International prevalence and risk factors evaluation for drug-resistant Streptococcus pneumoniae pneumonia


Por: Aliberti S., Cook G.S., Babu B.L., Reyes L.F., Rodriguez A.H., Sanz F., Soni N.J., Anzueto A., Faverio P., Sadud R.F., Muhammad I., Prat C., Vendrell E., Kaimakamis E., Feneley A., Swarnakar R., Franzetti F., Carugati M., Morosi M., Monge E., Restrepo M.I., Aruj P.K., Attorri S., Barimboim E., Caeiro J.P., Garzón M.I., Cambursano V.H., Ceccato A., Chertcoff J., Lascar F., Di Tulio F., Díaz A.C., de Vedia L., Ganaha M.C., Lambert S., Lopardo G., Luna C.M., Malberti A.G., Morcillo N., Tartara S., Pensotti C., Pereyra B., Scapellato P.G., Stagnaro J.P., Shah S., Lötsch F., Thalhammer F., Anseeuw K., Francois C.A., Van Braeckel E., Vincent J.L., Djimon M.Z., Bashi J., Dodo R., Nouér S.A., Chipev P., Encheva M., Miteva D., Petkova D., Balkissou A.D., Yone E.W.P., Ngahane B.H.M., Shen N., Xu J.-F., Rico C.A.B., Buitrago R., Paternina F.J.P., Ntumba J.-M.K., Carevic V.V., Jakopovic M., Jankovic M., Matkovic Z., Mitrecic I., Jacobsson M.-L.B., Christensen A.B., Bødtger U.C.H., Meyer C.N., Jensen A.V., Baunbæk-Knudsen G., Petersen P.T., Andersen S., El-Wahhab I.E.-S.A., Morsy N.E., Shafiek H., Sobh E., Abdulsemed K.A., Bertrand F., Brun-Buisson C., de Montmollin E., Fartoukh M., Messika J., Tattevin P., Khoury A., Ebruke B., Dreher M., Kolditz M., Meisinger M., Pletz M.W., Hagel S., Rupp J., Schaberg T., Spielmanns M., Creutz P., Suttorp N., Siaw-Lartey B., Dimakou K., Papapetrou D., Tsigou E., Ampazis D., Bhatia M., Dhar R., D’souza G., Garg R., Koul P.A., Mahesh P.A., Jayaraj B.S., Narayan K.V., Udnur H.B., Krishnamurthy S.B., Kant S., Limaye S., Salvi S., Golshani K., Keatings V.M., Martin-Loeches I., Maor Y., Strahilevitz J., Battaglia S., Carrabba M., Ceriana P., Confalonieri M., D’Arminio Monforte A., Del Prato B., De Rosa M., Fantini R., Fiorentino G., Gammino M.A., Menzella F., Milani G., Nava S., Palmiero G., Petrino R., Gabrielli B., Rossi P., Sorino C., Steinhilber G., Zanforlin A., Carone M., Patella V., Scarlata S., Comel A., Kurahashi K., Bacha Z.A., Ugalde D.B., Zuñiga O.C., Villegas J.F., Medenica M., van de Garde E.M.W., Mihsra D.R., Shrestha P., Ridgeon E., Awokola B.I., Nwankwo O.N.O., Olufunlola A.B., Olumide S., Ukwaja K.N., Irfan M., Minarowski L., Szymon S., Froes F., Leuschner P., Meireles M., Ferrão C., Neves J., Ravara S.B., Brocovschii V., Ion C., Rusu D., Toma C., Chirita D., Dorobat C.M., Birkun A., Kaluzhenina A., Almotairi A., Bukhary Z.A.A., Edathodu J., Fathy A., Enani A.M.A., Mohamed N.E., Memon J.U., Bella A., Bogdanovic N., Milenkovic B., Pesut D., Borderìas L., Garcia N.M.B., Alarcón H.C., Cilloniz C., Torres A., Diaz-Brito V., Casas X., González A.E., Fernández-Almira M.L., Gallego M., Gaspar-García I., Del Castillo J.G., Victoria P.J., Martínez E.L., de Molina R.M., Marcos P.J., Menéndez R., Pando-Sandoval A., Aymerich C.P., de la Torre A.L., García-Olivé I., Rello J., Moyano S., Sibila O., Rodrigo-Troyano A., Solé-Violán J., Uranga A., van Boven J.F.M., Torra E.V., Pujol J.A., Feldman C., Yum H.K., Fiogbe A.A., Yangui F., Bilaceroglu S., Dalar L., Yilmaz U., Bogomolov A., Elahi N., Dhasmana D.J., Ions R., Skeemer J., Woltmann G., Hancock C., Hill A.T., Rudran B., Ruiz-Buitrago S., Campbell M., Whitaker P., Youzguin A., Singanayagam A., Allen K.S., Brito V., Dietz J., Dysart C.E., Kellie S.M., Franco-Sadud R.A., Meier G., Gaga M., Holland T.L., Bergin S.P., Kheir F., Landmeier M., Lois M., Nair G.B., Patel H., Reyes K., Rodriguez-Cintron W., Saito S., Noda J., Hinojosa C.I., Levine S.M., Angel L.F., Whitlow K.S., Hipskind J., Sukhija K., Totten V., Wunderink R.G., Shah R.D., Mateyo K.J., Noriega L., Alvarado E., Aman M., Labra L.

