GRADE guidelines: 11. Making an overall rating of confidence in effect estimates for a single outcome and for all outcomes


Por: Guyatt, G, Oxman, AD, Sultan, S, Brozek, J, Glasziou, P, Alonso-Coello, P, Atkins, D, Kunz, R, Montori, V, Jaeschke, R, Rind, D, Dahm, P, Akl, EA, Meerpohl, J, Vist, G, Berliner, E, Norris, S, Falck-Ytter, Y, Schunemann, HJ

Publicada: 1 feb 2013
Resumen:
GRADE requires guideline developers to make an overall rating of confidence in estimates of effect (quality of evidence high, moderate, low, or very low) for each important or critical outcome. GRADE suggests, for each outcome, the initial separate consideration of five domains of reasons for rating down the confidence in effect estimates, thereby allowing systematic review authors and guideline developers to arrive at an outcome-specific rating of confidence. Although this rating system represents discrete steps on an ordinal scale, it is helpful to view confidence in estimates as a continuum, and the final rating of confidence may differ from that suggested by separate consideration of each domain. An overall rating of confidence in estimates of effect is only relevant in settings when recommendations are being made. In general, it is based on the critical outcome that provides the lowest confidence. (C) 2013 Elsevier Inc. All rights reserved.

Filiaciones:
Guyatt, G:
 McMaster Univ, Dept Clin Epidemiol & Biostat, CLAR Res Grp, Hamilton, ON L8N 3Z5, Canada

 McMaster Univ, Dept Med, Hamilton, ON L8N 3Z5, Canada

Oxman, AD:
 Norwegian Knowledge Ctr Hlth Serv, N-0130 Oslo, Norway

Sultan, S:
 Univ Florida, Dept Med, Div Gastroenterol Hepatol & Nutr, Gainesville, FL USA

Brozek, J:
 Univ Oxford, Oxford, England

Glasziou, P:
 CIBERESP IIB St Pau, Iberoamer Cochrane Ctr, Barcelona 08041, Spain

Alonso-Coello, P:
 CIBERESP IIB St Pau, Iberoamer Cochrane Ctr, Barcelona 08041, Spain

Atkins, D:
 Univ Basel Hosp, Acad Swiss Insurance Med Asim, CH-4031 Basel, Switzerland

Kunz, R:
 Univ Basel Hosp, Basel Inst Clin Epidemiol, CH-4031 Basel, Switzerland

 Mayo Clin, Knowledge & Evaluat Res Unit, Rochester, MN USA

Montori, V:
 McMaster Univ, Dept Med, Hamilton, ON L8N 3Z5, Canada

Jaeschke, R:
 Harvard Univ, Sch Med, UpToDate, Boston, MA USA

Rind, D:
 Univ Florida, Dept Urol, Gainesville, FL USA

Dahm, P:
 SUNY Buffalo, Dept Med, Buffalo, NY 14260 USA

Akl, EA:
 Univ Med Ctr Freiburg, Inst Med Biometry & Med Informat, German Cochrane Ctr, D-79104 Freiburg, Germany

Meerpohl, J:
 Univ Med Ctr Freiburg, Dept Pediat & Adolescent Med, Div Pediat Hematol & Oncol, D-79106 Freiburg, Germany

 Agcy Healthcare Res & Qual, Ctr Outcomes & Evidence, Technol Assessment Program, Rockville, MD 20850 USA

Vist, G:
 Norwegian Knowledge Ctr Hlth Serv, N-0130 Oslo, Norway

Berliner, E:
 Oregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Portland, OR 97239 USA

Norris, S:
 Case Western Reserve Univ, Case & VA Med Ctr, Div Gastroenterol, Cleveland, OH 44106 USA

Falck-Ytter, Y:
 Case Western Reserve Univ, Case & VA Med Ctr, Div Gastroenterol, Cleveland, OH 44106 USA

Schunemann, HJ:
 McMaster Univ, Dept Med, Hamilton, ON L8N 3Z5, Canada

Dept Vet Affairs, Off Res & Dev, QUERI Program, Washington, DC USA
ISSN: 08954356





JOURNAL OF CLINICAL EPIDEMIOLOGY
Editorial
ELSEVIER SCIENCE INC, STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 66 Número: 2
Páginas: 151-157
WOS Id: 000313378500006
ID de PubMed: 22542023

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