The central biobank and virtual biobank of BIOMARKAPD: A resource for studies on neurodegenerative diseases


Por: Reijs B.L.R., Teunissen C.E., Goncharenko N., Betsou F., Blennow K., Baldeiras I., Brosseron F., Cavedo E., Fladby T., Froelich L., Gabryelewicz T., Gurvit H., Kapaki E., Koson P., Kulic L., Lehmann S., Lewczuk P., Lleó A., Maetzler W., De Mendonça A., Miller A.-M., Molinuevo J.L., Mollenhauer B., Parnetti L., Rot U., Schneider A., Simonsen A.H., Tagliavini F., Tsolaki M., Verbeek M.M., Verhey F.R.J., Zboch M., Winblad B., Scheltens P., Zetterberg H., Visser P.J.

Publicada: 1 ene 2015
Resumen:
Biobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme-Neurodegenerative Disease Research, which aims to improve the clinical use of body fluid markers for the diagnosis and prognosis of Alzheimer's disease (AD) and Parkinson's disease (PD). The objective was to standardize the assessment of existing assays and to validate novel fluid biomarkers for AD and PD. To support the validation of novel biomarkers and assays, a central and a virtual biobank for body fluids and associated data from subjects with neurodegenerative diseases have been established. In the central biobank, cerebrospinal fluid (CSF) and blood samples were collected according to the BIOMARKAPD standardized pre-analytical procedures and stored at Integrated BioBank of Luxembourg. The virtual biobank provides an overview of available CSF, plasma, serum, and DNA samples at each site. Currently, at the central biobank of BIOMARKAPD samples are available from over 400 subjects with normal cognition, mild cognitive impairment (MCI), AD, frontotemporal dementia (FTD), vascular dementia, multiple system atrophy, progressive supranuclear palsy, PD, PD with dementia, and dementia with Lewy bodies. The virtual biobank contains information on over 8,600 subjects with varying diagnoses from 21 local biobanks. A website has been launched to enable sample requests from the central biobank and virtual biobank. © 2015 Reijs, Teunissen, Goncharenko, Betsou, Blennow, Baldeiras, Brosseron, Cavedo, Fladby, Froelich, Gabryelewicz, Gurvit, Kapaki, Koson, Kulic, Lehmann, Lewczuk, Lleó, Maetzler, de Mendonça, Miller, Molinuevo, Mollenhauer, Parnetti, Rot, Schneider, Simonsen, Tagliavini, Tsolaki, Verbeek, Verhey, Zboch, Winblad, Scheltens, Zetterberg and Visser.

Filiaciones:
Reijs B.L.R.:
 Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, Netherlands

Teunissen C.E.:
 Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, Netherlands

Goncharenko N.:
 Integrated Biobank of Luxembourg, Luxembourg

Betsou F.:
 Integrated Biobank of Luxembourg, Luxembourg

Blennow K.:
 Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden

Baldeiras I.:
 Center for Neuroscience and Cell Biology, Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal

Brosseron F.:
 German Center for Neurodegenerative Diseases (DZNE), E.V. Clinical Neuroscience and Biomarkers, Bonn, Germany

Cavedo E.:
 Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Fatebenefratelli, Brescia, Italy

Fladby T.:
 Department of Neurology, Akershus University Hospital, Lørenskog, Norway

 Institute of Clinical Medicine, University of Oslo, Oslo, Norway

Froelich L.:
 Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

Gabryelewicz T.:
 Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

Gurvit H.:
 Behavioural Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

Kapaki E.:
 Neurochemistry Unit, Division of Cognitive and Movement Disorders, 1st Department of Neurology, National and Kapodistrian University of Athens, Athens, Greece

Koson P.:
 Department of Neurology, Slovak Medical University, University Hospital Bratislava, Bratislava, Slovakia

 Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia

Kulic L.:
 Division of Psychiatry Research, University of Zurich, Schlieren, Switzerland

Lehmann S.:
 Laboratoire de Biochimie Protéomique Clinique, INSERM U 1183, Institut de Médecine Régénérative et Biothérapies, CHRU de Montpellier, Université de Montpellier, Montpellier, France

Lewczuk P.:
 Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany

 Department of Neurodegeneration Diagnostics, Medical University of Bialystok, Bialystok, Poland

Lleó A.:
 Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau-Biomedical Research Institute Sant Pau, Barcelona, Spain

 Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain

Maetzler W.:
 Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany

 German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany

De Mendonça A.:
 Faculty of Medicine, University of Lisbon, Lisbon, Portugal

Miller A.-M.:
 Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin, Ireland

Molinuevo J.L.:
 ICN Hospital Clinic i Universitari, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain

Mollenhauer B.:
 Paracelsus-Elena-Klinik, Kassel, Germany

 Department of Neurosurgery and Institute of Neuropathology, University Medical Center Göttingen, Göttingen, Germany

Parnetti L.:
 Section of Neurology, Centre for Memory Disturbances, University of Perugia, Perugia, Italy

Rot U.:
 Laboratory for CSF Diagnostics, Department of Neurology, University Medical Centre, Ljubljana, Slovenia

Schneider A.:
 Department of Psychiatry and Psychotherapy, University Medical Center Göttingen and Translational Dementia Research Group, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany

Simonsen A.H.:
 Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Tagliavini F.:
 Unit of Neuropathology, Department of Diagnostics and Technology, IRCCS Foundation 'Carlo Besta' Neurological Institute, Milan, Italy

Tsolaki M.:
 3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece

Verbeek M.M.:
 Department of Neurology, Radboud Alzheimer Centre, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands

 Department of Laboratory Medicine, Radboud Alzheimer Centre, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands

Verhey F.R.J.:
 Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, Netherlands

Zboch M.:
 Research-Scientific-Didactic Centre of Dementia-Related Diseases, Wroclaw Medical University, Scinawa, Poland

Winblad B.:
 Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden

Scheltens P.:
 Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands

Zetterberg H.:
 Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden

 UCL Institute of Neurology, London, United Kingdom

Visser P.J.:
 Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, Netherlands

 Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands
ISSN: 16642295
Editorial
FRONTIERS MEDIA SA, AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND, Suiza
Tipo de documento: Article
Volumen: 6 Número:
Páginas:
WOS Id: 000363936700001
ID de PubMed: 26528237
imagen All Open Access, Gold

MÉTRICAS