Publicada: 1 ene 2019
Resumen:
Objective: Streptococcus pneumoniae is the most frequent bacterial pathogen isolated in subjects with Community-acquired pneumonia (CAP) worldwide. Limited data are available regarding the current global burden and risk factors associated with drug-resistant Streptococcus pneumoniae (DRSP) in CAP subjects. We assessed the multinational prevalence and risk factors for DRSP-CAP in a multinational point-prevalence study. Design: The prevalence of DRSP-CAP was assessed by identification of DRSP in blood or respiratory samples among adults hospitalized with CAP in 54 countries. Prevalence and risk factors were compared among subjects that had microbiological testing and antibiotic susceptibility data. Multivariate logistic regressions were used to identify risk factors independently associated with DRSP-CAP. Results: 3,193 subjects were included in the study. The global prevalence of DRSP-CAP was 1.3% and continental prevalence rates were 7.0% in Africa, 1.2% in Asia, and 1.0% in South America, Europe, and North America, respectively. Macrolide resistance was most frequently identified in subjects with DRSP-CAP (0.6%) followed by penicillin resistance (0.5%). Subjects in Africa were more likely to have DRSP-CAP (OR: 7.6; 95%CI: 3.34-15.35, p<0.001) when compared to centres representing other continents. Conclusions: This multinational point-prevalence study found a low global prevalence of DRSP-CAP that may impact guideline development and antimicrobial policies. © 2019

Filiaciones:
Aliberti S.:
 Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Respiratory Unit and Cystic Fibrosis Adult Center, University of Milan, Department of Pathophysiology and Transplantation, Milan, Italy

Cook G.S.:
 Division of Pulmonary Diseases & Critical Care Medicine, The University of Texas Health Science Centre at San Antonio, San Antonio, TX, United States

Babu B.L.:
 Division of Pulmonary Diseases & Critical Care Medicine, The University of Texas Health Science Centre at San Antonio, San Antonio, TX, United States

 Division of Pulmonary Diseases & Critical Care Medicine, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, TX 78229, United States

Reyes L.F.:
 Department of microbiology, Universidad de la Sabana, Bogota, Colombia

Rodriguez A.H.:
 Critical Care Medicine, Hospital Universitari Joan XXIII, Rovira & Virgili University and CIBERes (Biomedical Research Network of Respiratory disease), Tarragona, Spain

Sanz F.:
 Pulmonology Department, Consorci Hospital General Universitari de Valencia, Valencia, Spain

 Servicio de Neumología, Consorci Hospital General Universitari de Valencia, Valencia, Spain

Soni N.J.:
 Division of Pulmonary Diseases & Critical Care Medicine, The University of Texas Health Science Centre at San Antonio, San Antonio, TX, United States

 Division of Pulmonary Diseases & Critical Care Medicine, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, TX 78229, United States

 Divisions of Hospital Medicine & Pulmonary/Critical Care Medicine, South Texas Veterans Health Care System, University of Texas Health Science Center San Antonio, San Antonio, TX, United States

Anzueto A.:
 Division of Pulmonary Diseases & Critical Care Medicine, The University of Texas Health Science Centre at San Antonio, San Antonio, TX, United States

 Division of Pulmonary Diseases & Critical Care Medicine, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, TX 78229, United States

 Divisions of Hospital Medicine & Pulmonary/Critical Care Medicine, South Texas Veterans Health Care System, University of Texas Health Science Center San Antonio, San Antonio, TX, United States

Faverio P.:
 Cardio-Thoracic-Vascular Department, University of Milan Bicocca, Respiratory Unit, San Gerardo Hospital, ASST di Monza, Monza, Italy

Sadud R.F.:
 Section of Hospital Medicine, Medical College of WisconsinWI, United States

Muhammad I.:
 Section of Pulmonary and Critical Care Medicine, Department of Medicine, Aga Khan University, Karachi, 74800, Pakistan

Prat C.:
 Microbiology Department, Hospital Universitari Germans Trias i Pujol, Institut d’Investigació Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona, CIBER Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Spain

Vendrell E.:
 Intensive Care Medicine, Hospital de Mataró, Spain

Kaimakamis E.:
 Intensive Care Unit, “G. Papanikolaou” General Hospital of Thessaloniki, Greece

Feneley A.:
 University Hospitals of Leicester NHS Trust, Leicester, United Kingdom

 University Hospitals of Leicester NHS Trust and University of Leicester, Leicester, United Kingdom

Swarnakar R.:
 Getwell Hospital & Research Institute, Dhantoli, Nagpur, India

Franzetti F.:
 Department of Biomedical and Clinical Sciences, Division of Infectious Diseases, Luigi Sacco Hospital, Università degli Studi di Milano, Milan, Italy

Carugati M.:
 Department of Biomedical and Clinical Sciences, Division of Infectious Diseases, Luigi Sacco Hospital, Università degli Studi di Milano, Milan, Italy

Morosi M.:
 Department of Biomedical and Clinical Sciences, Division of Infectious Diseases, Luigi Sacco Hospital, Università degli Studi di Milano, Milan, Italy

