Assessment of inner retinal layers and choroidal thickness in type 1 diabetes mellitus: A cross-sectional study
Por:
Carbonell M., Alonso N., Castelblanco E., Real J., Ramírez-Morros A., Simó R., Hernández C., Jurjo C., Traveset A., Valldeperas X., Mauricio D.
Publicada:
1 ene 2019
Resumen:
Recent studies have shown that retinal neurodegeneration may precede visible vascular changes in diabetic retinopathy (DR). In addition, the relationship of choroidal thickness (CT) with DR stage is not well defined. To assess the inner retinal and choroidal structural changes in type 1 diabetic subjects (T1D), a cross-sectional study was conducted in 242 T1D patients and in 69 age-matched, non-diabetic individuals. The nasal retinal nerve fibre layer (RNFL) thickness was lower in T1D patients without DR (p < 0.001), with mild DR (p < 0.001), and with advanced DR (p < 0.001) compared to control subjects. The ganglion cell layer (GCL) thickness was lower in T1D patients with advanced DR compared to those with mild DR (p = 0.003) and without DR (p < 0.001) and compared to the control subjects (p < 0.001). T1D subjects with no DR and mild DR had higher CT than the control subjects, but the CT in T1D patients with advanced DR was lower (p = 0.038) than that in T1D subjects with mild DR and was not significantly different from that of the control subjects. In conclusion, T1D subjects showed a significant thinning of the nasal RNFL in the early stages of the disease, even before any vascular changes in the retina. A decrease in the GCL thickness during advanced DR stages was observed. Choroidal thickness was higher in T1D subjects without DR and in early DR stages but decreased in advanced stages. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Filiaciones:
Carbonell M.:
Department of Ophthalmology, University Hospital Germans Trias i Pujol, Badalona, 08916, Spain
Department of Surgery, Barcelona Autonomous University (UAB), Barcelona, 08035, Spain
Alonso N.:
Department of Endocrinology and Nutrition, University Hospital and Health Science Research, Institute Germans Trias i Pujol, Badalona, 08916, Spain
Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, 08907, Spain
Department of Medicine, Barcelona Autonomous University (UAB), Barcelona, 08035, Spain
Castelblanco E.:
Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, 08907, Spain
Department of Endocrinology & Nutrition, Hospital de la Santa Creu i Sant Pau, Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau), Barcelona, 08041, Spain
DAP-Cat Group, Unitat de Suport a la Recerca Barcelona, Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, 08025, Spain
Real J.:
Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, 08907, Spain
DAP-Cat Group, Unitat de Suport a la Recerca Barcelona, Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, 08025, Spain
Ramírez-Morros A.:
Department of Endocrinology and Nutrition, University Hospital and Health Science Research, Institute Germans Trias i Pujol, Badalona, 08916, Spain
Simó R.:
Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, 08907, Spain
Department of Endocrinology and Nutrition, Hospital Universitari Vall d’Hebron, Diabetes and Metabolism Research Unit, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia 08035, Spain
Hernández C.:
Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, 08907, Spain
Department of Endocrinology and Nutrition, Hospital Universitari Vall d’Hebron, Diabetes and Metabolism Research Unit, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia 08035, Spain
Jurjo C.:
Department of Ophthalmology, University Hospital Arnau de Vilanova, Lleida, 25198, Spain
Biomedical Research Institute of Lleida (IRBLleida) & University of Lleida, Lleida, 25198, Spain
Traveset A.:
Department of Ophthalmology, University Hospital Arnau de Vilanova, Lleida, 25198, Spain
Biomedical Research Institute of Lleida (IRBLleida) & University of Lleida, Lleida, 25198, Spain
Valldeperas X.:
Department of Ophthalmology, University Hospital Germans Trias i Pujol, Badalona, 08916, Spain
Department of Surgery, Barcelona Autonomous University (UAB), Barcelona, 08035, Spain
Mauricio D.:
Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, 08907, Spain
Department of Medicine, Barcelona Autonomous University (UAB), Barcelona, 08035, Spain
Department of Endocrinology & Nutrition, Hospital de la Santa Creu i Sant Pau, Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau), Barcelona, 08041, Spain
DAP-Cat Group, Unitat de Suport a la Recerca Barcelona, Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, 08025, Spain
Biomedical Research Institute of Lleida (IRBLleida) & University of Lleida, Lleida, 25198, Spain
gold, Green Published, All Open Access, Gold, Green
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