Evolving Brain Functional Abnormalities in PSEN1 Mutation Carriers: A Resting and Visual Encoding fMRI Study
Por:
Sala-Llonch, R, Fortea, J, Bartres-Faz, D, Bosch, B, Llado, A, Pena-Gomez, C, Antonell, A, Castellanos-Pinedo, F, Bargallo, N, Molinuevo, JL, Sanchez-Valle, R
Publicada:
1 ene 2013
Resumen:
PSEN1 mutations are the most frequent cause of familial Alzheimer's disease and show nearly full penetrance. Here we studied alterations in brain function in a cohort of 19 PSEN1 mutation carriers: 8 symptomatic (SMC) and 11 asymptomatic (AMC). Asymptomatic carriers were, on average, 12 years younger than the predicted age of disease onset. Thirteen healthy subjects were used as a control group (CTR). Subjects underwent a 10-min resting-state functional magnetic resonance imaging (fMRI) scan and also performed a visual encoding task. The analysis of resting-state fMRI data revealed alterations in the default mode network, with increased frontal connectivity and reduced posterior connectivity in AMC and decreased frontal and increased posterior connectivity in SMC. During task-related fMRI, SMC showed reduced activity in regions of the left occipital and left prefrontal cortices, while both AMC and SMC showed increased activity in a region within the precuneus/posterior cingulate, all as compared to CTR. Our findings suggest that fMRI can detect evolving changes in brain mechanisms in PSEN1 mutation carriers and support the use of this technique as a biomarker in Alzheimer's disease, even before the appearance of clinical symptoms.
Filiaciones:
Sala-Llonch, R:
Univ Barcelona, Dept Psychiat & Clin Psychobiol, Barcelona, Spain
IDIBAPS, Barcelona, Spain
Fortea, J:
Hosp Clin Barcelona, Dept Neurol, Alzheimers Dis & Other Cognit Disorders Unit, E-08036 Barcelona, Spain
Hosp Santa Creu & Sant Pau, Dept Neurol, Memory Unit, Barcelona, Spain
Bartres-Faz, D:
Univ Barcelona, Dept Psychiat & Clin Psychobiol, Barcelona, Spain
IDIBAPS, Barcelona, Spain
Bosch, B:
IDIBAPS, Barcelona, Spain
Hosp Clin Barcelona, Dept Neurol, Alzheimers Dis & Other Cognit Disorders Unit, E-08036 Barcelona, Spain
Llado, A:
IDIBAPS, Barcelona, Spain
Hosp Clin Barcelona, Dept Neurol, Alzheimers Dis & Other Cognit Disorders Unit, E-08036 Barcelona, Spain
Pena-Gomez, C:
Univ Barcelona, Dept Psychiat & Clin Psychobiol, Barcelona, Spain
Antonell, A:
IDIBAPS, Barcelona, Spain
Hosp Clin Barcelona, Dept Neurol, Alzheimers Dis & Other Cognit Disorders Unit, E-08036 Barcelona, Spain
Castellanos-Pinedo, F:
Hosp Virgen del Puerto, Dept Neurol, Plasencia, Spain
Bargallo, N:
IDIBAPS, Barcelona, Spain
Hosp Clin Barcelona, Dept Radiol, E-08036 Barcelona, Spain
Molinuevo, JL:
IDIBAPS, Barcelona, Spain
Hosp Clin Barcelona, Dept Neurol, Alzheimers Dis & Other Cognit Disorders Unit, E-08036 Barcelona, Spain
Sanchez-Valle, R:
IDIBAPS, Barcelona, Spain
Hosp Clin Barcelona, Dept Neurol, Alzheimers Dis & Other Cognit Disorders Unit, E-08036 Barcelona, Spain
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