Monge E.:
 Department of Biomedical and Clinical Sciences, Division of Infectious Diseases, Luigi Sacco Hospital, Università degli Studi di Milano, Milan, Italy

Restrepo M.I.:
 Division of Pulmonary Diseases & Critical Care Medicine, The University of Texas Health Science Centre at San Antonio, San Antonio, TX, United States

 Division of Pulmonary Diseases & Critical Care Medicine, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, TX 78229, United States

Aruj P.K.:
 Department of Internal Medicine, University Hospital Alfredo Lanari, Buenos Aires, Argentina

Attorri S.:
 Hospital Luis Lago maggiore, Mendoza, Argentina

Barimboim E.:
 Hospital Central de Mendoza, Argentina

Caeiro J.P.:
 Hospital Privado Universitario, Córdoba, Argentina

Garzón M.I.:
 Hospital Privado Universitario, Córdoba, Argentina

Cambursano V.H.:
 V.H. Dr Cazaux A. Servicio de Neumologia, Hospital Rawson, Córdoba, Argentina

Ceccato A.:
 Hospital Nacional Prof Alejandro Posadas, Argentina

Chertcoff J.:
 Critical Care Unit and Respiratory Medicine, Buenos Aires British Hospital, Buenos Aires, Argentina

Lascar F.:
 Critical Care Unit and Respiratory Medicine, Buenos Aires British Hospital, Buenos Aires, Argentina

Di Tulio F.:
 Critical Care Unit and Respiratory Medicine, Buenos Aires British Hospital, Buenos Aires, Argentina

Díaz A.C.:
 Hospital General Alvear, Ciudad, Mendoza, Argentina

de Vedia L.:
 Respiratory Intensive Care Unit, Hospital Muñiz, Buenos Aires, Argentina

Ganaha M.C.:
 Infectious Diseases Ward, Hospital Interzonal General de Agudos "Vicente Lopez y Planes" from General Rodriguez, Buenos Aires, Argentina

Lambert S.:
 Hospital El Cruce-Alta Complejidad en Red, Argentina

Lopardo G.:
 Hospital Bernardo Houssay, Vicente López, Argentina

Luna C.M.:
 Pulmonary Medicine Division, Department of Medicine, Hospital de Clínicas, Universidad de Buenos Aires, Argentina

Malberti A.G.:
 Hospital Nuestra Señora del Carmen, Argentina

Morcillo N.:
 Hospital Zonal Especializado de Agudos y Crónicos Dr. Antonio A. Cetrangolo, Argentina

Tartara S.:
 Hospital Zonal Especializado de Agudos y Crónicos Dr. Antonio A. Cetrangolo, Argentina

Pensotti C.:
 Infectious Diseases and Infection Control Department, Clinica Privada Monte Grande, Buenos Aires, Argentina

Pereyra B.:
 Hospital San Roque, Córdoba, Argentina

Scapellato P.G.:
 Infectious Diseases Department, Hospital D.F. Santojanni, Argentina

Stagnaro J.P.:
 HZGA Mi Pueblo, Florencio Varela, Argentina

Shah S.:
 Department of General medicine, Austin hospital, Heidelberg, Australia

Lötsch F.:
 Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Austria

Thalhammer F.:
 Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Austria

Anseeuw K.:
 ZNA Campus Stuivenberg, Antwerp, Belgium

Francois C.A.:
 Anesthesia and critical care department, Erasme university hospital, Brussels, Belgium

Van Braeckel E.:
 Department of Respiratory Medicine, Ghent University Hospital, Belgium

Vincent J.L.:
 Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium

Djimon M.Z.:
 Centre Hospitalier Universitaire HKM of Cotonou, Benin

Bashi J.:
 Centre Hospitalier Universitaire HKM of Cotonou, Benin

Dodo R.:
 Centre Hospitalier Universitaire HKM of Cotonou, Benin

Nouér S.A.:
 Federal University of Rio de Janeiro, Brazil

Chipev P.:
 Clinic of Pulmonary Diseases, Military Medical Academy, Sofia, Bulgaria

Encheva M.:
 Clinic of Pulmonary Diseases, Military Medical Academy, Sofia, Bulgaria

Miteva D.:
 UMHAT "St. Marina", Varna, Bulgaria

Petkova D.:
 University Hospital Varna, Bulgaria

Balkissou A.D.:
 Yaounde Jamot Hospital, Yaounde, Cameroon

Yone E.W.P.:
 Département de Médecine Interne, University of Yaounde, Yaoundé, Cameroon

Ngahane B.H.M.:
 Douala General Hospital, Douala, Cameroon

Shen N.:
 Respiratory Medicine, Peking University Third Hospital, Beijing, China

Xu J.-F.:
 Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, China

Rico C.A.B.:
 Clinica Shaio, Bogota, Colombia

Buitrago R.:
 Clinica Shaio, Bogota, Colombia

Paternina F.J.P.:
 Las Americas Clinic, Medellin, Colombia

Ntumba J.-M.K.:
 Cliniques Universitaires de Kinshasa, Democratic Republic Congo

Carevic V.V.:
 Interne Medicine, Dubrovnik, Croatia

Jakopovic M.:
 Medical School, University of Zagreb, Department for Respiratory Diseases Jordanovac, University Hospital Centre Zagreb, Zagreb, Croatia

