Progress and prospective of plant sterol and plant stanol research: Report of the Maastricht meeting
Por:
Mackay D., Clifton P.M., Jones P.J.H., Awad A., Chapman J., Baker P.C., Gylling H., Jones P., Lutjohann D., Marz W., Moreau B., Ostlund R., Plat J., Rideout T., Ros E., Schaefer E., Daniel T., Vartiainen E., Weingartner O., Zampelas A., Berger A., Wester I., Rosin S., Meijer G., Trautwein E., Ras R., Antoine J.-M., Jeansen S., Koutnikova H., Short C., Messinger H., Horlacher P., Ehrhardt C., Brañes C., Harting T., Thompson G., Tikkanen M., Shaghaghi M.A., Baer D., Ansorena D., Baumgartner S., Blanco-Vaca F., Ellegard L., Carles J., Laitinen K., Myrie S., Miettinen T., Mymin D., Robinson M., Rompelberg C., Sarkkinen E., Silbernagel G., de Smet E., Loman S.
Publicada:
1 ene 2012
Resumen:
Abundant evidence over past decades shows that foods with added plant sterols and plant stanols lower serum LDL cholesterol concentrations. However, despite the overwhelming data, numerous scientific questions still remain. The objective of this paper is to summarize the considerations of 60 academic and industrial experts who participated in the scientific meeting in Maastricht, the Netherlands, on issues related to the health effects of plant sterols and plant stanols. The meeting participants discussed issues including efficacy profiling, heterogeneity in responsiveness, effects beyond LDL-C lowering, and food formulation aspects of plant sterol and stanol consumption. Furthermore, aspects related to the potential atherogenicity of elevated circulatory plant sterol concentrations were discussed. Until the potential atherogenicity of plant sterols is resolved, based on the results >200 clinical trials, the risk to benefit of plant sterol use is favorable. Evidence on these topics in plant sterol and plant stanol research was presented and used to reach consensus where possible. It was concluded that endpoint studies looking at plant sterol and plant stanol efficacy are needed, however, there was no clear opinion on the best marker and best design for such a study. Based on the current scientific evidence, plant sterols and plant stanols are recommended for use as dietary options to lower serum cholesterol. © 2012.
Filiaciones:
Mackay D.:
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada
Clifton P.M.:
Department of Medicine, University of Helsinki, Helsinki, Finland
Jones P.J.H.:
Department of Food Sciences, University of Manitoba, Winnipeg, Canada
Awad A.:
University at Buffalo, NY, United States
Chapman J.:
INSERM, Pitié-Salpétrière Hospital Paris, Paris, France
Baker P.C.:
IDI Heart and Diabetes Institute, Adelaide, Australia
Gylling H.:
Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
Helsinki University, Helsinki, Finland
Jones P.:
Department of Food Sciences, University of Manitoba, Winnipeg, Canada
Lutjohann D.:
Bonn University, Bonn, Germany
Marz W.:
Synlab Center of Lab Diagnostics Heidelberg, Germany
Moreau B.:
USDA ARS ERRC, Wyndmoor, PA, United States
Ostlund R.:
Washington University, St Louis, United States
Plat J.:
Department of Human Biology, Maastricht University, Maastricht, Netherlands
Maastricht University, Maastricht, Netherlands
Rideout T.:
University at Buffalo, NY, United States
Ros E.:
Lipid Clinic, End and Nutrition Service, Barcalona, Spain
Schaefer E.:
Tufts University, Boston, United States
Daniel T.:
University Hospital Leipzig, Leipzig, Germany
Vartiainen E.:
National Public Health Institute, Helsinki, Finland
Weingartner O.:
University of Homburg, Homburg/Saar, Germany
Zampelas A.:
Agricultural University of Athens, Athens, Greece
Meijer G.:
Unilever, Netherlands
Trautwein E.:
Unilever, Netherlands
Ras R.:
Unilever, Netherlands
Messinger H.:
BASF, Germany
Horlacher P.:
BASF, Germany
Ehrhardt C.:
BASF, Germany
Thompson G.:
Hammersmith Hospital, London, United Kingdom
Tikkanen M.:
Helsinki University, Helsinki, Finland
Shaghaghi M.A.:
University of Manitoba, Winnipeg, Canada
Baer D.:
Beltsville Human Nutrition Research Center, USDA, United States
Ansorena D.:
University of Navarra, Pamplona, Spain
Baumgartner S.:
Baker IDI Heart and Diabetes institute, Adelaide, Australia
Blanco-Vaca F.:
IIB Sant Pau, Barcelona, Spain
Ellegard L.:
Gothenburg University, Gothenburg, Sweden
Carles J.:
IIB Sant Pau, Barcelona, Spain
Escolà-Gil IIB Sant Pau, Barcelona, Spain
Laitinen K.:
University of Turku, Turku, Finland
Myrie S.:
University of Manitoba, Winnipeg, Canada
Miettinen T.:
Helsinki University, Helsinki, Finland
Mymin D.:
Health Sciences Centre, Winnipeg, Canada
Robinson M.:
ExCLAIM International, Amsterdam, Netherlands
Rompelberg C.:
RIVM, Netherlands
Sarkkinen E.:
Foodfiles, Kuopio, Finland
Silbernagel G.:
Eberhard-Karls-University, Tübingen, Germany
de Smet E.:
Maastricht University, Maastricht, Netherlands
Loman S.:
NutriClaim, Utrecht, Netherlands
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