Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk
Por:
Couch, FJ, Wang, XS, McGuffog, L, Lee, A, Olswold, C, Kuchenbaecker, KB, Soucy, P, Fredericksen, Z, Barrowdale, D, Dennis, J, Gaudet, MM, Dicks, E, Kosel, M, Healey, S, Sinilnikova, OM, Lee, A, Bacot, F, Vincent, D, Hogervorst, FBL, Peock, S, Stoppa-Lyonnet, D, Jakubowska, A, Radice, P, Schmutzler, RK, Domchek, SM, Piedmonte, M, Singer, CF, Friedman, E, Thomassen, M, Hansen, TVO, Neuhausen, SL, Szabo, CI, Blanco, I, Greene, MH, Karlan, BY, Garber, J, Phelan, CM, Weitzel, JN, Montagna, M, Olah, E, Andrulis, IL, Godwin, AK, Yannoukakos, D, Goldgar, DE, Caldes, T, Nevanlinna, H, Osorio, A, Terry, MB, Daly, MB, van Rensburg, EJ, Hamann, U, Ramus, SJ, Toland, AE, Caligo, MA, Olopade, OI, Tung, N, Claes, K, Beattie, MS, Southey, MC, Imyanitov, EN, Tischkowitz, M, Janavicius, R, John, EM, Kwong, A, Diez, O, Balmana, J, Barkardottir, RB, Arun, BK, Rennert, G, Teo, SH, Ganz, PA, Campbell, I, van der Hout, AH, van Deurzen, CHM, Seynaeve, C, Garcia, EBG, van Leeuwen, FE, Meijers-Heijboer, HEJ, Gille, JJP, Ausems, MGEM, Blok, MJ, Ligtenberg, MJL, Rookus, MA, Devilee, P, Verhoef, S, van Os, TAM, Wijnen, JT, Frost, D, Ellis, S, Fineberg, E, Platte, R, Evans, DG, Izatt, L, Eeles, RA, Adlard, J, Eccles, DM, Cook, J, Brewer, C, Douglas, F, Hodgson, S, Morrison, PJ, Side, LE, Donaldson, A, Houghton, C, Rogers, MT, Dorkins, H, Eason, J, Gregory, H, McCann, E, Murray, A, Calender, A, Hardouin, A, Berthet, P, Delnatte, C, Nogues, C, Lasset, C, Houdayer, C, Leroux, D, Rouleau, E, Prieur, F, Damiola, F, Sobol, H, Coupier, I, Venat-Bouvet, L, Castera, L, Gauthier-Villars, M, Leone, M, Pujol, P, Mazoyer, S, Bignon, YJ, Zlowocka-Perlowska, E, Gronwald, J, Lubinski, J, Durda, K, Jaworska, K, Huzarski, T, Spurdle, AB, Viel, A, Peissel, B, Bonanni, B, Melloni, G, Ottini, L, Papi, L, Varesco, L, Tibiletti, MG, Peterlongo, P, Volorio, S, Manoukian, S, Pensotti, V, Arnold, N, Engel, C, Deissler, H, Gadzicki, D, Gehrig, A, Kast, K, Rhiem, K, Meindl, A, Niederacher, D, Ditsch, N, Plendl, H, Preisler-Adams, S, Engert, S, Sutter, C, Varon-Mateeva, R, Wappenschmidt, B, Weber, BHF, Arver, B, Stenmark-Askmalm, M, Loman, N, Rosenquist, R, Einbeigi, Z, Nathanson, KL, Rebbeck, TR, Blank, SV, Cohn, DE, Rodriguez, GC, Small, L, Friedlander, M, Bae-Jump, VL, Fink-Retter, A, Rappaport, C, Gschwantler-Kaulich, D, Pfeiler, G, Tea, MK, Lindor, NM, Kaufman, B, Paluch, SS, Laitman, Y, Skytte, AB, Gerdes, AM, Pedersen, IS, Moeller, ST, Kruse, TA, Jensen, UB, Vijai, J, Sarrel, K, Robson, M, Kauff, N, Mulligan, AM, Glendon, G, Ozcelik, H, Ejlertsen, B, Nielsen, FC, Jonson, L, Andersen, MK, Ding, YC, Steele, L, Foretova, L, Teule, A, Lazaro, C, Brunet, J, Pujana, MA, Mai, PL, Loud, JT, Walsh, C, Lester, J, Orsulic, S, Narod, SA, Herzog, J, Sand, SR, Tognazzo, S, Agata, S, Vaszko, T, Weaver, J, Stavropoulou, AV, Buys, SS, Romero, A, de la Hoya, M, Aittomaki, K, Muranen, TA, Duran, M, Chung, WK, Lasa, A, Dorfling, CM, Miron, A, Benitez, J, Senter, L, Huo, DZ, Chan, SB, Sokolenko, AP, Chiquette, J, Tihomirova, L, Friebel, TM, Agnarsson, BA, Lu, KH, Lejbkowicz, F, James, PA, Hall, P, Dunning, AM, Tessier, D, Cunningham, J, Slager, SL, Wang, C, Hart, S, Stevens, K, Simard, J, Pastinen, T, Pankratz, VS, Offit, K, Easton, DF, Chenevix-Trench, G, Antoniou, AC
Publicada:
1 mar 2013
Resumen:
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7 x 10(-8), HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4 x 10(-8), HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4 x 10(-8), HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific association. The 17q21.31 locus was also associated with ovarian cancer risk in 8,211 BRCA2 carriers (P = 2 x 10(-4)). These loci may lead to an improved understanding of the etiology of breast and ovarian tumors in BRCA1 carriers. Based on the joint distribution of the known BRCA1 breast cancer risk-modifying loci, we estimated that the breast cancer lifetime risks for the 5% of BRCA1 carriers at lowest risk are 28%-50% compared to 81%-100% for the 5% at highest risk. Similarly, based on the known ovarian cancer risk-modifying loci, the 5% of BRCA1 carriers at lowest risk have an estimated lifetime risk of developing ovarian cancer of 28% or lower, whereas the 5% at highest risk will have a risk of 63% or higher. Such differences in risk may have important implications for risk prediction and clinical management for BRCA1 carriers.
Filiaciones:
Couch, FJ:
Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
Mayo Clin, Rochester, MN USA
Wang, XS:
Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
McGuffog, L:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Lee, A:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Mayo Clin, Dept Mol Pharmacol & Expt Therapeut MPET, Rochester, MN USA
Olswold, C:
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Kuchenbaecker, KB:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Soucy, P:
Ctr Hosp Univ Quebec, Canc Genom Lab, Quebec City, PQ, Canada
Univ Laval, Quebec City, PQ, Canada
Fredericksen, Z:
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Barrowdale, D:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Dennis, J:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Gaudet, MM:
Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA
Dicks, E:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Kosel, M:
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Healey, S:
Queensland Inst Med Res, Dept Genet, Brisbane, Qld 4006, Australia
Sinilnikova, OM:
Hosp Civils Lyon, Unite Mixte Genet Constitut Canc Frequents, Ctr Leon Berard, Lyon, France
Univ Lyon 1, INSERM U1052, CNRS UMR5286, Ctr Rech Cancerol Lyon, F-69365 Lyon, France
Lee, A:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Mayo Clin, Dept Mol Pharmacol & Expt Therapeut MPET, Rochester, MN USA
Bacot, F:
Ctr Innovat Genome Quebec, Montreal, PQ, Canada
McGill Univ, Montreal, PQ, Canada
Vincent, D:
Ctr Innovat Genome Quebec, Montreal, PQ, Canada
McGill Univ, Montreal, PQ, Canada
Hogervorst, FBL:
Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands
Peock, S:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Stoppa-Lyonnet, D:
Inst Curie, Dept Tumour Biol, Paris, France
Inst Curie, INSERM U830, Paris, France
Univ Paris 05, Sorbonne Paris Cite, Paris, France
Jakubowska, A:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Radice, P:
Fdn IRCCS Ist Nazl Tumori INT, Unit Mol Bases Genet Risk & Genet Testing, Dept Prevent & Predict Med, Milan, Italy
Fdn Ist FIRC Oncol Mol, IFOM, Milan, Italy
Schmutzler, RK:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Dept Obstet & Gynaecol, Cologne, Germany
Univ Hosp Cologne, Ctr Integrated Oncol, Ctr Mol Med Cologne, Cologne, Germany
Domchek, SM:
Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA
Piedmonte, M:
Roswell Pk Canc Inst, Gynecol Oncol Grp, Stat & Data Ctr, Buffalo, NY 14263 USA
Singer, CF:
Med Univ Vienna, Dept Obstet & Gynecol, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Friedman, E:
Chaim Sheba Med Ctr, Tel Aviv, Israel
Thomassen, M:
Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark
Hansen, TVO:
Copenhagen Univ Hosp, Ctr Genom Med, Rigshosp, Copenhagen, Denmark
Neuhausen, SL:
City Hope Natl Med Ctr, Dept Populat Sci, Beckman Res Inst, Duarte, CA USA
Szabo, CI:
Univ Delaware, Ctr Translat Canc Res, Dept Biol Sci, Newark, DE USA
Blanco, I:
IDIBELL Catalan Inst Oncol, Genet Counseling Unit, Hereditary Canc Program, Barcelona, Spain
Greene, MH:
NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA
Karlan, BY:
Cedars Sinai Med Ctr, Womens Canc Program, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA
Garber, J:
Dana Farber Canc Inst, Boston, MA 02115 USA
Phelan, CM:
Univ S Florida, H Lee Moffitt Canc Ctr, Dept Canc Epidemiol, Tampa, FL 33682 USA
Weitzel, JN:
City Hope Natl Med Ctr, Clin Canc Genet, City Hope Clin Canc Genet Community Res Network, Duarte, CA USA
Montagna, M:
Ist Oncol Veneto IOV IRCCS, Immunol & Mol Oncol Unit, Padua, Italy
Olah, E:
Natl Inst Oncol, Dept Mol Genet, Budapest, Hungary
Andrulis, IL:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Godwin, AK:
Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66103 USA
Yannoukakos, D:
Natl Ctr Sci Res Demokritos, Mol Diagnost Lab, IRRP, Athens, Greece
Goldgar, DE:
Univ Utah, Sch Med, Dept Dermatol, Salt Lake City, UT USA
Caldes, T:
Hosp Clin San Carlos, IdISSC, Mol Oncol Lab, Madrid, Spain
Nevanlinna, H:
Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland
Univ Helsinki, Cent Hosp, Helsinki, Finland
Osorio, A:
Spanish Natl Canc Ctr CNIO, Human Genet Grp, Madrid, Spain
Biomed Network Rare Dis CIBERER, Madrid, Spain
Terry, MB:
Columbia Univ, Dept Epidemiol, New York, NY USA
Daly, MB:
Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
Hamann, U:
Deutsch Krebsforschungszentrum DKFZ, Heidelberg, Germany
Ramus, SJ:
Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA
Toland, AE:
Ohio State Univ, Dept Internal Med & Mol Virol, Div Human Canc Genet, Ctr Comprehens Canc, Columbus, OH 43210 USA
Ohio State Univ, Ctr Comprehens Canc, Div Human Canc Genet, Dept Immunol, Columbus, OH 43210 USA
Ohio State Univ, Ctr Comprehens Canc, Div Human Canc Genet, Dept Med Genet, Columbus, OH 43210 USA
Caligo, MA:
Univ Pisa, Sect Genet Oncol, Dept Lab Med, Pisa, Italy
Univ Hosp Pisa, Pisa, Italy
Olopade, OI:
Univ Chicago, Med Ctr, Ctr Clin Canc Genet & Global Hlth, Chicago, IL 60637 USA
Tung, N:
Beth Israel Deaconess Med Ctr, Dept Med Oncol, Boston, MA 02215 USA
Claes, K:
Ghent Univ Hosp, Ctr Med Genet, Ghent, Belgium
Beattie, MS:
Univ Calif San Francisco, Dept Med, San Francisco, CA USA
Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Biostat, San Francisco, CA 94143 USA
Southey, MC:
Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Parkville, Vic 3052, Australia
Imyanitov, EN:
NN Petrov Oncol Res Inst, St Petersburg, Russia
Tischkowitz, M:
McGill Univ, Program Canc Genet, Dept Human Genet, Montreal, PQ, Canada
McGill Univ, Dept Oncol, Program Canc Genet, Montreal, PQ, Canada
Janavicius, R:
Vilnius Univ Hosp Santariskiu Clin, Hematol Oncol & Transfus Med Ctr, Dept Mol & Regenerat Med, Vilnius, Lithuania
John, EM:
Canc Prevent Inst Calif, Dept Epidemiol, Fremont, CA USA
Kwong, A:
Hong Kong Sanat & Hosp, Hong Kong Hereditary Breast Canc Family Registry, Canc Genet Ctr, Hong Kong, Hong Kong, Peoples R China
Diez, O:
Univ Hosp Vall dHebron, Oncogenet Lab, Barcelona, Spain
Vall dHebron Inst Oncol VHIO, Barcelona, Spain
Balmana, J:
Univ Hosp, Dept Med Oncol, Barcelona, Spain
Barkardottir, RB:
Landspitali Univ Hosp, Dept Pathol, Reykjavik, Iceland
Univ Iceland, Fac Med, BMC, Reykjavik, Iceland
