Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation
Por:
Estruch, M, Sanchez-Quesada, JL, Llanos, JO, Benitez, S
Publicada:
1 ene 2013
Resumen:
Electronegative low density lipoprotein (LDL(-)) is a minor modified fraction of LDL found in blood. It comprises a heterogeneous population of LDL particles modified by various mechanisms sharing as a common feature increased electronegativity. Modification by oxidation is one of these mechanisms. LDL(-) has inflammatory properties similar to those of oxidized LDL (oxLDL), such as inflammatory cytokine release in leukocytes and endothelial cells. However, in contrast with oxLDL, LDL(-) also has some anti-inflammatory effects on cultured cells. The inflammatory and anti-inflammatory properties ascribed to LDL(-) suggest that it could have a dual biological effect.
Filiaciones:
Estruch, M:
IIB St Pau, Serv Bioquim, Barcelona 08025, Spain
Univ Autonoma Barcelona, Dept Bioquim & Biol Mol, E-08193 Barcelona, Spain
Sanchez-Quesada, JL:
IIB St Pau, Serv Bioquim, Barcelona 08025, Spain
Hosp Santa Creu & Sant Pau, Serv Bioquim, Barcelona 08026, Spain
Llanos, JO:
Univ Autonoma Barcelona, Dept Bioquim & Biol Mol, E-08193 Barcelona, Spain
Hosp Santa Creu & Sant Pau, Serv Bioquim, Barcelona 08026, Spain
Benitez, S:
IIB St Pau, Serv Bioquim, Barcelona 08025, Spain
Hosp Santa Creu & Sant Pau, Serv Bioquim, Barcelona 08026, Spain
Gold, Green Published, Green
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