ICUD-EAU International Consultation on Bladder Cancer 2012: Urothelial Carcinoma of the Prostate
Por:
Palou, J, Wood, D, Bochner, BH, van der Poel, H, Al-Ahmadie, HA, Yossepowitch, O, Soloway, MS, Jenkins, LC
Publicada:
1 ene 2013
Resumen:
Context: The Second International Consultation on Bladder Cancer recommendations on urothelial carcinoma (UC) of the prostate were presented at the 2011 European Association of Urology Congress in Vienna, Austria, on March 18, 2011.
Objective: Our aim is to summarize the Second International Consultation on Bladder Cancer recommendations on UC of the prostate to help clinicians assess the current evidence-based management.
Evidence acquisition: The committee performed a thorough review of new data and updated previous recommendations. Levels of evidence and grades of recommendation were assigned based on a systematic review of the literature that included a search of online databases and review articles.
Evidence synthesis: Once a non-muscle-invasive high-grade tumor or carcinoma in situ (CIS) of the bladder has been diagnosed, careful follow-up of the prostatic urethra is necessary. Noninvasive UC including CIS of the prostate should be treated with intravesical bacillus Calmette-Guerin (BCG) following endoscopic resection. A transurethral resection of the prostate may improve contact of BCG with the prostatic urethra, and it appears that response rates to BCG are increased (level of evidence: 3). Transurethral biopsy of the prostatic urethra is effective in identifying prostatic involvement but may not accurately reveal the extent of involvement, particularly with stromal invasion. Stromal invasion by UC of the prostate carries a poor prognosis. Radical cystoprostatectomy is the treatment of choice for locoregional control in patients with prostatic stromal invasion.
Conclusions: These recommendations contain updated information on the diagnosis and treatment of UC of the prostate. However, prospective trials are needed to further elucidate the best management of these patients. (C) 2012 European Association of Urology. Published by Elsevier B. V. All rights reserved.
Filiaciones:
Palou, J:
Univ Autonoma Barcelona, Fundacio Puigvert, Dept Urol, Barcelona 08025, Spain
Wood, D:
Beaumont Hlth Syst, Dept Urol, Royal Oak, MI USA
Bochner, BH:
Mem Sloan Kettering Canc Ctr, Dept Urol, New York, NY 10021 USA
van der Poel, H:
Netherlands Canc Inst, Dept Urol, Amsterdam, Netherlands
Al-Ahmadie, HA:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
Yossepowitch, O:
Tel Aviv Univ, Inst Urol, Rabin Med Ctr, IL-69978 Tel Aviv, Israel
Soloway, MS:
Univ Miami, Miller Sch Med, Dept Urol, Miami, FL 33136 USA
Jenkins, LC:
Univ Miami, Miller Sch Med, Dept Urol, Miami, FL 33136 USA
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