Jankovic M.:
 University Hospital Center Zagreb, Department for Respiratory Diseases, Zagreb, Croatia

Matkovic Z.:
 University Hospital Dubrava, Zagreb, Croatia

Mitrecic I.:
 Karlovac general hospital, Karlovac, Croatia

Jacobsson M.-L.B.:
 Emergency Department in North Zealand s Hospital, Hillerød, Denmark

Christensen A.B.:
 Department of Anaethesiology, Viborg Region Hospital, Denmark

Bødtger U.C.H.:
 Department of Pulmonology, Naestved Hospital, Denmark

Meyer C.N.:
 Department of Internal Medicine, Roskilde Hospital, Copenhagen University Hospital, Roskilde, Denmark

Jensen A.V.:
 Department of Lung-and Infectious Diseases, Nord-sjællands Hospital, Hillerød, Denmark

Baunbæk-Knudsen G.:
 Department of Lung-and Infectious Diseases, Nord-sjællands Hospital, Hillerød, Denmark

Petersen P.T.:
 Department of Lung-and Infectious Diseases, Nord-sjællands Hospital, Hillerød, Denmark

Andersen S.:
 Department of Lung-and Infectious Diseases, Nord-sjællands Hospital, Hillerød, Denmark

El-Wahhab I.E.-S.A.:
 Thoracic Medicine, Faculty of Medicine-Mansoura University, Egypt

Morsy N.E.:
 Pulmonary, Critical Care and Sleep Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Shafiek H.:
 Chest diseases department, Faculty of Medicine, Alexandria University, Egypt

Sobh E.:
 Chest Diseases Department, Al-Azhar University, Cairo, Egypt

Abdulsemed K.A.:
 Department of Medical Laboratory Science and Pathology, College of Health sciences, Mycobacteriology Research Centre, Institute of Biotechnology Research, Jimma University, Jimma, Ethiopia

Bertrand F.:
 Critical care Unit, Robert Ballanger Hospital, Aulnay sous Bois, France

Brun-Buisson C.:
 Univ Hospital Henri Mondor, Créteil, 94000, France

de Montmollin E.:
 Intensive care unit, Hôpital Delafontaine, Centre hospitalier de Saint-Denis, Saint-Denis, France

Fartoukh M.:
 Unité de réanimation médico-chirurgicale, Pôle Thorax Voies aériennes, Hôpital Tenon, Groupe Hospitalier Est Parisien, France

Messika J.:
 Publique-Hôpital de Paris, Service de Réanimation Médico-chirurgicale, Hôpital Louis Mourier, Colombes, France

 Université Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, Paris, France

Tattevin P.:
 Infectious Diseases &ICU, Pontchaillou University Hospital, Rennes, France

Khoury A.:
 Department of Emergency Medicine & Critical Care, University of Franche-Comté, Medical Center, France

Ebruke B.:
 Medical Research Council Unit, Gambia

Dreher M.:
 Department of Cardiology, Pneumology, Vascular Medicine and Intensive Care Medicine, University Hospital Aachen, Aachen, Germany

Kolditz M.:
 Division of Pulmonology, Medical Department I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany

Meisinger M.:
 Klinikum Niederlausitz GmbH, Klinik für Innere Medizin und Intensivmedizin, Senftenberg, Germany

Pletz M.W.:
 Center for Infectious Diseases and Infection Control, Jena University Hospital, Germany

Hagel S.:
 Center for Infectious Diseases and Infection Control, Jena University Hospital, Germany

Rupp J.:
 Department of Molecular and Infectious Diseases, University of Lübeck, Lübeck, Germany

Schaberg T.:
 Zentrum für Pneumologie, Agaplesion Diakonieklinikum Rotenburg, Germany

Spielmanns M.:
 Internal Medicine Department, Pulmonary rehabilitation and Department of Health, School of Medicine, University Witten-Herdecke, St. Remigius-Hospital, Leverkusen, Germany

Creutz P.:
 Department of Infectious Disease and Respiratory Medicine, Charité-University Medicine, Berlin, Germany

Suttorp N.:
 Department of Infectious Disease and Respiratory Medicine, Charité-University Medicine, Berlin, Germany

Siaw-Lartey B.:
 Komfo-Anokye Teaching Hospital, Kumasi, Ghana

Dimakou K.:
 5th Respiratory Medicine Dpt, ‘’SOTIRIA” Chest Hospital, Athens, 11527, Greece

Papapetrou D.:
 Medical Group of Athens (Paleo Faliro Clinic), Athens, Greece

Tsigou E.:
 Agioi Anargiroi Hospital, Kifissia, Athens, Greece

Ampazis D.:
 Agioi Anargiroi Hospital, Kifissia, Athens, Greece

Bhatia M.:
 S.S. Hospital IMS BHU Varanasi, India

Dhar R.:
 Fortis Hospitals, Kolkata, India

D’souza G.:
 Department of Pulmonary Medicine, St. John’s Medical College Hospital, Bangalore, 560034, India

