Cardiovascular Benefits of Phenol-Enriched Virgin Olive Oils: New Insights from the Virgin Olive Oil and HDL Functionality (VOHF) Study
Por:
Pedret A., Fernández-Castillejo S., Valls R.-M., Catalán Ú., Rubió L., Romeu M., Macià A., López de las Hazas M.C., Farràs M., Giralt M., Mosele J.I., Martín-Peláez S., Remaley A.T., Covas M.-I., Fitó M., Motilva M.-J., Solà R.
Publicada:
1 ene 2018
Resumen:
Scope: The main findings of the “Virgin Olive Oil and HDL Functionality” (VOHF) study and other related studies on the effect of phenol-enriched virgin olive oil (VOO) supplementation on cardiovascular disease are integrated in the present work. Methods and results: VOHF assessed whether VOOs, enriched with their own phenolic compounds (FVOO) or with those from thyme (FVOOT), improve quantity and functionality of HDL. In this randomized, double-blind, crossover, and controlled trial, 33 hypercholesterolemic subjects received a control VOO (80 mg kg-1), FVOO (500 mg kg-1), and FVOOT (500 mg kg-1; 1:1) for 3 weeks. Both functional VOOs promoted cardioprotective changes, modulating HDL proteome, increasing fat-soluble antioxidants, improving HDL subclasses distribution, reducing the lipoprotein insulin resistance index, increasing endogenous antioxidant enzymes, protecting DNA from oxidation, ameliorating endothelial function, and increasing fecal microbial metabolic activity. Additional cardioprotective benefits were observed according to phenol source and content in the phenol-enriched VOOs. These insights support the beneficial effects of OO and PC from different sources. Conclusion: Novel therapeutic strategies should increase HDL-cholesterol levels and enhance HDL functionality. The tailoring of phenol-enriched VOOs is an interesting and useful strategy for enhancing the functional quality of HDL, and thus, it can be used as a complementary tool for the management of hypercholesterolemic individuals. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Filiaciones:
Pedret A.:
Eurecat, Centre Tecnològic de Catalunya, Unitat de Nutrició i Salut, Functional Nutrition, Oxidation, and CVD Research Group (NFOC-Salut), Reus, 43204, Spain
Facultat de Medicina i Ciències de la Salut, Functional Nutrition, Oxidation and Cardiovascular Diseases Group (NFOC-Salut), Universitat Rovira i Virgili, Reus, 43201, Spain
Fernández-Castillejo S.:
Facultat de Medicina i Ciències de la Salut, Functional Nutrition, Oxidation and Cardiovascular Diseases Group (NFOC-Salut), Universitat Rovira i Virgili, Reus, 43201, Spain
Institut d'Investigació Sanitaria Pere Virgili, Reus, 43204, Spain
Valls R.-M.:
Facultat de Medicina i Ciències de la Salut, Functional Nutrition, Oxidation and Cardiovascular Diseases Group (NFOC-Salut), Universitat Rovira i Virgili, Reus, 43201, Spain
Catalán Ú.:
Facultat de Medicina i Ciències de la Salut, Functional Nutrition, Oxidation and Cardiovascular Diseases Group (NFOC-Salut), Universitat Rovira i Virgili, Reus, 43201, Spain
Institut d'Investigació Sanitaria Pere Virgili, Reus, 43204, Spain
Rubió L.:
Facultat de Medicina i Ciències de la Salut, Functional Nutrition, Oxidation and Cardiovascular Diseases Group (NFOC-Salut), Universitat Rovira i Virgili, Reus, 43201, Spain
Antioxidants Research Group, Food Technology Department, Universitat de Lleida-Agrotecnio Center, Lleida, 25198, Spain
Romeu M.:
Facultat de Medicina i Ciències de la Salut, Functional Nutrition, Oxidation and Cardiovascular Diseases Group (NFOC-Salut), Universitat Rovira i Virgili, Reus, 43201, Spain
Macià A.:
Antioxidants Research Group, Food Technology Department, Universitat de Lleida-Agrotecnio Center, Lleida, 25198, Spain
López de las Hazas M.C.:
Antioxidants Research Group, Food Technology Department, Universitat de Lleida-Agrotecnio Center, Lleida, 25198, Spain
Laboratory of Epigenetics of Lipid Metabolism, Instituto Madrileño de Estudios Avanzados-Alimentación, CEI UAM+CSIC, Madrid, 28049, Spain
Farràs M.:
Institut d'Investigacions Biomèdiques (IIB) Sant Pau, Barcelona, 08025, Spain
Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, Hospital del Mar Research Institute (IMIM), Barcelona, 08003, Spain
Giralt M.:
Facultat de Medicina i Ciències de la Salut, Functional Nutrition, Oxidation and Cardiovascular Diseases Group (NFOC-Salut), Universitat Rovira i Virgili, Reus, 43201, Spain
Mosele J.I.:
Antioxidants Research Group, Food Technology Department, Universitat de Lleida-Agrotecnio Center, Lleida, 25198, Spain
Instituto de Bioquímica y Medicina Molecular (IBIMOL), CONICET - Universidad de Buenos Aires, Buenos Aires, 1053, Argentina
Facultad de Farmacia y Bioquímica, Departamento de Química Analítica y Fisicoquímica, Cátedra de Fisicoquímica, Universidad de Buenos Aires, Buenos Aires, C1113AAD, Argentina
Martín-Peláez S.:
Spanish Biomedical Research Networking Centre (CIBER), Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, Madrid, 28029, Spain
Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, Hospital del Mar Research Institute (IMIM), Barcelona, 08003, Spain
Remaley A.T.:
Department of Laboratory Medicine Clinical Center, National Institutes of Health, Bethesda, MD 20814, United States
Lipoprotein Metabolism Section Cardio-Pulmonary Branch National Heart, Lung and Blood Institute National Institutes of Health, Bethesda, MD 20814, United States
Covas M.-I.:
Spanish Biomedical Research Networking Centre (CIBER), Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, Madrid, 28029, Spain
Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, Hospital del Mar Research Institute (IMIM), Barcelona, 08003, Spain
NUPROAS (Nutritional Project Assessment), Handesbolag (NUPROAS HB), Nacka, 13100, Sweden
Fitó M.:
Spanish Biomedical Research Networking Centre (CIBER), Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, Madrid, 28029, Spain
Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, Hospital del Mar Research Institute (IMIM), Barcelona, 08003, Spain
Motilva M.-J.:
Antioxidants Research Group, Food Technology Department, Universitat de Lleida-Agrotecnio Center, Lleida, 25198, Spain
Solà R.:
Facultat de Medicina i Ciències de la Salut, Functional Nutrition, Oxidation and Cardiovascular Diseases Group (NFOC-Salut), Universitat Rovira i Virgili, Reus, 43201, Spain
Institut d'Investigació Sanitaria Pere Virgili, Reus, 43204, Spain
Hospital Universitari Sant Joan de Reus, Reus, 43204, Spain
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