Effectiveness of vaccination with 23-valent pneumococcal polysaccharide vaccine in preventing hospitalization with laboratory confirmed influenza during the 2009-2010 and 2010-2011 seasons
Por:
Dominguez, A, Castilla, J, Godoy, P, Delgado-Rodriguez, M, Saez, M, Soldevila, N, Astray, J, Mayoral, JM, Martin, V, Quintana, JM, Gonzalez-Candelas, F, Galan, JC, Tamames, S, Castro, A, Baricot, M, Garin, O, Pumarola, T, Bonfill X., López-Contreras J., Pomar V., Puig, MT, CIBERESP Cases Controls Pandemic
Publicada:
1 abr 2013
Resumen:
Background: Since influenza predisposes to bacterial pneumonia caused by Streptococcus pneumoniae, studies have suggested that pneumococcal vaccination might reduce its occurrence during pandemics. We assessed the effectiveness of pneumococcal polysaccharide vaccination alone and in combination with influenza vaccination in preventing influenza hospitalization during the 2009-2010 pandemic wave and 2010-2011 influenza epidemic. Methods: We conducted a multicenter case-control study in 36 Spanish hospitals. We selected patients aged 18 y hospitalized with confirmed influenza and two hospitalized controls per case, matched according to age, date of hospitalization and province of residence. Multivariate analysis was performed using conditional logistic regression. Subjects were considered vaccinated if they had received the pneumococcal or seasonal influenza vaccine > 14 d (or > 7 d for pandemic influenza vaccine) before the onset of symptoms (cases) or the onset of symptoms in matched cases (controls). Results: 1187 cases and 2328 controls were included. The adjusted estimate of effectiveness of pneumococcal vaccination in preventing influenza hospitalization was 41% (95% CI 8-62) in all patients and 43% (95% CI 2-78) in patients aged 65 y. The adjusted effectiveness of dual PPV23 and influenza vaccination was 81% (95% CI 65-90) in all patients and 76% (95% CI 46-90) in patients aged 65 y. The adjusted effectiveness of influenza vaccination alone was 58% (95% CI 38-72). Conclusions: In elderly people and adults with chronic illness, pneumococcal vaccination may reduce hospitalizations during the influenza season. In people vaccinated with both the influenza and pneumococcal vaccines, the benefit in hospitalizations avoided was greater than in those vaccinated only against influenza.
Filiaciones:
Dominguez, A:
Univ Barcelona, Dept Salut Publ, Barcelona, Spain
CIBERESP, Madrid, Spain
Castilla, J:
CIBERESP, Madrid, Spain
Inst Salud Publ Navarra, Pamplona, Spain
Godoy, P:
CIBERESP, Madrid, Spain
Generalitat Catalunya, Dept Salut, Barcelona, Spain
Delgado-Rodriguez, M:
CIBERESP, Madrid, Spain
Univ Jaen, Jaen, Spain
Saez, M:
CIBERESP, Madrid, Spain
Univ Girona, GRECS, Girona, Spain
Soldevila, N:
CIBERESP, Madrid, Spain
Astray, J:
Comunidad Madrid, Area Epidemiol, Madrid, Spain
Mayoral, JM:
Serv Vigilancia Andalucia, Seville, Spain
Martin, V:
CIBERESP, Madrid, Spain
Univ Leon, Inst Biomed, E-24071 Leon, Spain
Quintana, JM:
CIBERESP, Madrid, Spain
Hosp Galdakao Usansolo, Unidad Invest, San Sebastian, Spain
Gonzalez-Candelas, F:
CIBERESP, Madrid, Spain
Univ Valencia, Ctr Super Invest Salud Publ, Valencia, Spain
Galan, JC:
CIBERESP, Madrid, Spain
Hosp Univ Ramon y Cajal, Madrid, Spain
Tamames, S:
Junta Castilla & Leon, Direcc Gen Salud Publ & Invest, Leon, Spain
Castro, A:
CIBER Enfermedades Resp, Madrid, Spain
Baricot, M:
CIBERESP, Madrid, Spain
Garin, O:
CIBERESP, Madrid, Spain
Inst Municipal Invest Med, E-08003 Barcelona, Spain
Pumarola, T:
REIPI, Barcelona, Spain
Bonfill X.:
Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain
López-Contreras J.:
Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain
Pomar V.:
Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain
Puig, MT:
Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain
Green Published, Bronze
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