Garg R.:
 Department of Respiratory Medicine, King George’s Medical University UP, Lucknow, India

Koul P.A.:
 Department of Internal & Pulmonary Medicine, SheriKashmir Institute of Medical Sciences, Srinagar, India

Mahesh P.A.:
 Department of Pulmonary Medicine, JSS Medical College, JSS University, Mysore, India

Jayaraj B.S.:
 Department of Pulmonary Medicine, JSS Medical College, JSS University, Mysore, India

Narayan K.V.:
 Pulmonary Medicine, Government Medical College KozhikodeKerala, India

Udnur H.B.:
 Columbia Asia Hospital, Hebbal, Bengaluru, Karnataka, India

Krishnamurthy S.B.:
 Columbia Asia Hospital, Hebbal, Bengaluru, Karnataka, India

Kant S.:
 Department of Respiratory Medicine, King George’s Medical University, Chowk, Lucknow, Uttar Pradesh 226003, India

Limaye S.:
 Respiratory Research Network of India (RRNI) from the Chest Research Foundation, Pune, India

Salvi S.:
 Respiratory Research Network of India (RRNI) from the Chest Research Foundation, Pune, India

Golshani K.:
 Isfahan University of Medical Sciences, Iran

Keatings V.M.:
 Letterkenny General Hospital, Co. Donegal, Ireland

Martin-Loeches I.:
 Multidisciplinary Intensive Care Research Organization (MICRO), St James’s University Hospital, Trinity Centre for Health Sciences, Dublin, Ireland

Maor Y.:
 Infectious Disease Unit, Affiliated to Tel Aviv University, Wolfson Medical Center, Holon, Israel

Strahilevitz J.:
 Department of Clinical Microbiology & Infectious Diseases, Hadassah-Hebrew University, Jerusalem, Israel

Battaglia S.:
 University of Palermo, Pneumologia DiBiMIS, Palermo, Italy

Carrabba M.:
 Internal Medicine Department, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, 20122, Italy

Ceriana P.:
 Pulmonary rehabilitation, IRCCS Fondazione Maugeri, Pavia, 27100, Italy

Confalonieri M.:
 Department of Pulmunology, University Hospital, Trieste, Italy

D’Arminio Monforte A.:
 Department of Health Sciences, Clinic of Infectious Disease, San Paolo Hospital, University of Milan, Italy

Del Prato B.:
 Interventional Pneumology, Hospital Antonio Cardarelli, Naples, Italy

De Rosa M.:
 UOC Pneumologia P.O. San Filippo Neri ASL RM E, Roma, Italy

Fantini R.:
 Respiratory Diseases clinic, Policlinico di Modena, Modena, 41124, Italy

Fiorentino G.:
 UOC Fisiopatologia e Riabilitazione Respiratoria AO Ospedali dei Colli PO Monaldi, Italy

Gammino M.A.:
 Pulmonary Medicine Unit, San Martino Hospital, ASL 5 Oristano, Sardegna, Italy

Menzella F.:
 Department of Cardiac-Thoracic-Vascular and Intensive Care Medicine, Pneumology Unit, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy

Milani G.:
 Azienda Ospedaliera Sant Anna di Como, Presidio Ospedale S. Anna Nuovo, Unità Operativa di Pneumologia, Como, Italy

Nava S.:
 Alma Mater University of Bologna, DIMES, Respiratory and Critical Care Unit Sant’Orsola Malpighi Hospital, Italy

Palmiero G.:
 Respiratory Unit, Versilia Hospital, Azienda USL 12 Viareggio, Lido di Camaiore, Lucca, Italy

Petrino R.:
 Emergency Medicine Unit, S. Andrea Hospital, Vercelli, Italy

Gabrielli B.:
 Emergency Medicine Unit, S. Andrea Hospital, Vercelli, Italy

Rossi P.:
 Internal Medicine Department, Azienda Ospedaliero-Universitaria S. Maria della Misericordia, Udine, Italy

Sorino C.:
 Pulmonology Unit, A.O. Sant’Anna di Como, Italy

Steinhilber G.:
 Spedali Civili Brescia, U.O. Pneumologia e Fisiopatologia Respiratoria, Brescia, Italy

Zanforlin A.:
 ULSS 18 Rovigo, Ospedale San Luca, Trecenta, RO 45027, Italy

Carone M.:
 Fondazione Salvatore Maugeri, IRCCS, Cassano Murge, Italy

Patella V.:
 Allergology and Clinical Immunology Unit, Department of Medical Sciences, Battipaglia Hospital, Battipaglia, Salerno, Italy

Scarlata S.:
 Geriatrics, Unit of Respiratory Pathophysiology and Thoracic Endoscopy, Campus Bio Medico University and Teaching Hospital, Rome, Italy

