IgG anti-high density lipoprotein antibodies are elevated in abdominal aortic aneurysm and associated with lipid profile and clinical features
Por:
Rodríguez-Carrio J., Lindholt J.S., Canyelles M., Martínez-López D., Tondo M., Blanco-Colio L.M., Michel J.-B., Escolà-Gil J.C., Suárez A., Martín-Ventura J.L.
Publicada:
1 ene 2020
Resumen:
High-density lipoproteins cholesterol (HDLc) levels are decreased in abdominal aortic aneurysm (AAA), which is hallmarked by autoimmunity and lipid aortic deposits. To investigate whether IgG anti-HDL antibodies were present in AAA and their potential association with clinical features, IgG anti-HDL and total IgG along with HDLc plasma levels were measured in 488 AAA patients and 184 controls from the Viborg Vascular (VIVA) study, and in tissue-conditioned media from AAA intraluminal thrombus and media layer samples compared to control aortas. Higher IgG anti-HDL levels were found in AAA compared to controls, even after correcting for total IgG, and after adjusting for potential confounders. IgG anti-HDL levels were correlated with aortic diameter in univariate and adjusted multivariate analyses. IgG anti-HDL antibodies were negatively associated with HDLc levels before and after correcting for potential confounders. Increased anti-HDL antibodies were identified in tissue-conditioned media from AAA samples compared to healthy aortas, with higher levels being observed in the media layer. In conclusion, increased IgG anti-HDL levels (both in plasma and in tissue) are linked to AAA, associated with aortic diameter and HDLc levels. These data suggest a potential immune response against HDL in AAA and support an emerging role of anti-HDL antibodies in AAA. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Filiaciones:
Rodríguez-Carrio J.:
Area of Immunology, Department of Functional Biology, University of Oviedo and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, 33006, Spain
Lindholt J.S.:
Centre of Individualized Medicine in Arterial Disease (CIMA), Department of Cardiology, Odense University Hospital, Odense, 5000, Denmark
Canyelles M.:
Institut d’Investigacions Biomèdiques (IIB) Sant Pau and CIBERDEM, Barcelona, 08041, Spain
Martínez-López D.:
IIS-Fundación Jiménez Díaz and CIBERCV, Madrid, 28040, Spain
Tondo M.:
Institut d’Investigacions Biomèdiques (IIB) Sant Pau and CIBERDEM, Barcelona, 08041, Spain
Blanco-Colio L.M.:
IIS-Fundación Jiménez Díaz and CIBERCV, Madrid, 28040, Spain
Michel J.-B.:
INSERM U1148, X. Bichat Hospital, Paris, 75018, France
Escolà-Gil J.C.:
Institut d’Investigacions Biomèdiques (IIB) Sant Pau and CIBERDEM, Barcelona, 08041, Spain
Suárez A.:
Area of Immunology, Department of Functional Biology, University of Oviedo and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, 33006, Spain
Martín-Ventura J.L.:
IIS-Fundación Jiménez Díaz and CIBERCV, Madrid, 28040, Spain
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