Arun, BK:
Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol & Clin Canc Genet, Houston, TX 77030 USA
Rennert, G:
Clalit Natl Israeli Canc Control Ctr, Haifa, Israel
Carmel Hosp, Dept Community Med & Epidemiol, Haifa, Israel
B Rappaport Fac Med, Haifa, Israel
Teo, SH:
Univ Malaya, Canc Res Initiat Fdn, Sime Darby Med Ctr, Kuala Lumpur, Malaysia
Univ Malaya, Canc Res Inst, Kuala Lumpur, Malaysia
Ganz, PA:
Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Sch Med, Div Canc Prevent & Control Res, Los Angeles, CA 90024 USA
Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Sch Publ Hlth, Div Canc Prevent & Control Res, Los Angeles, CA 90024 USA
Campbell, I:
Peter MacCallum Canc Ctr, VBCRC Canc Genet Lab, Melbourne, Vic, Australia
van der Hout, AH:
Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands
van Deurzen, CHM:
Erasmus Univ, Dept Pathol, Family Canc Clin, Med Ctr, NL-3000 DR Rotterdam, Netherlands
Seynaeve, C:
Erasmus Univ, Dept Med Oncol, Family Canc Clin, Med Ctr, Rotterdam, Netherlands
Garcia, EBG:
MUMC, Dept Clin Genet, Sch Oncol & Dev Biol, Maastricht, Netherlands
MUMC, GROW, Sch Oncol & Dev Biol, Maastricht, Netherlands
van Leeuwen, FE:
Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands
Meijers-Heijboer, HEJ:
Vrije Univ Amsterdam Med Ctr, Dept Clin Genet, Amsterdam, Netherlands
Gille, JJP:
Vrije Univ Amsterdam Med Ctr, Dept Clin Genet, Amsterdam, Netherlands
Ausems, MGEM:
Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands
Blok, MJ:
Maastricht Univ Med Ctr, Dept Clin Genet, Maastricht, Netherlands
Ligtenberg, MJL:
Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, NL-6525 ED Nijmegen, Netherlands
Radboud Univ Nijmegen, Dept Pathol, Med Ctr, NL-6525 ED Nijmegen, Netherlands
Rookus, MA:
Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands
Devilee, P:
Leiden Univ, Dept Human Genet, Med Ctr, NL-2300 RA Leiden, Netherlands
Leiden Univ, Dept Pathol, Med Ctr, Leiden, Netherlands
Verhoef, S:
Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands
van Os, TAM:
Univ Amsterdam, Acad Med Ctr, Dept Clin Genet, NL-1105 AZ Amsterdam, Netherlands
Wijnen, JT:
Leiden Univ, Dept Human Genet, Med Ctr, NL-2300 RA Leiden, Netherlands
Leiden Univ, Dept Clin Genet, Med Ctr, Leiden, Netherlands
Frost, D:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Fineberg, E:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Platte, R:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Evans, DG:
Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England
Izatt, L:
Guys & St Thomas NHS Fdn Trust, London, England
Eeles, RA:
Inst Canc Res, Oncogenet Team, London SW3 6JB, England
Royal Marsden NHS Fdn Trust, London, England
Adlard, J:
Yorkshire Reg Genet Serv, Leeds, W Yorkshire, England
Eccles, DM:
Univ Southampton, Fac Med, Southampton Univ Hosp NHS Trust, Southampton SO9 5NH, Hants, England
Cook, J:
Sheffield Childrens Hosp, Sheffield Clin Genet Serv, Sheffield, S Yorkshire, England
Brewer, C:
Royal Devon & Exeter Hosp, Dept Clin Genet, Exeter EX2 5DW, Devon, England
Douglas, F:
Newcastle Upon Tyne Hosp NHS Trust, Inst Med Genet, Ctr Life, Newcastle Upon Tyne, Tyne & Wear, England
Hodgson, S:
St Georges Univ London, Dept Clin Genet, London, England
Morrison, PJ:
Belfast Hlth & Social Care Trust, Northern Ireland Reg Genet Ctr, Belfast, Antrim, North Ireland
Queens Univ Belfast, Dept Med Genet, Belfast, Antrim, North Ireland
Side, LE:
Great Ormond St Hosp Sick Children, North East Thames Reg Genet Serv, London WC1N 3JH, England
UCL, Inst Womens Hlth, London, England