Comel A.:
 UO Pneumologia, Ospedale Pederzoli, Peschiera del Garda, Italy

Kurahashi K.:
 Yokohama City University Medical Center, Japan

Bacha Z.A.:
 Medicine school, St Joseph University, Beyrouth, Lebanon

Ugalde D.B.:
 National Institute of Respiratory Diseases, Mexico

Zuñiga O.C.:
 Hospital General de Mexicali, Mexicali, Baja California, Mexico

Villegas J.F.:
 Hospital Universitario Monterrey, n. lCP 64030, Mexico

Medenica M.:
 Hospital for Lung Diseases-Brezovik, Niksic, Montenegro

van de Garde E.M.W.:
 Dept. Clinical Pharmacy, St. Antonius Hospital, Utrecht/Nieuwegein, Netherlands

Mihsra D.R.:
 Internal Medicine, BP Koirala Institute of Health Sciences, Nepal

Shrestha P.:
 Oxford University Clinical Research Unit, Patan Hospital, Nepal

Ridgeon E.:
 Medical Research Institute of New Zealand, New Zealand

Awokola B.I.:
 Department of Family Medicine & Primary Care, Lily Hospitals Limited, Warri, Nigeria

Nwankwo O.N.O.:
 University of Calabar Teaching Hospital, Calabar, Nigeria

Olufunlola A.B.:
 Olabisi Onabanjo University teaching hospital, Sagamu, Ogun State, Nigeria

Olumide S.:
 Department of Medicine (Pulmonary Unit), University College Hospital, Ibadan, Nigeria

Ukwaja K.N.:
 Department of Medicine, Federal Teaching Hospital AbakalikiEbonyi State, Nigeria

Irfan M.:
 Section of Pulmonary and Critical Care Medicine, Department of Medicine, Aga Khan University, Karachi, 74800, Pakistan

Minarowski L.:
 Department of Lung Diseases and Tuberculosis, Medical University of Bialystok, Poland

Szymon S.:
 Department of Pneumology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland

Froes F.:
 Hospital Pulido Valente-CHLN, Lisboa, Portugal

Leuschner P.:
 Centro Hospitalar do Porto, Porto, Portugal

 Serviço de Medicina, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, Porto, 4099–001, Portugal

Meireles M.:
 Serviço de Medicina, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, Porto, 4099–001, Portugal

Ferrão C.:
 Serviço de Medicina, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, Porto, 4099–001, Portugal

Neves J.:
 Serviço de Medicina, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, Porto, 4099-001, Portugal

Ravara S.B.:
 Faculty of Health Sciences, University of Beira Interior, Cova da Beira Hospital Center, Covilhã, 6200–251, Portugal

Brocovschii V.:
 Department of Pneumology & Allergology, State University of Medicine and Pharmacy "Nicolae Testemitanu", Moldova

Ion C.:
 Clinic of Anesthesia and Intensive Care "Valeriu Ghrerg", Institute of Emergency Medicine, State University of Medicine and Pharmacy "Nicolae Testemitanu", Chisinau, Moldova

Rusu D.:
 SMFU "N. Testemitanu", Chisinau, Moldova

Toma C.:
 Department of Pneumology & Allergology, State University of Medicine and Pharmacy "Nicolae Testemitanu”, Chisinau, Moldova

Chirita D.:
 Hospital Sfantul Stefan, Bucharest, Romania

Dorobat C.M.:
 Universitatea de Medicina si Farmacie “Gr. T. Popa” I a s i Facultatea de Medicina Stomatologica, Spitalul Clinic de Boli Infectioase “Sfânta Parascheva”, I a s i str. Octav Botez, nr. 2, Iasi, 700116, Romania

Birkun A.:
 Department of Anesthesiology, Critical Care and Emergency Medicine, Medical Academy named after S. I. Georgievsky, Russian Federation

Kaluzhenina A.:
 Volgograd State Medical University, Russian Federation

Almotairi A.:
 King Fahad medical City (KFMC), Riyadh, Saudi Arabia

Bukhary Z.A.A.:
 College of Medicine, Taibah University, Medina, Saudi Arabia

Edathodu J.:
 Al Faisal University, King Faisal Specialist Hospital, Riyadh, Saudi Arabia

Fathy A.:
 Pulmonary and respiratory critical care Medicine, Mansoura University Egypt, Affiliate at Taibah University, Saudi Arabia

Enani A.M.A.:
 Infectious Diseases Section, Medical Specialties Department, King Fahad Medical City, Riyadh, Saudi Arabia

Mohamed N.E.:
 Infectious Diseases Section, Medical Specialties Department, King Fahad Medical City, Riyadh, Saudi Arabia

Memon J.U.:
 Pulmonology Division, Department of Internal Medicine, King Fahad Hospital, Hofuf, Al Ahasa31982, Saudi Arabia

Bella A.:
 Dammam University-Saudi Arabia and King Fahad Hospital, Saudi Arabia

Bogdanovic N.:
 Pulmonary department of KHC Dr. Dragiša Mišovic, Belgrade, Serbia

Milenkovic B.:
 Clinic for Pulmonary Diseases, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Pesut D.:
 University of Belgrade School of Medicine, Teaching Hospital of Pulmonology, Clinical Centre of Serbia, Belgrade, Serbia

Borderìas L.:
 Respiratory and Sleep Unit, Hospital San Jorge, Huesca, Spain

Garcia N.M.B.:
 Barcelona Policlínic and Moises Broggi Hospital at sant Joan Despí, Spain

