The central biobank and virtual biobank of BIOMARKAPD: A resource for studies on neurodegenerative diseases
Por:
Reijs B.L.R., Teunissen C.E., Goncharenko N., Betsou F., Blennow K., Baldeiras I., Brosseron F., Cavedo E., Fladby T., Froelich L., Gabryelewicz T., Gurvit H., Kapaki E., Koson P., Kulic L., Lehmann S., Lewczuk P., Lleó A., Maetzler W., De Mendonça A., Miller A.-M., Molinuevo J.L., Mollenhauer B., Parnetti L., Rot U., Schneider A., Simonsen A.H., Tagliavini F., Tsolaki M., Verbeek M.M., Verhey F.R.J., Zboch M., Winblad B., Scheltens P., Zetterberg H., Visser P.J.
Publicada:
1 ene 2015
Resumen:
Biobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme-Neurodegenerative Disease Research, which aims to improve the clinical use of body fluid markers for the diagnosis and prognosis of Alzheimer's disease (AD) and Parkinson's disease (PD). The objective was to standardize the assessment of existing assays and to validate novel fluid biomarkers for AD and PD. To support the validation of novel biomarkers and assays, a central and a virtual biobank for body fluids and associated data from subjects with neurodegenerative diseases have been established. In the central biobank, cerebrospinal fluid (CSF) and blood samples were collected according to the BIOMARKAPD standardized pre-analytical procedures and stored at Integrated BioBank of Luxembourg. The virtual biobank provides an overview of available CSF, plasma, serum, and DNA samples at each site. Currently, at the central biobank of BIOMARKAPD samples are available from over 400 subjects with normal cognition, mild cognitive impairment (MCI), AD, frontotemporal dementia (FTD), vascular dementia, multiple system atrophy, progressive supranuclear palsy, PD, PD with dementia, and dementia with Lewy bodies. The virtual biobank contains information on over 8,600 subjects with varying diagnoses from 21 local biobanks. A website has been launched to enable sample requests from the central biobank and virtual biobank. © 2015 Reijs, Teunissen, Goncharenko, Betsou, Blennow, Baldeiras, Brosseron, Cavedo, Fladby, Froelich, Gabryelewicz, Gurvit, Kapaki, Koson, Kulic, Lehmann, Lewczuk, Lleó, Maetzler, de Mendonça, Miller, Molinuevo, Mollenhauer, Parnetti, Rot, Schneider, Simonsen, Tagliavini, Tsolaki, Verbeek, Verhey, Zboch, Winblad, Scheltens, Zetterberg and Visser.
Filiaciones:
Reijs B.L.R.:
Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, Netherlands
Teunissen C.E.:
Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, Netherlands
Goncharenko N.:
Integrated Biobank of Luxembourg, Luxembourg
Betsou F.:
Integrated Biobank of Luxembourg, Luxembourg
Blennow K.:
Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden
Baldeiras I.:
Center for Neuroscience and Cell Biology, Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Brosseron F.:
German Center for Neurodegenerative Diseases (DZNE), E.V. Clinical Neuroscience and Biomarkers, Bonn, Germany
Cavedo E.:
Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Fatebenefratelli, Brescia, Italy
Fladby T.:
Department of Neurology, Akershus University Hospital, Lørenskog, Norway
Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Froelich L.:
Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Gabryelewicz T.:
Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
Gurvit H.:
Behavioural Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
Kapaki E.:
Neurochemistry Unit, Division of Cognitive and Movement Disorders, 1st Department of Neurology, National and Kapodistrian University of Athens, Athens, Greece
Koson P.:
Department of Neurology, Slovak Medical University, University Hospital Bratislava, Bratislava, Slovakia
Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia
Kulic L.:
Division of Psychiatry Research, University of Zurich, Schlieren, Switzerland
Lehmann S.:
Laboratoire de Biochimie Protéomique Clinique, INSERM U 1183, Institut de Médecine Régénérative et Biothérapies, CHRU de Montpellier, Université de Montpellier, Montpellier, France
Lewczuk P.:
Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany
Department of Neurodegeneration Diagnostics, Medical University of Bialystok, Bialystok, Poland
Lleó A.:
Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau-Biomedical Research Institute Sant Pau, Barcelona, Spain
Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Maetzler W.:
Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany
De Mendonça A.:
Faculty of Medicine, University of Lisbon, Lisbon, Portugal
Miller A.-M.:
Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin, Ireland
Molinuevo J.L.:
ICN Hospital Clinic i Universitari, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
Mollenhauer B.:
Paracelsus-Elena-Klinik, Kassel, Germany
Department of Neurosurgery and Institute of Neuropathology, University Medical Center Göttingen, Göttingen, Germany
Parnetti L.:
Section of Neurology, Centre for Memory Disturbances, University of Perugia, Perugia, Italy
Rot U.:
Laboratory for CSF Diagnostics, Department of Neurology, University Medical Centre, Ljubljana, Slovenia
Schneider A.:
Department of Psychiatry and Psychotherapy, University Medical Center Göttingen and Translational Dementia Research Group, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany
Simonsen A.H.:
Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Tagliavini F.:
Unit of Neuropathology, Department of Diagnostics and Technology, IRCCS Foundation 'Carlo Besta' Neurological Institute, Milan, Italy
Tsolaki M.:
3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Verbeek M.M.:
Department of Neurology, Radboud Alzheimer Centre, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands
Department of Laboratory Medicine, Radboud Alzheimer Centre, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands
Verhey F.R.J.:
Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, Netherlands
Zboch M.:
Research-Scientific-Didactic Centre of Dementia-Related Diseases, Wroclaw Medical University, Scinawa, Poland
Winblad B.:
Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden
Scheltens P.:
Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands
Zetterberg H.:
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden
UCL Institute of Neurology, London, United Kingdom
Visser P.J.:
Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, Netherlands
Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands
All Open Access, Gold
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