Donaldson, A:
St Michaels Hosp, Dept Clin Genet, Bristol, Avon, England
Houghton, C:
Liverpool Womens NHS Fdn Trust, Cheshire & Merseyside Clin Genet Serv, Liverpool, Merseyside, England
Rogers, MT:
Univ Wales Hosp, All Wales Med Genet Serv, Cardiff CF4 4XW, S Glam, Wales
Dorkins, H:
Kennedy Galton Ctr, North West Thames Reg Genet Serv, Harrow, Middx, England
Eason, J:
Nottingham Univ Hosp NHS Trust, Nottingham Clin Genet Serv, Nottingham, England
Gregory, H:
NHS Grampian, North Scotland Reg Genet Serv, Aberdeen, Scotland
Univ Aberdeen, Aberdeen, Scotland
Murray, A:
Singleton Hosp, All Wales Med Genet Serv, Swansea SA2 8QA, W Glam, Wales
Calender, A:
Hosp Civils Lyon, Unite Mixte Genet Constitut Canc Frequents, Ctr Leon Berard, Lyon, France
Hardouin, A:
Ctr Francois Baclesse, F-14021 Caen, France
Berthet, P:
Ctr Francois Baclesse, F-14021 Caen, France
Delnatte, C:
Ctr Rene Gauducheau, F-44035 Nantes, France
Nogues, C:
Hop Rene Huguenin, Oncogenet Clin, Inst Curie, St Cloud, France
Lasset, C:
Ctr Leon Berard, Unite Prevent & Epidemiol Genet, F-69373 Lyon, France
Univ Lyon 1, CNRS UMR5558, F-69365 Lyon, France
Houdayer, C:
Inst Curie, Dept Tumour Biol, Paris, France
Univ Paris 05, Sorbonne Paris Cite, Paris, France
Leroux, D:
CHU Grenoble, Dept Genet, F-38043 Grenoble, France
Univ Grenoble, Inst Albert Bonniot, Grenoble, France
Rouleau, E:
Hop Rene Huguenin, Lab Oncogenet, Inst Curie, St Cloud, France
Prieur, F:
Ctr Hosp Univ St Etienne, Serv Genet Clin Chromosom & Mol, St Etienne, France
Damiola, F:
Univ Lyon 1, INSERM U1052, CNRS UMR5286, Ctr Rech Cancerol Lyon, F-69365 Lyon, France
Sobol, H:
Univ Aix Marseille 2, Dept Oncol Genet Prevent & Depistage, INSERM CIC P9502, Inst Paoli Calmettes, F-13284 Marseille 07, France
Coupier, I:
CHU Arnaud de Villeneuve, Unite Oncogenet, Montpellier, France
CRLCC Val dAurelle, Unite Oncogenet, Montpellier, France
Venat-Bouvet, L:
Ctr Hosp Univ Dupuytren, Dept Med Oncol, Limoges, France
Castera, L:
Inst Curie, Dept Tumour Biol, Paris, France
Gauthier-Villars, M:
Inst Curie, Dept Tumour Biol, Paris, France
Leone, M:
Hosp Civils Lyon, Unite Mixte Genet Constitut Canc Frequents, Ctr Leon Berard, Lyon, France
Pujol, P:
CHU Arnaud de Villeneuve, Unite Oncogenet, Montpellier, France
CRCM Val dAurelle, INSERM 896, Montpellier, France
Mazoyer, S:
Univ Lyon 1, INSERM U1052, CNRS UMR5286, Ctr Rech Cancerol Lyon, F-69365 Lyon, France
Bignon, YJ:
Univ Clermont Ferrand 2, Dept Oncogenet, Ctr Jean Perrin, Clermont Ferrand, France
Zlowocka-Perlowska, E:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Gronwald, J:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Lubinski, J:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Durda, K:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Jaworska, K:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Warsaw Med Univ, Postgrad Sch Mol Med, Warsaw, Poland
Huzarski, T:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Spurdle, AB:
Queensland Inst Med Res, Dept Genet, Brisbane, Qld 4006, Australia
Viel, A:
IRCCS, Div Expt Oncol 1, Ctr Riferimento Oncologico, Aviano, Italy
Peissel, B:
Fdn IRCCS Ist Nazl Tumori INT, Unit Med Genet, Dept Prevent & Predict Med, Milan, Italy
Bonanni, B:
Ist Europeo Oncol, Div Canc Prevent & Genet, Milan, Italy
Melloni, G:
Fdn IRCCS Ist Nazl Tumori INT, Unit Med Genet, Dept Prevent & Predict Med, Milan, Italy
Ottini, L:
Univ Roma La Sapienza, Dept Mol Med, Rome, Italy
Papi, L:
Univ Florence, Unit Med Genet, Dept Clin Physiopathol, Florence, Italy
Varesco, L:
IRCCS AOU San Martino IST Ist Nazl Ric Canc, Unit Hereditary Canc, Dept Epidemiol Prevent & Special Funct, Genoa, Italy
Tibiletti, MG:
Osped Circolo Univ Insubria, UO Anat Patol, Varese, Italy
Peterlongo, P:
Fdn IRCCS Ist Nazl Tumori INT, Unit Mol Bases Genet Risk & Genet Testing, Dept Prevent & Predict Med, Milan, Italy
Fdn Ist FIRC Oncol Mol, IFOM, Milan, Italy
Volorio, S:
Fdn Ist FIRC Oncol Mol, IFOM, Milan, Italy
Cogentech Canc Genet Test Lab, Milan, Italy
Manoukian, S:
Fdn IRCCS Ist Nazl Tumori INT, Unit Med Genet, Dept Prevent & Predict Med, Milan, Italy
Pensotti, V:
Fdn Ist FIRC Oncol Mol, IFOM, Milan, Italy
Cogentech Canc Genet Test Lab, Milan, Italy
Arnold, N:
Univ Kiel, Univ Hosp Schleswig Holstein, Kiel, Germany
Engel, C:
Univ Leipzig, Inst Med Informat Stat & Epidemiol, D-04109 Leipzig, Germany
Deissler, H:
Univ Hosp Ulm, Ulm, Germany
Gadzicki, D:
Hannover Med Sch, Hannover, Germany
Gehrig, A:
Univ Wurzburg, Inst Human Genet, Wurzburg, Germany
Kast, K:
Tech Univ Dresden, Dept Obstet & Gynaecol, Univ Hosp Carl Gustav Carus, D-01062 Dresden, Germany
Rhiem, K:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Dept Obstet & Gynaecol, Cologne, Germany
Univ Hosp Cologne, Ctr Integrated Oncol, Ctr Mol Med Cologne, Cologne, Germany
Meindl, A:
Tech Univ Munich, Klinikum Rechts Isar, Dept Obstet & Gynaecol, Div Tumor Genet, D-80290 Munich, Germany
Niederacher, D:
Univ Dusseldorf, Dept Obstet & Gynaecol, Univ Med Ctr Dusseldorf, D-40225 Dusseldorf, Germany
Ditsch, N:
Univ Munich, Dept Obstet & Gynaecol, Munich, Germany
Plendl, H:
Univ Kiel, Univ Hosp Schleswig Holstein, Inst Human Genet, Kiel, Germany
Preisler-Adams, S:
Univ Munster, Inst Human Genet, D-48149 Munster, Germany
Engert, S:
Tech Univ Munich, Klinikum Rechts Isar, Dept Obstet & Gynaecol, Div Tumor Genet, D-80290 Munich, Germany
Sutter, C:
Heidelberg Univ, Inst Human Genet, Heidelberg, Germany
Varon-Mateeva, R:
Inst Med & Human Genet, Berlin, Germany
Wappenschmidt, B:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Dept Obstet & Gynaecol, Cologne, Germany
Univ Hosp Cologne, Ctr Integrated Oncol, Ctr Mol Med Cologne, Cologne, Germany
Weber, BHF:
Univ Regensburg, Inst Human Genet, D-93053 Regensburg, Germany
Arver, B:
Karolinska Univ Hosp, Dept Pathol & Oncol, Stockholm, Sweden
Stenmark-Askmalm, M:
Linkoping Univ, Div Clin Genet, Dept Clin & Expt Med, Linkoping, Sweden
Loman, N:
Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden
Rosenquist, R:
Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Uppsala, Sweden
Einbeigi, Z:
Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden
Nathanson, KL:
Univ Penn, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA
Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA
Rebbeck, TR:
Univ Penn, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA
Univ Penn, Ctr Clin Epidemiol & Biostat, Perelman Sch Med, Philadelphia, PA 19104 USA
Blank, SV:
NYU, Sch Med, NYU Womens Canc Program, New York, NY USA
Cohn, DE:
Ohio State Univ, Columbus Canc Council, Columbus, OH 43210 USA
Rodriguez, GC:
Univ Chicago, North Shore Univ Hlth Syst, Div Gynecol Oncol, Evanston, IL USA
Small, L:
Maine Womens Surg & Canc Ctr, Maine Med Ctr, Scarborough, ME USA
Friedlander, M:
Australia New Zealand GOG, ANZ GOTG Coordinating Ctr, Camperdown, NSW, Australia
Bae-Jump, VL:
Univ N Carolina, Chapel Hill, NC USA
Fink-Retter, A:
Med Univ Vienna, Dept Obstet & Gynecol, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Rappaport, C:
Med Univ Vienna, Dept Obstet & Gynecol, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Gschwantler-Kaulich, D:
