dept Paediat Obstet & Gynaecol & Prevent Med, Barcelona, Spain
Corporacio Sanitaria Parc Tauli, Sabadell, Spain
Navarro, M:
Hosp Gen Vic, Vic, Spain
Vilaro, J:
Hosp Gen Vic, Vic, Spain
Ortin, X:
Hosp Verge Cinta, Tortosa, Spain
Orti, A:
Hosp Verge Cinta, Tortosa, Spain
Pujol, F:
Projecte Dels Noms Hispanosida, Barcelona, Spain
Prat, JM:
Hosp Palamos, Palamos, Spain
Massabeu, A:
Hosp Palamos, Palamos, Spain
Simo, JM:
Hosp Univ St Joan Reus, Reus, Spain
Villaverde, CA:
Hosp Univ St Joan Reus, Reus, Spain
Benitez, MA:
Hosp Vilafranca, Vilafranca Del Penedes, Spain
Garcia, I:
Hosp Gen LHospitalet, Lhospitalet De Llobregat, Spain
Diaz, O:
SAPS, Barcelona, Spain
Becerra, J:
ACASC, Barcelona, Spain
Sala, R:
Lab Sabater Tobella, Barcelona, Spain
Rodrigo, I:
Lab Clin Manso, Barcelona, Spain
Miro, JM:
Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain
Casabona, J:
Ctr Estudis Epidemiol Infecc Transmissio Sexual &, Inst Catala Oncol, Dept Salut, Badalona, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Univ Autonoma Barcelona, Dept Paediat Obstet & Gynaecol & Prevent Med, Barcelona, Spain
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