16th IHIW: Extending the number of resources and bioinformatics analysis for the investigation of HLA rare alleles
Por:
Gonzalez-Galarza, FF, Mack, SJ, Hollenbach, J, Fernandez-Vina, M, Setterholm, M, Kempenich, J, Marsh, SGE, Jones, AR, Middleton, D, Vidal S., HLA Rare Allele Consortium
Publicada:
1 feb 2013
Resumen:
Continuing a project presented at the 15th International HLA and Immunogenetics Workshop (IHIWS) on the rarity of HLA alleles, we sought to expand the number of data sources and bioinformatics tools available in the Allele Frequencies Net Database website (AFND, www.allelefrequencies.net). In this 16th IHIWS Rare Alleles project, HLA alleles described in the latest IMGT/HLA Database (release 3.8.0) were queried against different sources including data from registries (stem cell) and from 74 different laboratories around the world. We demonstrated that approximately 40% of the alleles officially named in the IMGT/HLA Database have been reported only once across all different sources. To facilitate the large-scale analysis of rare alleles, we have produced an online tool called the Rare Allele Detector that simplifies the detection of alleles that are considered to be very rare, rare or frequent. Tools and associated data can be accessed via the www.allelefrequencies.net website.
Filiaciones:
Gonzalez-Galarza, FF:
Univ Liverpool, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England
Mack, SJ:
Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA
Hollenbach, J:
Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA
Fernandez-Vina, M:
Stanford Univ, Dept Pathol, Stanford, CA 94305 USA
Setterholm, M:
Natl Marrow Donor Program, Minneapolis, MN USA
Kempenich, J:
Natl Marrow Donor Program, Minneapolis, MN USA
Marsh, SGE:
Anthony Nolan Res Inst, London, England
UCL Canc Inst, London, England
Jones, AR:
Univ Liverpool, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England
Middleton, D:
Royal Liverpool & Broad Green Univ Trust, Liverpool, Merseyside, England
Vidal S.:
Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain
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