Alarcón H.C.:
 Sant Hospital Seu de Urgell, Catalonia, Spain

Cilloniz C.:
 Department of Pneumology, Institut Clinic del Tórax, Hospital Clinic of Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona (UB), Spain

Torres A.:
 Department of Pneumology, Institut Clinic del Tórax, Hospital Clinic of Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona (UB), Spain

Diaz-Brito V.:
 Infectious diseases Unit and Pneumology Service, Parc Sanitari Sant Joan de Deu, Sant Boi, Barcelona, Spain

Casas X.:
 Infectious diseases Unit and Pneumology Service, Parc Sanitari Sant Joan de Deu, Sant Boi, Barcelona, Spain

González A.E.:
 Hospital Complex of Pontevedra, Spain

Fernández-Almira M.L.:
 Medicina Interna, Hospital Universitario Central de Asturias, Spain

Gallego M.:
 Department of Respiratory Medicine, Hospital de Sabadell, Institut Universitari Parc Taulí-UAB, Sabadell, Spain

 CIBER de Enfermedades Respiratorias, CIBERES, Bunyola, Spain

Gaspar-García I.:
 Department of Respiratory Medicine, Hospital Costa del Sol, Marbella, Málaga, Spain

Del Castillo J.G.:
 Emergency Department, Hospital Universitario Clínico San Carlos, Madrid, Spain

Victoria P.J.:
 Hospital General Universitario de Alicante, Alicante, Spain

Martínez E.L.:
 Hospital Mollet, Barcelona, Spain

de Molina R.M.:
 University Hospital Puerta de Hierro Majadahonda, Madrid, Spain

Marcos P.J.:
 Servicio de Neumología, Complejo Hospitalario Universitario de A Coruña (CHUAC), INIBIC, Sergas, Universidade de A Coruña (UDC), Spain

Menéndez R.:
 Pneumology Service, Universitary and Polytechnic Hospital La Fe, Valencia, Spain

Pando-Sandoval A.:
 Hospital Universitario Central de Asturias. Area de Gestion Clinica de Pulmon. Servicio de Neumologia, Oviedo, Spain

Aymerich C.P.:
 Microbiology Department and Pneumology Department, Hospital Universitari Germans Trias i Pujol, Institut d’Investigació Germans Trias i Pujol, Badalona, Spain

 Universitat Autònoma de Barcelona. CIBER Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Spain

de la Torre A.L.:
 Microbiology Department and Pneumology Department, Hospital Universitari Germans Trias i Pujol, Institut d’Investigació Germans Trias i Pujol, Badalona, Spain

 Universitat Autònoma de Barcelona. CIBER Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Spain

García-Olivé I.:
 Microbiology Department and Pneumology Department, Hospital Universitari Germans Trias i Pujol, Institut d’Investigació Germans Trias i Pujol, Badalona, Spain

 Universitat Autònoma de Barcelona. CIBER Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Spain

Rello J.:
 Critical Care Department, Hospital Vall d’Hebron, Barcelona, Spain

Moyano S.:
 Critical Care Department, Hospital Vall d’Hebron, Barcelona, Spain

Sibila O.:
 Servei de Pneumologia, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain

Rodrigo-Troyano A.:
 Servei de Pneumologia, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain

Solé-Violán J.:
 Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Spain

Uranga A.:
 Pulmology Department, Hospital of Galdakao-Usansolo, Spain

van Boven J.F.M.:
 Hospital Universitari Son Espases, Palma de Mallorca, Spain

Torra E.V.:
 Intensive Care Medicine, Hospital de Mataró, Spain

Pujol J.A.:
 Intensive Care Medicine, Hospital de Mataró, Spain

Feldman C.:
 Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Yum H.K.:
 Inje Univ. Seoul Paik Hospital, South Korea

Fiogbe A.A.:
 Pulmonology and Infectious Diseases Service/University hospital of Sylvanus Olympio, Lomé, Togo

Yangui F.:
 Department of Pneumology, Hospital of Internal Forces Security (I.F.S), Marsa, Tunis, Tunisia

Bilaceroglu S.:
 Izmir Dr. Suat Seren Training and Research Hospital for Thoracic Medicine and Surgery, Izmir, Turkey

Dalar L.:
 Pulmonary Medicine, Istanbul Bilim University, Istanbul, Turkey

Yilmaz U.:
 Suat Seren Chest Disease and Surgery Training and Research Hospital, Izmir, Turkey

Bogomolov A.:
 Vinnitsa National Pirogov Memorial Medical University, Vinnitsa regional antituberculosis hospital, Vinnitsa, Ukraine

Elahi N.:
 Dubai Hospital, United Arab Emirates

Dhasmana D.J.:
 Victoria Hospital, NHS Fife, Kirkcaldy, United Kingdom

Ions R.:
 University Hospitals of Leicester NHS Trust and University of Leicester, Leicester, United Kingdom

Skeemer J.:
 University Hospitals of Leicester NHS Trust and University of Leicester, Leicester, United Kingdom

Woltmann G.:
 University Hospitals of Leicester NHS Trust and University of Leicester, Leicester, United Kingdom

Hancock C.:
 Royal Respiratory Research Team, Royal Liverpool University Hospital, Liverpool, United Kingdom