Med Univ Vienna, Dept Obstet & Gynecol, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Pfeiler, G:
Med Univ Vienna, Dept Obstet & Gynecol, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Tea, MK:
Med Univ Vienna, Dept Obstet & Gynecol, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Lindor, NM:
Mayo Clin Arizona, Dept Hlth Sci Res, Scottsdale, AZ USA
Kaufman, B:
Chaim Sheba Med Ctr, Tel Aviv, Israel
Paluch, SS:
Chaim Sheba Med Ctr, Tel Aviv, Israel
Laitman, Y:
Chaim Sheba Med Ctr, Tel Aviv, Israel
Skytte, AB:
Vejle Hosp, Dept Clin Genet, Vejle, Denmark
Gerdes, AM:
Rigshosp, Dept Clincial Genet, Copenhagen, Denmark
Pedersen, IS:
Aalborg Univ Hosp, Sect Mol Diagnost, Dept Clin Biochem, Aalborg, Denmark
Moeller, ST:
Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark
Kruse, TA:
Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark
Jensen, UB:
Aarhus Univ Hosp, Dept Clin Genet, DK-8000 Aarhus, Denmark
Vijai, J:
Mem Sloan Kettering Canc Ctr, Clin Genet Serv, New York, NY 10021 USA
Sarrel, K:
Mem Sloan Kettering Canc Ctr, Clin Genet Serv, New York, NY 10021 USA
Robson, M:
Mem Sloan Kettering Canc Ctr, Clin Genet Serv, New York, NY 10021 USA
Kauff, N:
Mem Sloan Kettering Canc Ctr, Clin Genet Serv, New York, NY 10021 USA
Mulligan, AM:
Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
St Michaels Hosp, Dept Lab Med, Toronto, ON M5B 1W8, Canada
St Michaels Hosp, Keenan Res Ctr, Li Ka Shing Knowledge Inst, Toronto, ON M5B 1W8, Canada
Glendon, G:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Ozcelik, H:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
Ejlertsen, B:
Copenhagen Univ Hosp, Dept Oncol, Rigshosp, Copenhagen, Denmark
Nielsen, FC:
Copenhagen Univ Hosp, Ctr Genom Med, Rigshosp, Copenhagen, Denmark
Jonson, L:
Copenhagen Univ Hosp, Ctr Genom Med, Rigshosp, Copenhagen, Denmark
Andersen, MK:
Copenhagen Univ Hosp, Dept Clin Genet, Rigshosp, Copenhagen, Denmark
Ding, YC:
City Hope Natl Med Ctr, Dept Populat Sci, Beckman Res Inst, Duarte, CA USA
Steele, L:
City Hope Natl Med Ctr, Dept Populat Sci, Beckman Res Inst, Duarte, CA USA
Foretova, L:
Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic
Teule, A:
IDIBELL Catalan Inst Oncol, Genet Counseling Unit, Hereditary Canc Program, Barcelona, Spain
Lazaro, C:
IDIBELL Catalan Inst Oncol, Mol Diagnost Unit, Hereditary Canc Program, Barcelona, Spain
Brunet, J:
IDIBGI Catalan Inst Oncol, Genet Counseling Unit, Hereditary Canc Program, Girona, Spain
Pujana, MA:
IDIBELL Catalan Inst Oncol, Translat Res Lab, Breast Canc & Syst Biol Unit, Barcelona, Spain
Mai, PL:
NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA
Loud, JT:
NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA
Walsh, C:
Cedars Sinai Med Ctr, Womens Canc Program, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA
Lester, J:
Cedars Sinai Med Ctr, Womens Canc Program, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA
Orsulic, S:
Cedars Sinai Med Ctr, Womens Canc Program, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA
Narod, SA:
Univ Toronto, Womens Coll Res Inst, Toronto, ON, Canada
Herzog, J:
City Hope Natl Med Ctr, Clin Canc Genet, City Hope Clin Canc Genet Community Res Network, Duarte, CA USA
Sand, SR:
City Hope Natl Med Ctr, Clin Canc Genet, City Hope Clin Canc Genet Community Res Network, Duarte, CA USA
Tognazzo, S:
Ist Oncol Veneto IOV IRCCS, Immunol & Mol Oncol Unit, Padua, Italy
Agata, S:
Ist Oncol Veneto IOV IRCCS, Immunol & Mol Oncol Unit, Padua, Italy
Vaszko, T:
Natl Inst Oncol, Dept Mol Genet, Budapest, Hungary
