Circulating soluble CD36 is similar in type 1 and type 2 diabetes mellitus versus non-diabetic subjects
Por:
Castelblanco E., Sanjurjo L., Falguera M., Hernández M., Fernandez-Real J.-M., Sarrias M.-R., Alonso N., Mauricio D.
Publicada:
1 ene 2019
Resumen:
The aim of this study was to determine whether plasma concentrations of sCD36 (soluble CD36) are associated with the presence of type 1 or type 2 diabetes. Plasma levels of sCD36 were analysed in 1023 subjects (225 type 1 diabetes (T1D) patients, 276 type 2 diabetes (T2D) patients, and 522 non-diabetic control subjects) using an enzyme-linked immunosorbent assay (ELISA). Multinomial and logistic regression models were performed to evaluate associations with sCD36 and its association with diabetes types. There were no significant differences in sCD36 (p = 0.144) among study groups, neither in head-to-head comparisons: non-diabetic versus T1D subjects (p = 0.180), non-diabetic versus T2D subjects (p = 0.583), and T1D versus T2D patients (p = 0.151). In the multinomial model, lower sCD36 concentrations were associated with older age (p < 0.001), tobacco exposure (p = 0.006), T2D (p = 0.020), and a higher-platelets count (p = 0.004). However, in logistic regression models of diabetes, sCD36 showed only a weak association with T2D. The current findings show a weak association of circulating sCD36 with type 2 diabetes and no association with T1D. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Filiaciones:
Castelblanco E.:
Department of Endocrinology & Nutrition, University, Hospital de la Santa Creu i Sant Pau & Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau), Barcelona, 08041, Spain
Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, 08907, Spain
Sanjurjo L.:
Innate Immunity Group, Health Sciences Research Institute Germans Trias i Pujol, Badalona, 08916, Spain
Falguera M.:
Primary Health Care Cervera, Gerència d’Atenció Primaria, Institut Català de la Salut, Unitat de Suport a la Recerca, Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Cervera, 25200, Spain
Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, Lleida, 25198, Spain
Hernández M.:
Department of Endocrinology & Nutrition, University Hospital Arnau de Vilanova & Biomedical Research Institute of Lleida (IRBLleida), Lleida, 25198, Spain
Fernandez-Real J.-M.:
Department of Diabetes, Endocrinology & Nutrition, Hospital Dr Josep Trueta & Biomedical Research Institute of Girona (IDIBGI), Girona, 17007, Spain
Centre for Biomedical Research on Physiopathology of Obesity and Nutrition (CIBEROBN), Girona, 17007, Spain
Sarrias M.-R.:
Innate Immunity Group, Health Sciences Research Institute Germans Trias i Pujol, Badalona, 08916, Spain
Centre for Biomedical Research on Liver and Digestive Diseases (CIBEREHD), Madrid, 28029, Spain
Alonso N.:
Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, 08907, Spain
Department of Endocrinology & Nutrition, University Hospital Germans Trias i Pujol & Health Sciences Research Institute, Badalona, 08916, Spain
Mauricio D.:
Department of Endocrinology & Nutrition, University, Hospital de la Santa Creu i Sant Pau & Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau), Barcelona, 08041, Spain
Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, 08907, Spain
Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, Lleida, 25198, Spain
gold, Green Published, Green Submitted, Gold, Green
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