Hill A.T.:
 Royal Infirmary and University of Edinburgh, United Kingdom

Rudran B.:
 The Royal London Hospital, Barts Health Trust, London, United Kingdom

Ruiz-Buitrago S.:
 Hairmyres Hospital, Eaglesham Road, East Kilbride, G75 8RG, United Kingdom

Campbell M.:
 Hairmyres Hospital, Eaglesham Road, East Kilbride, G75 8RG, United Kingdom

Whitaker P.:
 Department of Respiratory Medicine, St James’s Hospital, Leeds, LS9 7TF, United Kingdom

Youzguin A.:
 South-port and Ormskirk Hospitals NHS Trust, United Kingdom

Singanayagam A.:
 Imperial College Healthcare NHS Trust, London, United Kingdom

Allen K.S.:
 University of Oklahoma Health Sciences Center, United States

Brito V.:
 Infectious diseases Unit and Pneumology Service, Parc Sanitari Sant Joan de Deu, Sant Boi, Barcelona, Spain

Dietz J.:
 Fargo VA Health Care System, Fargo, ND, United States

Dysart C.E.:
 Clement J. Zablocki VA Medical Center, 5000 W. National Ave, Milwaukee, WI 53295, United States

 Division of Infectious Diseases, University of New Mexico School of Medicine, Raymond G. Murphy VA Medical Center, 1501 San Pedro SE, Albuquerque, NM 87108, United States

Kellie S.M.:
 Clement J. Zablocki VA Medical Center, 5000 W. National Ave, Milwaukee, WI 53295, United States

 Division of Infectious Diseases, University of New Mexico School of Medicine, Raymond G. Murphy VA Medical Center, 1501 San Pedro SE, Albuquerque, NM 87108, United States

Franco-Sadud R.A.:
 Division of Hospital Medicine, Cook County Hospital, Chicago, United States

Meier G.:
 Division of Hospital Medicine, Cook County Hospital, Chicago, United States

Gaga M.:
 7th Resp. Med. Dept and Asthma Center, Athens Chest Hospital, United States

Holland T.L.:
 Department of Medicine, Duke University Medical Center and School of Medicine, Duke Clinical Research Institute, United States

Bergin S.P.:
 Department of Medicine, Duke University Medical Center and School of Medicine, Duke Clinical Research Institute, United States

Kheir F.:
 Department of Pulmonary Diseases, Critical Care & Environmental Medicine, Tulane University Health Sciences Center, New Orleans, LA, United States

Landmeier M.:
 Division of Pulmonary and Critical Care Medicine, Northwestern Memorial Hospital, Chicago, IL 60611, United States

Lois M.:
 John Peter Smith Hospital, Fort Worth, TX 76104, United States

Nair G.B.:
 Interstitial Lung Disease Programand Pulmonary Rehabilitation, SUNY Stony Brook Winthrop University Hospital, Mineola, NY 115501, United States

Patel H.:
 Department of Medicine, Division of General Internal Medicine, Hospital Medicine Group, University of Colorado, United States

Reyes K.:
 Henry Ford Hospital, Detroit, IL, United States

Rodriguez-Cintron W.:
 Pulmonary/Critical Care Medicine VA Caribbean Healthcare System, United States

Saito S.:
 Tulane University, New Orleans, United States

Noda J.:
 Divisions of Hospital Medicine & Pulmonary/Critical Care Medicine, South Texas Veterans Health Care System, University of Texas Health Science Center San Antonio, San Antonio, TX, United States

Hinojosa C.I.:
 Divisions of Hospital Medicine & Pulmonary/Critical Care Medicine, South Texas Veterans Health Care System, University of Texas Health Science Center San Antonio, San Antonio, TX, United States

Levine S.M.:
 Divisions of Hospital Medicine & Pulmonary/Critical Care Medicine, South Texas Veterans Health Care System, University of Texas Health Science Center San Antonio, San Antonio, TX, United States

Angel L.F.:
 Divisions of Hospital Medicine & Pulmonary/Critical Care Medicine, South Texas Veterans Health Care System, University of Texas Health Science Center San Antonio, San Antonio, TX, United States

Whitlow K.S.:
 Kaweah Delta Health Care District, Department of Emergency Medicine, Visalia, CA, United States

Hipskind J.:
 Kaweah Delta Health Care District, Department of Emergency Medicine, Visalia, CA, United States

Sukhija K.:
 Kaweah Delta Health Care District, Department of Emergency Medicine, Visalia, CA, United States

Totten V.:
 Kaweah Delta Health Care District, Department of Emergency Medicine, Visalia, CA, United States

Wunderink R.G.:
 Northwestern University Feinberg School of Medicine, Chicago, IL, United States

Shah R.D.:
 Northwestern University Feinberg School of Medicine, Chicago, IL, United States

Mateyo K.J.:
 Department of Internal Medicine, University Teaching Hospital, Lusaka, Zambia
ISSN: 01634453
Editorial
W B SAUNDERS CO LTD, 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND, Estados Unidos America
Tipo de documento: Article
Volumen: 79 Número: 4
Páginas: 300-311
WOS Id: 000486605900002
ID de PubMed: 31299410
imagen Green Accepted

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