Weaver, J:
Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
Stavropoulou, AV:
Natl Ctr Sci Res Demokritos, Mol Diagnost Lab, IRRP, Athens, Greece
Buys, SS:
Univ Utah, Sch Med, Dept Internal Med, Huntsman Canc Inst, Salt Lake City, UT USA
Romero, A:
Hosp Clin San Carlos, IdISSC, Mol Oncol Lab, Madrid, Spain
de la Hoya, M:
Hosp Clin San Carlos, IdISSC, Mol Oncol Lab, Madrid, Spain
Aittomaki, K:
Univ Helsinki, Cent Hosp, Dept Clin Genet, Helsinki, Finland
Muranen, TA:
Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland
Univ Helsinki, Cent Hosp, Helsinki, Finland
Duran, M:
Univ Valladolid IBGM UVA, Inst Biol & Mol Genet, Valladolid, Spain
Chung, WK:
Columbia Univ, Dept Pediat, New York, NY 10027 USA
Columbia Univ, Dept Med, New York, NY USA
Lasa, A:
Hosp Santa Creu & Sant Pau, Genet Serv, Barcelona, Spain
Dorfling, CM:
Univ Pretoria, Dept Genet, ZA-0002 Pretoria, South Africa
Miron, A:
Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA
Benitez, J:
Spanish Natl Canc Ctr CNIO, Human Genet Grp, Madrid, Spain
Biomed Network Rare Dis CIBERER, Madrid, Spain
Spanish Natl Canc Ctr CNIO, Genotyping Unit, Madrid, Spain
Senter, L:
Ohio State Univ, Ctr Comprehens Canc, Div Human Genet, Dept Internal Med, Columbus, OH 43210 USA
Huo, DZ:
Univ Chicago, Med Ctr, Ctr Clin Canc Genet & Global Hlth, Chicago, IL 60637 USA
Chan, SB:
Univ Calif San Francisco, Canc Risk Program, Helen Diller Family Canc Ctr, San Francisco, CA 94143 USA
Sokolenko, AP:
NN Petrov Oncol Res Inst, St Petersburg, Russia
Chiquette, J:
Univ Quebec, Unite Rech Sante Populat, Ctr Malad Sein Deschenes Fabia, Ctr Rech FRSQ,Ctr Hosp, Quebec City, PQ, Canada
Tihomirova, L:
Latvian Biomed Res & Study Ctr, Riga, Latvia
Friebel, TM:
Univ Penn, Philadelphia, PA 19104 USA
Agnarsson, BA:
Landspitali Univ Hosp, Reykjavik, Iceland
Univ Iceland, Sch Med, Reykjavik, Iceland
Lu, KH:
Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol & Clin Canc Genet, Houston, TX 77030 USA
Lejbkowicz, F:
Clalit Natl Israeli Canc Control Ctr, Haifa, Israel
Carmel Hosp, Dept Community Med & Epidemiol, Haifa, Israel
James, PA:
Peter MacCallum Canc Ctr, Familial Canc Ctr, Melbourne, Vic, Australia
Hall, P:
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
Dunning, AM:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England
Tessier, D:
Ctr Innovat Genome Quebec, Montreal, PQ, Canada
McGill Univ, Montreal, PQ, Canada
Cunningham, J:
Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
Mayo Clin, Rochester, MN USA
Slager, SL:
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Wang, C:
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Hart, S:
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Stevens, K:
Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
Mayo Clin, Rochester, MN USA
Simard, J:
Ctr Hosp Univ Quebec, Canc Genom Lab, Quebec City, PQ, Canada
Univ Laval, Quebec City, PQ, Canada
Pastinen, T:
McGill Univ, Dept Human Genet, Montreal, PQ, Canada
McGill Univ, Genome Quebec Innovat Ctr, Montreal, PQ, Canada
Pankratz, VS:
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Offit, K:
Mem Sloan Kettering Canc Ctr, Clin Genet Serv, New York, NY 10021 USA
Easton, DF:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Chenevix-Trench, G:
Queensland Inst Med Res, Dept Genet, Brisbane, Qld 4006, Australia
Antoniou, AC:
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Ctr Rech Cancerol Lyon, Natl Canc Genet Network, UNICANC Genet Grp, Paris, France.
Gold, Green Published, Green Accepted
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